Excerpts

p -values between 0.05 and 0.15 were considered indicative of a statistical trend.

Furthermore, unlike targeting either KDM4A or KDM4B alone, dual targeting led to a highly significant increase in Caspase activity indicative of apoptosis in these cells ( Figure 6 B and Figure S10 ), suggesting that these two demethylase family members have distinct roles in RMS cell growth and that combined inhibition of both KDM4A and KDM4B is required in RMS to induce apoptosis and reduce the potential for resistance to KDM4 subfamily targeted therapies. 4.

SST 2 and SST 5 IRS showed a slight trend for higher values in tumors from treatment-naïve patients compared to those which underwent SRL therapy before surgery (see Table 1 ), although this difference was not statistically significant (SST 2 p = 0.21, and SST 5 p = 0.65).

combo at D24: p = 0.101 as determined with the Mann–Whitney one tail test), we showed a trend towards a potentiated effect with the murlentamab/pembrolizumab combo-therapy ( Figure 5 E).

When analyzing the proliferation rate of leukemic cells by KI67 staining, a strong trend towards a higher percentage of proliferating cells was detected in the spleen of 1MT-treated mice compared to controls ( Figure 2 D; Supplementary Figure S2C for gating strategy), which might explain the loss of treatment efficacy over time.

They showed a trend for a higher rate of HER2 expression (33%) among Black patients in contrast to White patients (13%) [ 76 ].

This represents a highly significant issue, especially given the fact that Black women experience worse outcomes compared with White women with the same disease.

The IELSG32-trial showed no beneficial effect on CR rates, progression-free and overall survival by solely adding rituximab to a high-dose methotrexate-based chemotherapy regimen, although the difference in progression-free survival showed a trend of borderline significance.

Statistical Analysis The data were evaluated using Student’s t-test and were expressed as a mean ± SD * p ≤ 0.1 significant, ** p ≤ 0.01 very significant, *** p ≤ 0.001 highly significant.

Firstly, there may be significant differences in the outcome and safety of cabozantinib in real-life use compared to trial settings.

However, even after the adjustment in the multivariable model, there was a highly significant association of four age groups with the LINE-1 methylation level ( P trend < 0.0001 across the age groups).

Even though not all differences were significant, a clear trend could be observed in all cell lines, both in percentage of dying cells, as well as dead cells due to apoptosis and necrosis ( Figure 3 C,D).

When comparing the adverse events, we identified a clear trend toward higher postoperative complication rates—especially for reoperation, prolonged hospital admission and delay of adjuvant RT—in patients that suffered HAIs (OR 17.34, 95% CI 2.09–143.28; p < 0.001).

In multivariate analysis, the occurrence of toxicities was associated with OS, but BMI was at the limit of significance.

It is noteworthy that in our gene expression analyses, PDL1 reached a statistical trend, suggesting the potential existence of a biological interrelationship between the two immune checkpoints.

In this study, the incidence of cholangiocarcinoma is significantly increased by 77% in DPP-4 inhibitor users (HR 1.77, 95%CI: 1.04–3.01), and an increasing trend in GLP-1 receptor agonist (GLP-1RA) users as well (HR 1.97, 95%CI: 0.83–4.66).

Kaplan–Meier PFS and overall survival (OS) curves showed a trend between the values of ratio (cut-off: −0.05) and the duration of response: patients with a low ratio (<−0.05) had lower PFS and OS compared with patients with a higher ratio (≥−0.05) ( p = 0.022 and p = 0.016, respectively) ( Figure 4 ). 4.

[ 28 ] found no significant association between obesity and ICB outcomes in RCC but these authors did identify a strong trend toward beneficial effects of obesity.

However, among men, there was a significant trend towards higher BCC risk with longer duration of statin use (P-trend = 0.003). 3.5.2.

The heritability of LINE-1 methylation may be gender-specific and there was a marginally significant inverse association between LINE-1 hypomethylation levels and increased TGCT risk [ 76 ].

Generally, all piRNAs selected for validation showed a trend of decreased quantities in TGCT patients, which was also observed in the sequencing cohort. 4.

This was, however, only marginally significant and lacks justification why should minimally invasive surgery be a risk factor for LLL development.

Korean females have shown a decreasing trend of age at menarche and an increasing trend of height [ 74 , 75 , 76 , 77 ].

However, both the global incidence and mortality of CRC are expected to increase by 2030 due to an increasing trend in the CRC burden in many other countries [ 2 ].

pinnatifida , showed a significant trend toward an inverse association with the risk of overall CRC (odds ratio (OR), 95% confidence interval (CI) = 0.2 [0.0–0.9], P trend < 0.01) and rectal cancer (OR, 95% CI = 0.4 [0.1–1.1], P trend = 0.01) as a case-control study in Japan [ 184 ].