These findings were further validated across multiple independent cohorts: the Lauss 2017 CAR-T therapy cohort showed a trend toward improved PFS (P = 0.064), while the Cho 2020 (anti-PD-1/PD-L1, PFS, P = 0.021), IMvigor210 2018 (anti-PD-L1, OS, P = 0.0051), and Nathanson 2017 (anti-CTLA-4, OS, P = 0.04) cohorts consistently confirmed that high SLFN11 expression is associated with favorable prognosis in immunotherapy settings ( Figure 4B ).
In EOMG, T-bet expression in CD11c + B cells showed a positive trend with disease duration (r = 0.54, p = 0.064), suggesting that T-bet expression may gradually increase as disease progresses ( Figure 7B ).
rhamnosus GG combined with SCF intervention almost reached significance for the E / T of 100 ( p = 0.064) compared to baseline in females but not in males (Figure 4 B).
With the use of median value as cutoff, patients with kyn/trp ratio > 0.06 had a higher risk to develop an early progression (within 3 months) to nivolumab with a trend toward significance ( p = 0.064 at multivariate analysis).
These time-dependent increases were significant for End1 (p=0.0277) and Vk2 (p=0.0044) and showed a trend for Ect1 (p=0.0642).
The CD4+ T h cells had a decreasing trend in the GK rats (~2.5-fold), compared to Wistar rats (p=0.0649, Mann-Whitney test, Figure 1C ).
VDR and RANK statistically significantly differed between the two groups in terms of the intensity scores ( p -value <0.05), and VDR showed a trend-level difference in terms of the extent scores ( p -value = 0.065) ( Tables 5 , 6 ).
When we compared the relative abundances of bacteria at genera level, we found that Mycoplasma (from Mollicutes class) displayed the principal shift, although slightly non-significant ( P = 0.065).
The difference in the ratio of ERα: ERβ mRNA between the control and SLE T cell samples approached significance ( p = 0.065), even though the ratio was less than unity for all samples in both groups.
For the composite endpoint of MACE ( Figure 3D ), C5-treated patients exhibited lower event-free survival (91.4% vs 93.7%), with a trend toward significance (p=0.065), although the HR did not reach statistical significance (HR 1.355; p=0.181).
Impact of type of organ-specific irAEs on survival Cutaneous irAEs were associated with a favorable trend toward improved PFS and OS (p=0.065), especially in the higher-line group.
Although the HAIT-M-P group showed a trend toward better OS than the HAIT group, the difference did not reach statistical significance (HR = 0.45, 95% CI: 0.19 – 1.07, P = 0.065; Figure 2D ).
Patients with disease activity higher than the median at golimumab initiation showed a trend to lower retention (p=0.066).
Additionally, patients with an increased FoxP3/CD8 cell density ratio demonstrated a strong trend towards decreased 10-year OS (p = 0.066).
In the gray matter, TNFα was elevated in VS PWH (p<0.05), and an increasing trend was present in nVS PWH (p=0.066; Figure 2F ), indicating widespread production of TNFα within the frontal cortex of the brain from PWH.
Monocytes also showed a trend toward a sex effect (p = 0.0666), with females tending to exhibit higher counts than males at 24 hpi (p = 0.1346) ( Supplementary Figure 4E ).
Moreover, the increase of T cell inflamed score upon EGFR-TKI treatment and longer TTP exhibited a correlation with a trend toward significance ( p = 0.067 , Figure 1F ).
This contribution was significant for S2 ( p = 0.013) and almost significant for RBD ( p = 0.067) and S1S2 ( p = 0.052).
IL-1β levels showed a trend for correlation with MOM feed (p-value=0.067) ( Figure 3C ), while it did not associate with GA ( Figure 3D ).
Intermediate monocytes showed a trend toward a positive association with the maximum ILT thickness (r P = 0.32, p = 0.067) ( Figure 3D ).
Using a cell-based assay we depicted a reduced neutralization capacity in the Ofa group compared to HC against wild type (WT, p=0.0220), Delta with borderline significance (p=0.0677) and Omicron (p=0.0208) variants ( Figures 3A–C ).
However, Neflamapimod treatment led to significantly reduced cerebrospinal fluid (CSF) levels compared to placebo, particularly in T-tau [difference (95% CI): -18.8 (-35.8, -1.8); P=0.031] and p-tau181 [-2.0 (-3.6, -0.5); P=0.012], with a suggestive trend for neurogranin [-21.0 (-43.6, 1.6); P=0.068].
Although lower HLA-F expression showed a trend toward better OS, this did not reach statistical significance ( p = 0.068) ( Figure 7F ).
Regarding immune cells, the density of CD8 + T cells tended to be lower cancer tissues than in paracancerous tissues, with borderline significance ( Figure 2E , P = 0.069).
Number and relative proportion of leukocyte subsets Mixed linear model analysis revealed no effect of treatment (P > 0.05) on either the absolute numbers ( Table 1 ) or the relative proportions ( Supplementary Table 2 ) of leukocyte subsets in the blood of 35-day-old broiler chickens treated in ovo with MI on ED 17, except a statistical trend in the number of CD4 + cells (P = 0.069).