Excerpts

The δ 18 O records from northern MSEA and Sumatra instead show decreased values during the early Holocene and an increasing trend after (Fig. 2d, e and h ), which is consistent with summer rather than autumn insolation.

S1 ); however, the range and resolution of distance to hospital data were not enough to identify a strong trend.

We also observe an increasing trend indicating that the insertion gain increases with the optical depth of the medium.

Nevertheless, despite this additional reactivity, from these experiments a clear trend can be defined: increasing the substituent length at the para -position from a methyl to an ethyl, propyl, butyl, or pentyl functional group is correlated with lower total turnover numbers (Fig. 3d ).

These data reveal an overall trend whereby axon extension of the medial vs medial, lateral vs lateral and commissural vs commissural projections may have fixed rates in absolute time, being broadly comparable between species in absolute days.

In Argentina, diversity appeared to decrease between 1989–1999 and 2000–2012 before increasing again in 2013–2019, with an overall trend of increased pathotype diversity over time (Table 2 ).

For further analyses between genes with pLOF variants and our proteomic dataset, we considered 95 AB, 161 PH and 7 PPI genes as moderately significant genes with pLOF variants associated with severe disease (FDR < 0.1) to include more genes with smaller effects (Fig. 4B–D ).

Interestingly, an increasing trend of H 2 evolution was observed for the Pt/TiO 2 samples, which can be attributed to a progressive Pt reduction under photoreaction conditions.

3a , show a clear trend indicating that the photothermal synthesis requires lower temperatures to achieve nucleation and produce similar-sized nanoparticles (Supplementary Fig. 29 ).

The overall results showed a weak trend of decreased stained surface in group 17 compared to 11.

Quantitative image analysis results showed a trend of decreased stained surface in group 17 compared to 11 (Fig. 6a ).

Inhibitor treatment for 48 hrs decreased expression of Smgc and addition of ligands showed an increasing trend although not significant compared to washout alone (Fig. 7b ).

As the D S increases continuously, the contact angle hysteresis shows an increasing trend, indicating the increased critical resistance at the laser-ablated groove.

There is a clear trend for lower mutation rates in poikilothermic vertebrates than in homoeothermic species because the three species with the lowest hitherto reported mutation rates are all fish (Fig. 8 ).

7a, b , the levels of each of four measurable oxyl-cardiolipins as well as total oxyl-cardiolipins were significantly higher in Lcn2 KO mice in the basal condition and had an increasing trend in the CL316, 243-treated condition.

Serum-free fatty acid levels had a decreasing trend in WT mice by CL316, 243, but no change in Lcn2 KO mice (Supplementary Fig. 1g ).

15 , we found a decreasing trend of TDP-43 binding to RNA in most of the transcripts, where alteration in the variant resulted in significant changes of binding events in the high-attention region; for example, in transcript ENST00000547986 from K562 cells shown in Fig. 8 a, a mutation of the poly-U binding peak at position 94,971

Changes in atmospheric circulations around Europe that favor heat were also emphasized 20 , 21 , in particular a positive trend in a dipole structure with a low pressure over the Eastern Atlantic 22 , 23 and a high pressure over the Mediterranean extended towards central Europe 24 .

Hepatic ketogenesis intermediates Aceto-Acetyl-CoA and HMG-CoA showed a nonsignificant trend toward lower expression in Fbxw7-null livers (Supplementary Fig. 6k ), likely because they are also involved in the mevalonate pathway.

However, when adjusting for the top SNP (rs6914651) in the regression model, neither HLA-DPB1*03:01 or HLA-DPB1*04:01 were nominally significant, suggesting that it might not be a specific HLA-DPB1 allele that affects AU risk (supplementary Data 7 ).

Three additional genes exhibited borderline significant p values and represented results from extremely rare gene-burden masks that consider only variants appearing once in each cohort (singletons).

We investigated this by a simple and interpretable orthogonal analysis, calculating the number of cell lines crossing a nominally significant RRA < 0.05 for each drug (Fig. 2b and Supplementary Data Fig. 2e ) and for each cell line (Fig. 2c and Supplementary Data Fig. 2f ).

We used t-SNE 28 and UMAP 29 to cluster the data, revealing an interesting trend, with the data primarily clustered by cell line, rather than by drug or outgroup status (Fig. 2a ; Supplementary Data Fig. 2a–d ; UMAP parameters were selected using an automated Monte Carlo approach, see Methods).

For the z-SDMs of Al-Al pairs, there is an obvious trend to be close to the signature of D0 3 -CSRO except zone 1.

Second, the whole lungs of JHU083-treated Mtb -infected mice showed a trend toward diminished glutamine pools while the cancer data showed an accumulation of glutamine in the tumor microenvironment as measured in excised syngeneic, solid tumors taken from the flank.