Barely Significant

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borderline significancep = 0.0551.1× alpha
S1c ). We employed the PI3K signature score developed by Gustafson 29 , as a measure of PI3K pathway activation, on the set of paired primary and metastatic tumors, and found a tendency of increased PI3K activation in metastases (borderline significance of p = 0.055; Fig. 4c ).
a strong trendp = 0.0551.1× alphagold
The pathways analysis outcome between 10 weeks and 6 weeks old 5xFAD mice showed a clear upregulation of immune system related pathways such as interferon-gamma signalling pathways and a strong trend for altered B and T cell activation pathways and interleukin pathways in the 10 weeks old 5xFAD mice (p = 0.055, p = 0.071, respectively) which goes along with the alteration of cytokines we detected in 10-week old 5xFAD brains.