Excerpts

A sex difference was apparent whereby post booster antibody levels in the adult males did not reach the levels found after the primary immunization course.

Unfortunately, instead of being concerned with complete systems, there is today a clear trend toward studies of SLE by individual disciplines unlinked from each other.

P < 0.05 was considered significant, and a P < 0.01 was considered highly significant.

Under these conditions, illumination periods of 5 min and more resulted in a strong and highly significant increase in CD8+ T cell activation, which again decreased with illumination times of more than 12 min.

Analysis of CD4 + and CD8 + T-cell populations in the spleen as a comparison showed a trend toward lower levels of CD8 + T cells in young females that reached significance in the middle age (Figure S4A in Supplementary Material).

We observed an interesting trend that the frequency of antigen-specific binding increased with up to 3 mutations in the VH region but did not increase from 3 to 10 average mutations.

In addition, NOD mice treated with CYP alone showed a trend towards reduction of T cells and effector memory T cells (not statistically significant; Figures 1 C,D).

Patients receiving a kidney with at least one G allele for the CD46 promoter polymorphism rs2796267 (A/G) showed a lower rejection-free survival, though this became borderline significant after adjustment for potential confounders (aHR 1.87, 95% CI 0.96–3.65).

However, CD2 co-stimulation could increase CD16-triggered responses also in the NKG2C − CD57 + subset (both FcεRγ + and FcεRγ neg ) although a modest significance was reached only in NKG2C − CD57 + FcεRγ pos cells (Figure 6 C), although CD2 expression levels were lower than those found in NKG2C + NK cells (Figure 4 ; Figure S4B in Supplementary Material).

Flow cytometry analysis of mice splenocytes revealed a highly significant decrease in the percentage of CD4 + Foxp3 + Tregs from 59.6 to 1.39% following C36L1 treatment (Figure S6B in Supplementary Material).

The score obtained for this prediction is highly significant (TM-score = 0.98), indicating the robustness of the prediction, as well as a structural alignment conservation with the AgTEP1 reference despite a low similarity at the amino-acid level (29%) (Figure 1 B).

The cells treated with inactivated BE, which contained inactivated JEV particles, showed a trend similar to that observed with infected BE treatment.

When we stratified the mice according to the S100a4 concentration in the BAL fluid (S100a4low versus S100a4high), the difference between the vehicle-treated mice and the niclosamide-treated, S100a4low mice became highly significant (Figure 7 C).

There is a clear trend for searches in English websites which give a lower visibility to vaccine-negative webpages.

Characteristics that were significant or nearly significant in univariable models, were considered for final multivariable models found with a backward stepwise selection approach with models comparison using likelihood-ratio tests and p > 0.10 as covariate exclusion criterion.

Moreover, BRCA1 rs12516 CC genotype had a significantly higher BRCA1 protein expression, compared to CT/TT variant genotypes and RAD51 rs7180135 AA genotype had a borderline significant association to a higher expression of RAD51 protein, compared to RAD51 rs7180135 AG/GG variant genotypes.

The reduction in the length distribution width is highly significant.

Stimulating B cells with R848 (TLR7/8 agonist) and IFNα showed a trend toward an increase in the percentage of CD19 + CD24 hi CD38 hi cells from CHC, but not in active on-treatment JDM patients [with PGA > 3.5 (range 0–10)] (Figures S5A,B in Supplementary Material).

This information is highly significant, because representative viruses from these lineages demonstrate differential neuroinvasive and inflammatory capabilities, as well as different infection profiles.

However, this effect was only marginally significant and requires further investigation.

Figure 4 shows that within 10 min of CD31 ligation, there were highly significant phosphorylations of ZAP70, Akt, RelA, and cAbl compared to the IgG istotype controls in synovial DN and CD8 + αβT cells.

We observed that slow-growing tumors induced by a low dose of MCA (5 μg) expressed high levels of cell surface NKG2D ligand and showed a trend to develop earlier in NKG2D-sufficient than NKG2D-deficient mice ( 35 ).

The injection of 375 pmol [3-NT 61 ]CXCL12 showed a trend of reduced lymphocyte extravasation (median number of 1.4 × 10 3 cells) compared to CXCL12.

This is corroborated by a positive trend between the frequency of circulating T FR and neutralization breadth in HIV infected children and negative trend in the same group between PD1 expression and breadth (Figures S3F,G).

In conclusion, a substantial and statistically highly significant reduction of C5a receptors was observed in NSTEMI patients treated with tocilizumab, and as for C5aR1, the downregulation correlated with attenuated TnT release.