Barely Significant

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In addition, the compounds 3a , b , 5a , 7a , b , 9b , 11a , and 12a had slightly significant effects with IC 50 values ranging from 14.1 to 38.5 μg, the compound 3a indicated a slightly noticeable effect on HePG2 cells with IC 50 of 6.1 μg, and the compound 12a had weak toxicity on HCT 116 cells with IC 50 of 46.1 μg.
Moreover, there is a clear trend in the spectra, as revealed through their simulations ( Figure 2 ) of an increasing fraction (~55%) of a CAT1 species experiencing a more hydrophobic environment in the buffer, which leads to a decrease in δA iso of about 1 MHz, and slowed dynamics confirmed by a considerable increase of the τ c .