Excerpts

For specific disease milestones, a highly significant model resulted where the old-old PD patients were 15.7 times more likely to develop dementia, 9.8 times more likely to be wheelchair dependent, 3.1 times more likely to be hospitalised in the past year, and 4.6 times more likely to be in residential care than the young-old patients.

While the current population has a decreasing trend [ 16 ], the most critical issues relate to the potential loss of the last isolated micro-populations surviving in West Africa and the similarly endangered small populations in Central Africa.

o In order to clarify this, we have added the following in the “Synthesis methods” sections of the Methods subheading: “heterogeneity was arbitrarily categorized using cutoff points agreed by the authors as not important (I2 < 40%), moderately significant (I2 = 40%–75%), and considerable (I2 > 75%)” Review Comments to the Author Reviewer #1: • Gonzales-Huaman and co-authors performed a systematic review about peri-abortion contraceptive counseling interventions.

A slight trend toward reduced rates of proliferation were observed in the HTN (+) HFpEF group but did not reach statistical significance.

In all the models allowing for the interaction ( hypothetical#high_anchor_interaction ), it was highly significant, while the main anchoring effect was not.

CPL and LW exhibited extremely significant negative correlations between all pairs of physiological traits; Chl presented significant positive correlations with LP and LN, and PRO was significantly negatively correlated with CLW and LA (P<0.05).

Whilst there are no significant initial differences between the pristine and heat-treated samples, 106.9°±6.8° and 111.9°±15.1°, respectively, both samples show a decreasing trend over time.

Severely co-morbid patients (CCI≥5) and those in the frail MRP subgroup, showed a trend for a worse OS but without statistical significance (p = 0.08 and p = 0.094, respectively).

The starch content of mother bulb showed a trend of increased firstly, then decreased, and then increased again from the flowering stages, half withered stage and withering stage, respectively ( Fig 3B ).

The Mann-Kendall test highlighted a significant trend of increasing dengue cases for the Brazilian states Federal District (DF), Goiás (GO), and Minas Gerais (MG).

An increasing trend was noted in all lines with increasing application of Ni level in an external environment ( Fig 3C ).

The results ( Fig 1C ) demonstrated highly significant increases specifically in the levels of α-secretase-generated C83 of 2.44 ± 0.18- and 2.14 ± 0.12-fold, respectively, in lysates prepared from 10 and 20 mM DCA-treated cells (relative to untreated controls).

Simple effects bordered on significance, showing a pattern that those that were relatively deprived in the card game and also experienced higher chronic relative deprivation appeared to select a higher number of rewarding foods.

In our cohort, we see a positive trend when correlating increasing creatinine with PCT although a rise in PCT remains noted in the setting of true infection.

Only evidence of severe sarcopenia, even if sarcopenia was not confirmed by BIA, correlated with the Barthel-dependence scale and approached significance with the Frail-fragility scale.

Methods/results – how do the authors define “borderline significance”?

In addition, the application usage data showed a decreasing trend in percentage of patients who read the motivational messages over time.

Notwithstanding, an increasing trend in mange distribution and infection prevalence has been recently reported for vicuñas in several countries across their range [ 30 , 62 , 63 ].

Overall, spring migrants also showed similar haematological profiles, with the only difference being a decreasing trend of H/L ratios across the season.

A decreasing trend was observed only in municipalities with very high social vulnerability for Income and Work (APC −1.8%).

Only the state of Minas Gerais showed an increasing trend, whereas nine other states showed a stationary trend.

Rainfall time series between 1964–2015 at latitudes 9°, 12° and 13° South encompass the cities of Paulo Afonso-BA, Sobradinho-BA, Bom Jesus da Lapa-BA and Irecê-BA, indicating a decreasing trend in precipitation by the Student t-test.

Thus, there is an increasing trend in sea surface temperatures over the Tropical Atlantic shifting the ITCZ northward, reducing rainfall south of the Equator [ 27 ].

Although the PDI value of the KPEVs did not significantly change in repeated freeze-thaw cycles, the heterogeneity of the KPEVs had an increasing trend ( Fig 4A , right).

As expected, when analysing a relatively small number of patient samples, variance is high, but with a clear trend for increased values for all measured markers.