Excerpts

In total, 726 unique lnc-eGenes whose eQTLs in liver are colocalized with at least one nominally significant GWAS SNPs (single nucleotide polymorphisms) were identified (Supplementary Data 1 ), suggesting their expression in liver are potentially associated with cardiometabolic traits.

However, when assessing neuronal activation in the granule cell layer of the DG during memory retrieval we found that 4D-treated mice displayed a clear trend of decreased density of c-Fos+ cells relative to controls (4D vs.

Although the first experiments 33 were showing a positive trend in the near infrared, at longer wavelengths the THz efficiency was dropping again.

Further, 85 out of the 88 variants ( P < 1 × 10 −16 ) had effect size in the same direction in the two cohorts and 44 were at least nominally significant in Iceland showing good replication of effects (Supplementary Data 1 ).

Despite marginally significant interactions between ESJ and video type on levator activation and self-reported affect in Study 3, these trends were not replicated in Studies 4 or 5.

coli , active intrinsic termination sites confirmed by Rend-seq data 39 were (in ~20% of cases) accompanied by highly significant levels (>12 standard deviations above the mean; see the “Methods” section) of a nearby (within 500 bp) RNA 5′ end mapping to the opposite strand, indicative of antisense initiation (Fig. 5b–d ).

The Alzheimer’s disease PRS as originally reported lacked the highly significant APOE locus; accordingly this locus was manually added to the PRS using the tag SNP rs10414043, and an estimated β = 1.34 (ref. 62 ). rs10414043 was used in preference to the more conventional rs429358 as the latter was not robustly genotyped on all platforms.

The population fractions of the other states fluctuate over time but do not show a clear trend.

Temporal peak/gene analyses After selecting genomic features with a significant trend, we used their estimated parameters to fit the original data to reduce noise and facilitate the discovery of common trend patterns across multiple features.

With this stringent filter based on minimum absolute number of sampled species and consistently high global taxonomic coverage, the correlations between genetic and species diversity increase and the significance of the main parameters remains nearly significant (Supplementary Table 7 ).

The global PIF quartet-regulated genes showed a highly significant overlap with either of the epidermal PIF4- or vascular PIF4-regulated genes (Supplementary Data 1 ).

The corresponding I d output characteristics also shows an increasing trend with the decreasing of scan speed, and reaches a saturated value of 272 μA when the scan speed is less than 4 μm s −1 (Supplementary Fig. 5d–e ).

Nevertheless, the restricted effect size on HF did remain similar to our unrestricted analysis and the association remained nominally significant.

Such magnetic field and gate modulation of superconducting Fermi arcs open up a new avenue for the manipulation of Majorana fermions, which might be significant to the topological quantum computation.

Although valine was not significantly associated ( P REG = 0.78) with CSF Aβ 1–42 pathology in males, in females, it showed a nominally significant negative association with an estimated heterogeneity of I 2 = 49.3%.

We found that the vocal folds remained the most enriched body part (1.76×, FDR = 0.032), the larynx was marginally significant (1.53×, FDR = 0.0502), and the facial region was significantly enriched too (e.g., cheek and chin ranked 2nd, 3rd within significantly enriched body parts, 1.66× and 1.63×, FDR = 0.031 and FDR = 0.013, respectively, Supplementary Data 4 ).

Much more surprising was the highly significant, approximately 2-fold increase in fully saturated lipids resulting from PUFA supplementation (Fig. 2a ), due to the significantly increased abundance of phospholipid-incorporated saturated fatty acids (Fig. 2a , inset).

Furthermore, we could observe a highly significant positive correlation between the peak serum type I IFN levels elicited by different viral infections and the frequencies of Vβ5 + iTreg cells (Fig. 1g and Supplementary Fig. 2d ).

An increasing trend in air-sea heat flux (Fig. 4a ), which is mostly driven by a reduction in latent heat fluxes, acts to warm the SST.

When P < 0.001, the statistics were considered extremely significant (***).

The pairwise correlations between allele effect size estimates in the different cohorts were all highly significant, ranging from 0.44 between QIMR and UKBR and 0.91 between UKB and SUNLIGHT.

GWAS analysis of regulatory or functional information enrichment with LD correction (GARFIELD) revealed highly significant 3 to 4-fold enrichment of asthma-associated variants colocalizing to DNase I hypersensitive sites in several tissues with biological relevance to asthma, such as epithelium, lung, and thymus (Fig. 4a ; Supplementary Data 10 ).

In TCGA, all the top 10 deleted genes displayed significantly reduced levels of expression, whereas seven out of the top ten amplified genes showed a trend of increase in expression (although not statistically significant) likely due to the small number of samples harboring gene amplifications in heterogenous pri-PCa cohort (Supplementary Fig. 11a ).

Blocking mPTP with CsA showed a trend towards decreasing the number of neurons with caspase 3/7 activation (Supplementary Fig. 8 ).

Therefore, mutations resulting in ΔΔ G (SPR) > | 0.2 kcal mol −1 | are likely to be significant.