Barely Significant

Excerpts

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While an OSM-dependent action of osteoclasts and macrophages may be significant for MSC recruitment it is unlikely to explain how bone formation is stimulated by osteoclast-initiated remodelling unless other factors either direct MSC to the site of osteoclast activity or provide an amplifying co-stimulus for OSM action.
highly significantqualifiedgold
Although TOX3 falls out of the minimum LOH region, in view of the highly significant association of rs3803662 with breast cancer risk, we hypothesised TOX3 to be a likely candidate tumour-suppressor gene present on the 16q arm.
TOX3 mutations in breast cancer.
PLoS One · 2013 · PMC3777980