Barely Significant

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The Development and Interaction networks encompassed broad functional categories, spreading the networks’ genes among many different categories, so that enrichment results rarely survive multiple testing correction; nominally significant functional enrichment terms are therefore included for the annotation of the Development and Interaction networks (Fig. 2 , top panel ).
In the most significant HLA-DRA-DQA1 region, conditioning on HLA-DRB1 Leu67 ( P = 1.14 × 10 −29 , OR = 1.3) and HLA-DQA1 His129 ( P = 1.56 × 10 −13 , OR = 1.19) removed the effect of DQA1*01:02 ( P = 7.04 × 10 −22 , OR = 0.75, conditional P value is 0.54), DQA1*03:01 ( P = 3.99 × 10 −10 , OR = 1.27, conditional P value is 0.36), and rs3135359 ( P = 8.82 × 10 −21 , OR = 1.21, conditional P value is 0.06); however, the effect of rs2894257 ( P = 8.16 × 10 −36 , OR = 1.36, conditional P value is 1.2 × 10 −7 ) remained moderately significant.
Linking tropical Africa cooling to El Niño onset In ATM, the equatorial Pacific wind stress and SST response is negative but hardly significant at the end of the eruption year (Fig. 5a, b yellow curve ), indicating that in isolation from the surface cooling, the direct effect of the radiative forcing on the atmosphere cannot explain the volcanically induced western Pacific initial westerly wind anomaly (Fig. 4e, f ) and the subsequent El Niño.