Excerpts

1 ) revealed a highly significant decrease in Asian ancestry (and corresponding increase in African ancestry) on chromosome 1 near the locus 1q23.

In addition, there was a highly significant association between levels of expression of CDCA7 and DSS (trend test P = 1.22 × 10 −8 ), which maps just 7 kb from the reported 2q31.1 risk SNP (rs1550623), but while there was a robust eQTL association between rs1550623 and CDCA7 in all cancers (trend tests: nominal P = 0.007, FDR adjusted P = 0.09) there was no association in ER+ cancers alone (both P > 0.1).

Two of the three DN-1 infected animals showed a trend toward viral enrichment in the brain although the mean levels were not significantly different compared to DN-2-infected animals.

The interaction term between forest loss and taxa type (Model 3) was marginally significant (Table 2 ) with elevational range shifts being lower in magnitude for plants than for animals under high forest loss (Supplementary Fig. 1 ).

P -values above or equal 0.05 were classified as not significant (ns), between 0.05 and 0.01 as significant (*), between 0.01 and 0.001 as very significant (**), between 0.001 and 0.0001 as extremely significant (***) and below 0.0001 also as extremely significant (****).

1b , there is a clear trend showing that the more recurrently mutated a gene locus is, the larger the fraction of proteins showing statistically significant correlation between metaVIPER-inferred protein activity and mutational state.

Highly significant correlations were observed bilaterally in the VS and DLPFC ROIs.

In fact, at 6 weeks post-administration of the higher AAV dose, Pcsk9 transcript levels were indistinguishable from non-treated controls and serum protein levels displayed an increasing trend relative to earlier time points.

The reperfusion amplitude also showed a trend of decline in non-responders and elevation in responders (Fig. 5h , Supplementary Fig. 9E ).

In this study, given the large sample size and the highly significant effects identified, we further investigated the sex-by-SNP interaction for the 20 loci associated with tanning ability.

Let us suppose that for a given phenotype there is only one causal SNP and that the GWAS yielded a highly significant p -value, say 10 −50 .

P < 0.05 was considered as statistically significant (*) and P < 0.01 as highly significant (**).

Notably, the result obtained using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed a highly significant association of inflammatory diseases such as cytokine–cytokine receptor interaction, TNF signal pathway, Jak-STAT signaling pathway, rheumatoid arthritis and IBD.

Finally, for both the number of persons affected and monetary losses adjusted for inflation, a positive trend is observed over all periods of record.

In contrast, the number of fatalities is available for almost all flood events in the database and a negative trend of at least 1% per year is observed, even though it is only statistically significant for the period between 1950 and 2016 (see Methods section for statistical significance testing procedure).

Moreover, the normalized monetary value of losses after gap-filling no longer shows a significant trend for the whole period, and losses normalized by wealth increase by only 0.2% per year, while normalized by GDP decline by 0.1% per year.

Despite this, we observed only a modest (though highly significant) effect; intelligibility in mixtures clearly does not completely fall apart.

This analysis revealed a highly significant increase of some Met(O) peptides compared to Met peptides of ATP synthase subunit β on oligomer treatment.

This is because vesicles with a size comparable to the wavelength of light, i.e., sizes > 1/10 the wavelength of light, stop acting like point particles and show a decreasing trend in scattering intensity with increasing volume 29 at the scattering angle used for measurements (90 ° ).

3 confirms it, as both the patients’ simulated BCI performance with a fixed, conservative threshold, and the actual confidence threshold exhibited a slightly increasing trend.

By focusing on interactions in regions of borderline significant genetic associations, we were able to identify potentially physiologically relevant target genes of GWAS SNPs through functional rather than proximity considerations.

Interestingly, mean annual body mass of juveniles corrected for seasonality also exhibits a negative trend over the study period, and these data also show a much better fit to an OU-model than to a neutral model (Supplementary Table 2 , Supplementary Figure 3 ).

No significant differential methylation of MAPT Analysis of the region 17q21.31 that spans 1.6 Mb (43,470,000 to 45,061,000 on chromosome 17) and includes MAPT revealed nominally significant methylation differences at 11 sites.

While methylation differences only affect one or a few sites at most genes, highly significant ( ≥ 5%) hypermethylation is found at multiple sites associated with the gene DLX1 .

However, when normalized to protein input, mass spectrometric analysis of purified myelin demonstrated a highly significant reduction by >50% of nearly all classes of lipids in CMT rat myelin (Fig. 5c ).