Excerpts

On the other hand, the fact that 2961 out of 916,360 PCCRs were supported by RIC-seq is highly significant compared to the expected intersection of 381 structures for two interval sets of the same size obtained by random shifts.

In addition, by plotting the fitted κ 0 /2 π as a function of the resonance wavelength measured from 1260 nm to 1630 nm, a weak trend showing a larger κ 0 /2 π at a shorter wavelength is observed (see Supplementary Information ).

In the ALL-SIL cell line, P-S6 regulation did not show a clear trend within the first 72 h.

First, consistent with previous work 13 , lymph-node metastasis, as well as the related N-stage, had a highly significant association with pEMT in the malignant-basal subtype of HNSCC.

Moreover, higher hRNase 1 expression significantly correlated with poorer survival in tumors with grade 2 in a near-significant trend (Fig. 1b ), and hRNase 1 appeared to be a more significant poor prognostic factor in breast cancer patients with lymph node (LN)-negative non-metastasis, compared with those with LN-positive metastasis (Fig. 1c ).

For the 61,575 genes that had representative sequences in UniRef, were FDR-significant, were robust, and were associated with IBD, 2104 (3.4%) were nominally significant in the validation cohort.

SPARC models thus predict a decreasing trend in ODS lifetimes, reflecting the disequilibrium between tropospheric and stratospheric concentrations when tropospheric concentrations are increasing.

During that time, global river discharges showed a trend of decreasing N:P due to human activities and P was considered the primary limiting nutrient in surface waters 95 .

However, the 95th percentiles of the distributions peak at 15 species for butyrate and 12 species for total biomass and display a decreasing trend with richness beyond these thresholds.

The parameter δ i ,DJO ( t ) yields the following main specification based on a (almost insignificant) general effect, and a strong negative effect of about additional 1.655 percentage point reductions in growth for poor countries (i.e., having GDP per-capita [PPP] below the median in the base year): 22 δ i , DJO ( t ) = 0.00261 ⋅ T i ( t ) − T i 0 − 0.01655 ⋅ T i ( t ) − T i 0 1 GDP CAP , i ( t 0 ) < M e d i a n ( GDP CAP , i ( t 0 ) ) Kahn et al.

Individual genetic correlations were nominally significant at α = 0.05 (based on | r G |> 1.96SE) except those between body and abdomen mass and between body mass and female LRS.

While we did not find a clear trend in the association between educational level and risk of infection as reported in other countries 29 – 31 , we found that those with a doctorate degree were at highest risk, reflecting our previous findings in the Geneva population 21 ; this risk is likely linked to the type of occupations held by these individuals, most of whom worked in the healthcare sector in our sample.

Accordingly, our BA signature also correlated with the shorter survival of relapsing patients and showed a trend towards an increased frequency of peritoneal disease upon relapse (Fig. 3f , Supplementary Fig. 3d ), consistent with the pattern of metastatic spread in patients with rCRCs 12 , 13 .

In addition, animals in the 3M-052-Alum group showed a trend towards lower lung pathology compared to animals in the Alum alone group.

The phosphoproteomes of fresh-frozen and formalin-fixed cells also showed a good correlation with Pearson correlation coefficients of 0.7–0.9 ( p < 0.01), an expected trend, considering that the variability is generally higher on the (phospho-)peptide level (Supplementary Fig. 5B ).

In addition, recent studies have suggested that the strength of the terrestrial carbon sink might be shifting from an increasing to a decreasing trend 6 , 37 , 38 .

None of these variants were genome-wide significant in our data, but 8/11 showed nominally significant association p values, with the allele decreasing serum B12 levels consistently also increasing the risk of pernicious anemia (Supplementary Data 5 ).

A few areas appear to have experienced a small trend over 1993–2015, mainly in the mid to high latitudes: e.g., the west coast of North America, Northern Europe, most of South America, and South Asia.

Our results show an increasing trend in overtopping, resulting in almost a factor 1.5 increase in globally aggregated annual overtopping hours from 1993 to 2015.

As mentioned previously for the rat model, adhesion coverage also shows a decreasing trend from 3 to 6 weeks in the porcine model, which is commonly observed in patients.

Single-cell enrichment analysis of deleterious gDNMs in BD The above analysis integrating transcriptome data of bulk tissues showed an overall trend that the genes hit by deleterious gDNMs in BD are enriched for brain-expressed genes with a prenatal bias; however, we could not specify single brain regions with robust significance.

However, this result contrasts with recent results showing that tyrannosaur juveniles outcompeted smaller theropods 109 , although we estimated marginally non-significant competition in North American carnivores (tyrannosaurs over dromaeosaurs; Supplementary Table 3 ).

Unsurprisingly, Chlamydiaceae show a highly significant association with animal host-associated microbiomes (Fig. 6b ).

At 6–8 weeks post TAM, LOH tumors showed a trend toward increased tumor numbers and significant increases in tumor size compared to both “no LOH” control groups (Fig. 1c, d ).

It was difficult to quantify this improvement based on data recorded in the caregiver diary for most cases, but an overall trend towards an increase in the number of hours of sleep per night can be observed, and for Subject 2, the improvement in sleep quantity was dramatic (Fig. 4d ).