Excerpts

However, there is a slight trend towards higher transcript expression in baseline tissue of high histological BDI, high biochemical biliary viability livers (Fig. 5a ).

Livers with acceptable bile chemistry showed a trend towards lower levels of histological injury in all categories, although this was only significant for injury to deep PBGs ( p = 0.022, Fig. 2a ).

Consistent with the GO analysis, the differences in the expression of multiple genes in the ECM network, including collagens ( COL1A1, COL1A2, COL3A1, COL4A1 ), fibronectin ( FN1 ), Lumican ( LUM ) and Osteonectin ( SPARC ), are highly significant in vivo compared to in vitro.

The lack of a clear trend in the direction of the estimates for all elevation gradients suggests that, at a local scale, temperature variability might not be the dominant driver of species’ elevation ranges, or has different influences depending on plant community composition.

The strength and continuity in the diurnal temperature range-species’ range size relationship, with a negative trend being visible in both island and continental mountains (Fig. 3 a), suggest that short-term temperature variation plays a major role in driving the observed range-size pattern that cannot be imputed to island-specific factors (e.g. lower competition).

A heatmap analysis of the DEGs in each cell type showed a trend in which age-related shifts in the transcriptional signature were recovered back by MetR, especially in progenitors and enterocytes (Supplementary Fig. 8a, b ).

In the kidney, TMV had a clear trend of higher expression of HAS2, although it was not significant due to large variation (Supplementary Fig.

Strikingly, within these regions both Mis3 variants alone as well as LGD + Mis3 variants as a group (i.e., damaging variants) showed highly significant enrichment.

We observed only a mild trend toward reduction in the frequency of apoptosis in HSPC subsets in Tet2 -KO relative to WT mice (Supplementary Fig. 7a ).

Meta-analyses of RNA1 fragments successfully identified a number of highly significant motifs with extremely low p -values (Fig. 3c–f , Supplementary Fig. 6 ).

‘Gradually down–regulated’ means a decreasing trend in fold change from the MCI/HC comparison to the AD/HC comparison.

‘Progressively up-regulated’ means an increasing trend in fold change from the MCI/HC comparison to the AD/HC comparison.

6b ) and showed a trend of improved glucose homeostasis, though not reaching statistical significance (Supplementary Fig. 6c ).

A decreasing trend was observed from day 1 to day 4 post-adult emergence (PAE), followed by an increase until oviposition (Fig. 1a ’).

While a direct comparison between isotype and anti-IFNγ treated mice inoculated with BCG prior to viral challenge did not reach statistical significance, animals treated with anti-IFNγ showed a clear trend towards more severe disease and higher viral loads (Fig. 2F, G ).

An increasing trend of mitochondrial content in MM, EMM1, and EMM2/1 organoids (fold change of 1.73 ± 0.10, 2.60 ± 0.11, and 3.10 ± 0.18, respectively) was quantified relative to control, suggesting that developmentally maturated organoids had an increasingly higher capacity for aerobic respiration and responded positively to maturation stimuli (Fig. 4b ).

A highly significant increase of EBNA1 protein levels was observed in western blots of cells expressing catalytically active BPLF1, while hardly any change occurred in cells expressing the mutant BPLF1 C61A (Fig. 6b ).

Further investigation of these factors showed a clear trend as they all significantly reduced base substitutions (−0.4 – −0.6 fold relative to control siRNA per DSB) and deletions (−0.25 – −0.6 fold) around the break, and all have very comparable profiles (Fig. 4A, B ).

Predictably, patients who achieved a major pathological response had a strong trend toward an improved PFS compared to those who did not.

We found a nonsignificant trend toward greater frequency of PD1 + T cells at 3 months post-resection in patients who did not have an MPR but remained disease-free at the conclusion of the trial (Supplementary Fig.

Serum ALT, AST, and ALP levels, as well as TC, TG, and NEFA levels, showed a trend to increase in HFD-fed Bach1 LTG mice compared to HFD-fed N TG mice (Supplementary Fig. 5d – i ).

Comparison of individual ligands reveals that a subset of interactions is only active in earlier time points and a decreasing trend of communication strength over time, indicating diminishing, but not complete termination of, inflammatory response (Supplementary Fig. 5f ).

In addition, the mitochondrial compartment length showed a decreasing trend when comparing the 5- and 60-min postphotoactivation periods in VAP KD but not in SNCA and SRGAP2 KD (Supplementary Fig. 4a, b ).

This information may be highly significant for the future design of more effective tumor-targeting NPs.

The bottom line of all these numerical findings is that the same system exhibits a quite significant response to the periodic driving away from thermal equilibrium, but hardly shows any reaction to the same driving as the unperturbed system approaches thermal equilibrium, or if it already started out near thermal equilibrium (stalled response).