Excerpts

The Gehan–Breslow–Wilcoxon test was highly significant ( p = 0.0065), indicating that survival differences were largely driven by early events.

AB1 Reduced the Gene Expressions of BRCA1 , BRCA2 , and p53 in MCF10A Cells AB1 resulted in a highly significant reduction in the gene expression levels of BRCA1 (0.25/ p = 0.0069) by 75%, BRCA2 (0.061/ p = 0.0016) by 99.939%, and p53 (0.055/ p = 0.0019) by 99.945% compared to the control of each gene as represented in Figure 9 A. 2.6.2.

In contrast, a highly significant decrease in volumes was observed in cohort B (before vs. after AcPSMA RLT): the mean Volume-SG was 50 ± 13 mL vs. 40 ± 11 mL ( p = 0.007, Figure 1 B).

There was a significant trend in the association between the A allele of rs10838524 and rapid cycling ( p = 0.0076) and this allele increased the risk for rapid cycling both in a homozygote and a heterozygote form (that is dominant model) compared to controls.

By contrast, HPV infection resulted in a highly significant suppression ( p = 0.0076) of MMP-3 expression on intratumoral TILs (median IRS of 1.5 vs. 3.0), while the expression on peritumoral TILs remained unchanged.

+ Vitamin D Tier (Full VDIBS): AUC 0.78 (95% CI 0.73–0.81) ○ Incremental benefit: ΔAUC = +0.05 (95% CI +0.02 to +0.08, p = 0.004); ○ Likelihood ratio test: χ 2 (1 df) = 8.4, p = 0.004 (highly significant); ○ Net Reclassification Improvement: NRI = 0.12 ( p = 0.008); ○ Integrated Discrimination Improvement: IDI = 4.2% ( p = 0.012).

Regarding non-conjugated steroids, a highly significant trend towards lower values was observed (3/29/17, p = 0.008).

Peak SpO 2 fell within normal values for all groups, although a significant trend in progressive reduction was found between groups (97.7 ± 1.1% vs 97.6 ± 1.2% vs 96.8 ± 1.7% among ND, ERA and LSRA patients, respectively; p = 0.008).

Interestingly, the correlation was highly significant in LN-positive patients ( n = 1133, p = 0.008), and stronger than in LN-negative patients ( n = 2020, p = 0.041).

Relative to treatment with 130 Hz, these reductions translate to a further reduction in U87 (15% and 20%, respectively, however did not achieve significance) and KNS42 (19%, p = 0.0081 and 32%, p ≤ 0.0001) ( Figure 2 B).

In fact, between 8–30 weeks, the curve of the body-weight kinetics of aP2-ALOX15 mice was consistently below the curve of the wildtype controls, and this difference was statistically highly significant (Wilcoxon test, p < 0.0085).

However, TUBB qPCR results cannot be confirmed by RNAseq results, but TUBB is in RNAseq nominally significant between 1P and 31P ( p = 0.009).

However, the associations of these molar ratios with EDSS in patients showed a trend towards negative correlations (0/16/7, p = 0.009), and these associations with T25FWT showed a borderline tendency towards negative correlations as well (1/16/6, p = 0.061).

On the other hand, RSV induced a highly significant rise of TP53 gene expression in FaDu cells, compared to normal HaCaT cells ( p < 0.009, **) and PE/CA-PJ49 tumor cells ( p < 0.05, *) ( Figure 2 A, Table 3 ).

Effects of Curcumin on aCSK A highly significant decrease in SMA expression was seen when comparing curcumin 20 μM and 50 μM + TGF-β1 to control + TGF-β1 ( p = 0.009 and p = 0.002, Table 1 , Figure 3 ).

K + -Selective MGCs Among the two-pore domain K + channels, Traak (K2P4.1) displayed a highly significant change, increasing by 239.5% ( p = 0.0092).

The difference in Delta Ct (Ct GOI -Ct REF , in which Ct is cycle threshold, GOI is gene of interest, REF is reference gene) median values between PRODH protein-positive and PRODH-negative cases was highly significant ( p -value = 0.0099, ANOVA test), suggesting concordance between protein and transcript levels ( Figure 1 B).

As shown in Figure 4 C, a significant decrease of NRF2 transcript was detected in UV-exposed FBs, while an increase was found in UV/NGF-exposed FBs at 1 ng/mL NGF and 10 ng/mL NGF ( p < 0.05), highly significant at 100 ng/mL NGF ( p < 0.01).

Statistical differences among the data were evaluated with one-way analysis of variance (ANOVA) and Duncan’s multiple range tests, both at a significance level of p < 0.05 and at an extremely significant level of p < 0.01.

P -values of p < 0.0001 and p < 0.001 were considered extremely significant (**** or ***), p < 0.01 very significant (**) and p < 0.05 significant (*).

Significant differences in statistic were accepted if p < 0.05, and highly significant differences in statistic were accepted if p < 0.01.

Most of the models were highly significant ( p ≤ 0.01), except for the models of OH· (Y 6 ) and cell viability (Y 7 ), which were significant with a confidence interval of 95% ( p ≤ 0.05).

This deviation was highly significant ( p < 0.01) after 10 days ( Figure 6 B).

Significant differences were deemed significant, if p -values were below 0.05 ( p ≤ 0.05), and highly significant, if p -values were below 0.01 ( p ≤ 0.01) or 0.001 ( p ≤ 0.001). 5.

Notably, lenti-CRISPRi knockdown of Hb-α led to a robust increase in HIF-1α expression in the CA1 and CA3 regions at 7 days after GCI, which was highly significant as compared to the GCI control and GCI + CRISPRi-scramble control ( p < 0.01).