Excerpts

A positive and highly significant correlation was also observed between PAPPA and both IGF1 and IGF1R expression in bulk ILC ER+ tumors ( Supplementary Figure S6C ).

The data showing a highly significant improvement of local control obtained with LRHT and RT represent facts that we must consider as the basis for the further development of oncological hyperthermia and the correction of the problems with overall survival.

Furthermore, they found that having a germline mutation was associated with a significantly increased risk of prostate cancer metastases (varying from a nonsignificant relative risk (RR) for ATM mutation (RR: 1.6 (95% CI: 0.8–2.8) to highly significant for individuals with BRCA 2 mutations (RR: 26.7 (95% CI: 18.9–36.4)).

Patients with co-morbidities were more likely to present PCI, although only the association of having a diagnosis of a lung disease (asthma, chronic obstructive pulmonary disease, chronic bronchitis, surgery for lung cancer, pulmonary emphysema, and pneumonia) was nearly significant (age- and education-adjusted OR, 95%CI: 1.87, 0.97–3.60).

Data analysis from NCI-N87 showed a slight quite significant increase of CTNNB1/β-catenin after EGF treatment that it was not abolished by the addition of trastuzumab, supporting this suggestion.

Functionally, JBS2 exerted concentration-dependent reductions in the viability of estrogen receptor (ER)-negative HER2-positive SUM-225 breast cancer cells, a DCIS-like cell model ( Figure 2 E), and it showed a trend to reduce viability in a primary culture from a DCIS patient ( Figure 2 F; p = ns).

The difference was highly significant as shown in the quantitation plot on the right.

Analysis of a sub-collective of 101 patients without neoadjuvant therapy revealed a clearly significant correlation between bone marrow CK20 positivity and overall survival, which was different compared to the analysis of the entire collective.

In the multivariate linear regression, maximum labMELD ( p = 0.037) and the labMELD at the time of transplantation ( p = 0.044) were highly significant.

This is particularly relevant as there is an increasing trend towards a neoadjuvant therapy approach in breast cancer as highlighted elsewhere in this paper.

Similarly, median PFS for the last anti-EGFR-based therapy showed a trend towards a shorter mPFS in the rechallenge patients compared to the reintroduction patients without statistical significance (3.68 vs. 7.33 months, n.s.). 4.

Introduction Thyroid cancer is the most common endocrine cancer, and its incidence has shown an increasing trend over time.

Kaplan-Meier curves showed a trend toward lower RNF5 expression in patients with poor prognosis, which, however, was not significant ( p > 0.05) ( Figure 1 d).

There was a statistical trend towards higher rates of suboptimal cytoreduction in older women, where 57% of women younger than 54 years had complete cytoreduction to no macroscopic residual disease, 33% had optimal cytoreduction to macroscopic residual disease ≤ 1 cm, and 10% had suboptimal cytoreduction with macroscopic disease > 1 cm.

The time-activity curve shows a decreasing trend with a peak at 69 h.

One study showed a trend toward better preservation of hearing after FPT, reducing the total dosage from 54 to 50.4 Gy (RBE) [ 30 ].

A positive trend seen in our TGF-β gene expression data could thus be further amplified by the genetic ablation or pharmacological inhibition of TGF-β signaling.

In the literature there is also some evidence that in order to differentiate ULMS, adenomyosis and ULM, the evaluation of the endo/myometrial junctional zone may be significant, especially the vascular pattern between these two types of tissue, as was suggested by Fascilla et al.

The number of articles about cancer biosensors and antibody mimetic molecules had an increasing trend from 2004 to 2018, recombinant antibodies from 2014 to 2017, and molecularly imprinted polymers from 2013 to 2016.

Of the five quantitative studies assessing marital status as a determinant of change in smoking behavior [ 52 , 53 , 59 , 93 , 95 ], one found a marginally significant association between marital status and changes in smoking behavior, with married participants yielding higher abstinence rates in the intervention group [ 59 ].

Of the six quantitative studies that assessed stages of change , four found a statistical significant association between a higher stage of change and favorable lifestyle changes, mostly in smoking behavior [ 53 , 55 , 58 , 76 ], and one found a borderline significant association [ 54 ].

However, although pre-existing immunity towards the HLA-A2 restricted epitope correlated with longer PFS, high pre-existing and vaccine-induced immunity towards the HLA-A2 restricted epitope showed a trend towards a shorter PFS.

However, even if our results about efficacy are significant, we acknowledge that our study displays limitations, including the small number of patients in the compared groups with 12 patients in the “matched therapy group”, and 25 in the “non-matched therapy group”, and the imbalance of characteristics between these groups with a strong trend for more patients with PC in the first one (83%) than in the second one (44%).

Although not statistically significant, our data show a positive trend with the use of the different therapeutic regimens in terms of CR increase (64.5% with GnRHa + LNG-IUD versus 80.0% with MA+LNG-IUD and 83.3% with MA + LNG-IUD + MET), and a negative trend in terms of SD evidence (25.8% with GnRHa + LNG-IUD versus 15.0% with MA + LNG-IUD and 8.3% with MA + LNG-IUD + MET).

Even if not significant ( p = 0.65), an increasing trend of CR and a diminishing trend of SD were observed according to hormonal therapy ( Table 2 ).