Excerpts

Both SynergyLMM and invivoSyn yielded similar results, indicating significant or nearly significant Bliss synergy for the three colon cancer models.

Four weeks after the injection, MARVEL showed a trend of higher endothelial transduction than RBC/AAV (Fig. 4D) and a significant increase in epithelial transduction (Fig. 4E ).

In this case we saw a clear trend of stronger effects in more superficial layers (Fig. 4g ).

19 , UV-visible-near-infrared spectra of ClO – generated from CoP/NF, Co-Pi@CoP/NF, and MnO 2 @Co-Pi@CoP/NF after 50-h and 100-h electrolysis at 1 A cm –2 reveal a clear trend: MnO 2 @Co-Pi@CoP/NF produced the least amount of ClO – , followed by Co-Pi@CoP/NF, while CoP/NF produced the most, confirming that MnO 2 @Co-Pi@CoP/NF exhibits the improved selectivity.

Thus, the integration of multi-modal data (e.g., text descriptions, amino-acid sequences, protein structures) represents a significant trend in the development of protein design models.

In analyses of astroglial/neuronal injury and AD-related blood biomarkers, the Cog-PASC group showed a trend toward higher GFAP levels, although this did not reach statistical significance.

Calculating the relative strength of the TSS hotspot for all disease gene sets listed in the Human Phenotype Ontology 69 , we found highly significant associations ( p adj < 10 −50 ) with over 20 neoplasms and carcinomas (mean Jaccard index JI=0.22), decreased mitochondrial activity (two phenotypes; JI=0.52), seven neurological phenotypes (JI=0.18) and defective limb development (three phenotypes; JI=0.11), Fig. 5 c.

A clear trend emerges: the decay of Cu 6 -THF (Fig. 5e ) is significantly slower than that of Cu 6 -DCM (Fig. 5g ), while Cu 6 -AC (Fig. 5f ) shows intermediate behavior.

The chromosome 2 variant rs35203651 was also nominally significant in the European subgroup replication.

At the gene level, we identified six (four with borderline significance) susceptibility CS-related genes, including FCN1 , which is expressed in leukocytes and involved in elastin-binding 21 , 22 ; PLAT converts plasminogen into plasmin, crucial in cell migration and tissue remodeling/degradation 23 ; CD46 protects host cells from complement self-cell damage 24 , 25 ; F2RL2 is key in thrombosis 26 ; VTN promotes cell adhesion 27 and inhibits the MAC 28 ; and A2M , which works as a protease inhibitor 29 , 30 .

This transition arose as the halosteric height maintained a positive trend throughout the 2011–2025 period, while the thermosteric height rebounded from its decline in response to the 2012–2025 convective cycle’s phase change (Fig. 2 ).

Values of the type-I error rate ( p ) <0.05 were considered statistically significant, and p < 0.01 and p < 0.001 were characterized as highly and very highly significant, respectively.

However, with the widest prior ranges (60 and 80), the relative risk estimates associated with NA and HA stalk were less precise, with credible intervals overlapping 1, suggesting borderline significance.

When the mean incubation period increased from 1 to 2 days, some borderline significant parameters—such as the effect of HA stalk on susceptibility and NA on infectivity—shifted slightly above 1 in the upper value of the 95% credible intervals.

In line with knock-down by siRNA, treatment with the calcium channel blocker drug nicardipine 55 or AOX1 inhibitor drug raloxifene 56 also showed a trend towards increased HDR when combined with M3814 (Fig. 3h ).

5C ), a proxy for addition of sediment-derived melts 42 , 68 , defining a positive trend.

These increases were preferentially more medially distributed and showed a trend toward the anterior portions of the striatum.

Since the associations at this locus were highly significant, we looked for variants that might affect protein structure and function.

Sedimentary archives from the ECS reveal a striking divergence: while δ 13 C org exhibits an increasing trend, 10 of 13 cores show coherent declines in δ 15 N from the early 1900s to present, with an average rate of −1.09 ± 0.48‰ per century (Supplementary Figs. 8 and 9a–b ).

Conversely, a weak trend between MW and toxicity suggests that heavier compounds are less toxic.

A statistical trend for an association with mood was further detected for the AAA ( t = 2.6, p uncorrected = 0.011, p corrected = 0.061, subpart 9, light green on Fig. 2A ) and the intercalated nuclei ( t = 2.46, p uncorrected = 0.016, p corrected = 0.089, subpart 10, green on Fig. 2A ) (Fig. 2L, M , Supplementary Table S4.d ).

Accordingly, we subdivided the compiled Ordovician Δ 199 Hg profile into four intervals, including (1) a decreasing trend of Δ 199 Hg values during the early Tremadocian to middle Floian (~485-473 Ma), (2) a dominance of near-zero Δ 199 Hg values during the late Floian, followed by a decreasing trend from positive to near-zero values during the earliest to early Dapingian (i.e., the LFCE) (~473-468 Ma), (3) a gradual

7 ) shows a decreasing trend in work function (WF) across the support materials: CeO 2 (5.79 eV), CNTs (4.91 eV), and CeO 2-x /CNTs (4.71 eV).

As satellite retrievals and reanalysis products indicate a positive trend in Q v near the surface over the last four decades 41 , the connection between water vapor and σ W explains some of the positive trends depicted in Fig. 1 .

However, the D208N mutant showed a clear trend towards hexamer formation even before incubation, with the hexamer fraction becoming dominant at equilibrium (Fig. 2f , middle).