Excerpts

These findings suggest that independent of socioeconomic or environmental factors, there may be significant variations in the underlying tumor biology and differential mechanisms by which endometrial cancer propagates.

All methods revealed a definite trend to rising CTC counts with advancing tumour burden.

Regarding 12-months OS rate, the RIT group shows a clear trend for a better OS.

Significant inverse association was observed between total plasma carotenoid concentrations and oxidative stress measured by urinary 8-hydroxy-2’-deoxyguanosine (8-OHdG) while only modest significance was shown for 8-iso-prostaglandin F2α (8-iso-PGF2α).

Treatment with mevalonate alone showed a trend toward further tumor growth relative to the control group; the addition of mevalonate to metformin treatment induced a significant increase in tumor growth compared to metformin treatment alone, indicating that mevalonate could reverse the tumor-suppressing effect of metformin ( Figure 4 B–D).

From our data, BRAF mutation showed a trend towards poor DFS, despite not statistically significant ( Table 2 ).

Therefore, irAEs can be therapeutically detrimental with an increasing trend of combo therapies, considering that the related toxicity needs to be controlled without impairing the ideal anti-tumor effect of ICIs.

Similarly, VEGF-A expression in the MM cells showed an increasing trend.

Low-density lipoprotein (LDL) cholesterol showed a trend to increase, but we did not observe any significant change either after 6 months (135 mg/dL (65–205) at baseline vs. 157 uUI/mL (85−293) at 6 months, p = 0.13), or during the whole observation period ( Figure 5 ).

The CNA burden of single CTCs of TNBC ( n = 26) and non-TNBC ( n = 23) patients did not differ significantly ( p = 0.18), although the violin plots showed a trend of heterogeneity in terms of the CNA burden ( Figure 1 ).

Compared to S-GCTs, bifocal tumors were almost exclusively male, exhibited higher rate of metastasis, and had worse rates of progression free and overall survival trending toward significance.

Tumors formed by Mgrn1 -KO B16-F10 cells had lower mitotic indices, fewer Ki67-positive cells and showed a trend towards smaller size.

The effect of the genotype was highly significant for patients with pleural mesothelioma but not for patients with peritoneal mesothelioma and remained significant after adjusting for gender and age at diagnosis.

In this case, we observed a highly significant increase in the number of TNTs (as illustrated in Figure 3 a–d and summarized in Figure 3 e).

Ki-67 staining showed a trend towards reduced cell proliferation in the high BCL-2 expressing CRC0076 PDXs upon ABT-199 treatment.

Our data suggest a numerical trend towards decreased cell proliferation (Ki-67 staining) in CRC0076 (which expresses high levels of BCL-2) following ABT-199 treatment ( Figure S5 ). 2.3.

Further studies highlighted the significant association of hMSH3 mutations with the development of leukoplakia and its progression to OSCC and that a decreasing trend in MMR expression can be detected when testing non-dysplastic samples and oral preneoplastic lesions with progressively increasing severity [ 61 , 65 ].

A trend toward significance was found between high GII and CTH, an association already reported [ 49 , 52 ].

However, recent meta-analyses demonstrated a nonsignificant trend in overweight and obese children [ 58 , 63 ] ( Table 3 ).

Apart from BxPC-3 cells, tested PDAC cell lines demonstrated either a significantly higher sensitivity to protons than photons or showed a trend towards higher sensitivity to protons that resulted in reduced tumoroid growth ( Figure 1 D).

All other endpoints had a positive trend towards favoring the experimental arm, though no statistically significant differences were observed, except for the OR rate which was superior in the experimental arm, due to a proportionally larger number of patients with CR.

PFS HR for arm B was 0.65 (95% CI: 0.41–1.03), therefore not significantly worse than arm A and with a strong trend to superiority towards arm A.

In the crude model, we observed a statistically significant or marginally significant trend in all sites of cancer.

Univariate analysis showed no differences according to gender, blood pressure status or vigorous physical activity, but subjects with tobacco use ( p = 0.076) and obesity ( p = 0.058) showed a trend to develop RCys.

We also observed a nearly significant enrichment of KRAS mutation in patients harboring at least one mucin gene alteration.