Barely Significant

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Interestingly, AF patients above the age of 70 years observed approximately 40–50% reduction in stroke risk (both ischaemic and haemorrhagic) when prescribed a DOAC compared to warfarin, with the exception of AF patients above 90 years of age who showed a trend for an increased risk of haemorrhagic strokes when prescribed a DOAC ( Fig 2C ).
The combinations of mexiletine plus dofetilide and of lidocaine plus dofetilide generated sigmoid-like effect profiles, which were similar in shape to the ranolazine effect profile in Study A: The 10% to 40% quantiles were negative with a transition to positive in the mid-repolarization phase, and a slightly increasing trend up to the 100% quantiles.