Excerpts

For instance, nine of our candidate cancer genes were also contained in the Cancer Gene Census list, which comprises 487 genes causally linked to cancer [ 11 ], representing a highly significant enrichment ( Abl2 , Braf , Fbxw7 , Foxp1 , Ipo11 , Mllt3 , Fas , Pten , and Nf1 ; p<0.0002, Fisher’s exact test).

A highly significant positive correlation was observed across groups between the levels of Aβ-IgG immune complexes in CSF and serum ( r = 0.54, p = 0.0002; Figure S2 in the Supporting Information).

Age effect was extremely significant (F (1, 68) = 15.51, p = 0.0002).

Methodological Quality Methodological quality as assessed by the Jadad score increased significantly over time (P<0.0001); we also reanalyzed the data minus the first period (1948–1953) (where the average Jadad score was much lower) and the increase over time was still highly significant (p = 0.0002) ( Figure 4 ).

With age included as a covariate and using the Tukey-Kramer adjustment for multiplicity, the comparison between CH-NATs and AD was highly significant (p = 0.0002) whereas the comparisons between CH-PATs and CH-NATs and between CH-PATs and AD were not significant (p = 0.09 and 0.12, respectively).

The amount of FD4 diffusing through the monolayer (measured by the permeability coefficient, P app ) treated with TGFβ3 was about 10fold higher (highly significant, p = 0.0002) compared to an untreated monolayer ( Fig. 2 ).

The gender difference is highly significant (t(62) = 3.83, p < 0.0002, two-tailed, with an effect size Cohen’s d = 1.025).

Apparent survival The U-CARE goodness of fit global test was highly significant (χ 2 = 36.93, d.f. = 12, p = 0.0002).

The interaction between intruder x resident genotype was also highly significant (F 2,40 = 10.71, p = 0.0002).

More precisely, a clear differentiation in the overlap type groups is evident, as both F-tests and P-tests [32] are highly significant (for F -test: p<0.0002; for P-test: p<0.001) which is further supported by the high bootstrap values obtained between the clades ( Figure 2 and Figures S1 and S2 ).

The results remained highly significant (p=0.0002).

However BSO has a highly significant (p = 0.0002) effect in these cells when used in combination with 8 μM ATO.

As demonstrated in Fig 4B , 12 out of 18 (66.7%) patient samples showed a highly significant increase in plasma CgA levels (P = 0.0002) during tumor progression which was in total nearly nine times higher (mean increase of 291.3 U/l) compared to samples derived from patients with NEN of the colon and rectum.

The difference in numbers of the competitors between the two time periods at the 1900 m site was highly significant ( Χ 3 2 = 20.1, P = 0.0002).

All correlations are highly significant (p<0.0002), indicating the null hypothesis that the correlation is equal to zero can be rejected.

With the exception of the consumer price index, all the nominally significant variables displayed in Text S1 (Table A) remained highly significant (P<0.0002 or lower) after Bonferroni correction for multiple testing.

Applying the GEPHAST analysis separately to each of the three groups defined by STRUCTURE (assuming each group to be homogeneous) reveals a striking pattern in which both INRA111 and BMS2753 yield highly significant associations in just one of the three groups (P = 0.0002 and P = 0.0005 respectively, corrected for 30 tests).

Noteworthy, RA-related phosphoprotein profile changes are unique to the CD19 + CD27 − IgD + IgM low/− subset of autoreactive B ND cells: nominal logistic fit demonstrated that RA predictive value of the combined phosphorylation profile of several major BCR signaling proteins and Ca 2+ levels in response to BCR stimulation [2] in B ND cells was highly significant (R 2 = 1.0, p = 0.0002), while in mature naïve CD19 + IgM + B cells this predictive value was substantially less evident (R 2 = 0.505, p = 0.053).

Though this gene has been used in the literature [ 39 ], performance of this gene in our mouse panel was mediocre, and as shown in Fig 6A , the raw (non-normalized) data for B2M in our mouse muscle dataset does appear to suggest a highly significant (P = 0.0002) increase in B2M expression in dystrophic tissue.

[22] demonstrated that there was a significant trend for increased folate intake to be associated with a lower risk of lung cancer in men (P = 0.0002), and the multivariate RR for the participants with tertile 3 folate intake was 0.70 (95% CI, 0.55–0.89) when compared to those with tertile 1 folate intake.

Results and Discussion Metabolites and isotopic signatures With increasing CH 3 F concentration, acetate accumulated while methane accumulation was reduced accordingly ( Figure 2A ) resulting in a highly significant negative correlation (r = 0.7, P = 0.0002).

We find that there is a highly significant correlation between carrier status weighted by either acetylcholine EC 50 (β = −0.67, r 2 = 0.017, P = 2×10 −4 ) or by response to low nicotine (β = −0.29, r 2 = 0.02, P = 6×10 −5 ) when variants are expressed with the α3 subunit.

Polygenic risk scores (PRS) for reproductive aging phenotypes and breast cancer risk The correlations between the PRS for each reproductive aging phenotype and the phenotype itself were highly significant as expected (p≤0.0002); yet the strength of the correlations was weak (correlation coefficient 0.16–0.21) ( Table 6 ).

In contrast, the difference between APU and APP on edibility ratings was highly significant (F[1,58] = 16.025, p<0.0002; power = 0.987) ( Figure 1d ).

Three markers were nominally significant (P-value = 0.00021–0.011; Table S7 ).