Excerpts

Logistic regression analysis revealed that there was no significant correlation between HCC metastasis risk and the age of genotype or allele frequency for rs17501292 (T/G), while gender showed a borderline significant effect on HCC metastasis risk, with a p -value of 0.045 ( Table 6 A).

27% on placebo; remission (MADRS ≤ 10) showed a trend (36% vs. 7%).

In linear proteomic analyses, STAT3 showed a trend towards increased expression in COPD, consistent with the sustained activation of the JAK/STAT axis reported in chronic pulmonary diseases [ 11 , 21 ].

Although the hazard ratios (HRs) for all microRNAs were greater than 1—suggesting a possible trend toward increased mortality risk with higher expression levels—their confidence intervals included 1, confirming the absence of statistical significance ( Table 5 ).

Meanwhile, the erythema index decreased in the test group, whereas an increasing trend was observed in the control group ( Figure 12 C, Table 2 ).

Serum P2X7R levels showed a trend toward elevation in both male and female mice following CIE exposure, reflecting the ethanol-induced upregulation of P2X7R observed in microglia in prior studies [ 79 , 80 ].

After acute hypoxia exposure, the myocardial apoptosis rate in the H + Con group reached 8.39 ± 0.10% ( p < 0.01), showing a highly significant increase, whereas the myocardial apoptosis rate in the H + CIF group increased to 1.17 ± 0.15% and was significantly lower than that in the H + Con group ( p < 0.01, Figure 2 B).

The results showed that the left ventricular ejection fraction (LVEF) and left ventricular shortening fraction (LVSF) of rats significantly decreased after acute hypoxia ( p < 0.01), and the heart rate showed an increasing trend.

The ROS level in the H + CIF group showed no significant difference compared with the N + Con and H + Con groups, but a decreasing trend was observed relative to the Con + H group ( Figure 5 C,D).

As shown in Table 3 , the overall physicochemical properties of the prepared LNPs did not exhibit a clear trend across the tested flow rates.

From an overall trend perspective, the majority of components in the PEG 0.5% formulation LNPs are distributed in the upper layer of the gradient column.

Most particles exhibit diameters exceeding 200 nm, with a decreasing trend in zeta potential and poor stability.

For enhanced interpretability of the most highly significant regions, the unadjusted p -values are also displayed on a negative logarithmic scale (−log 10 ( p )).

The feed intake showed an increasing trend with higher levels of egg yolk powder/anti-cFel d 1 IgY in the diet, although no statistically significant differences were observed.

Although the hematocrit (HCT) showed a decreasing trend, this was not statistically significant.

Injured males exhibited an increased integrated density of PSD95 fluorescence compared to sham males ( p = 0.0501), whereas females showed a trend toward reduced PSD95 expression that did not reach significance.

Within the CA1 subregion, GluN2A/PSD95 colocalization showed effects of injury ( p = 0.0575) and sex ( p = 0.0502), which approached significance, indicating a potential injury-driven decrease in colocalization in both sexes following injury.

S101 showed highly significant associations with both GNA and PRO in the F 2 population, consistent with results from the natural population.

A clear trend emerged from these results: ICCB-53 consistently showed the most favorable energy interactions across both inhibition mechanisms, suggesting a strong and stable binding affinity.

In univariate analysis, the risk of the composite endpoint was significantly higher in Qt-1 ( p = 0.030) and in Qt-5 ( p = 0.043) as compared to the Qt-3 reference, whereas both Qt-2 ( p = 0.055) and Qt-4 ( p = 0.071) demonstrated a borderline significant increase.

Notably, the expression levels of high-risk genes, including DLG5, SLC44A4 and HOXA10, show a decreasing trend across PCa EC3, PCa EC2 and PCa EC1 ( Figure S24C ).

This latter effect might be significant for ICM as PD-L1 expression increases in ICM progression to higher grades [ 28 ].

This analysis demonstrated a highly significant effect of biological condition.

The SKR treatment group exhibited a clear trend of reversion towards the normal group, indicating that the SKR significantly ameliorates the systemic metabolic disturbances induced by DKD ( Figure 4 A–D).

After waterlogging, root pyruvate content showed a decreasing trend in ‘Hongyang’, whereas it remained relatively stable in ‘Shuixiu’ throughout the treatment and was higher than in ‘Hongyang’ at all post-waterlogging time points ( Figure 4 D).