Barely Significant

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highly significantqualifiedgold
One immediate and highly significant implication of this finding is that it would be advisable to migrate the CO 2 C(CH 3 ) 3 group in the first rearrangement, followed by either CO 2 CH 3 or CO 2 C 2 H 5 in the second rearrangement, if it is desired to prepare an N -methyl or N -ethyl saccharin corresponding to 18 , Scheme 5 .