Excerpts

The SAFT90 protocol showed borderline significance (pre: 7.46 ± 1.55, post: 6.53 ± 1.36; Z = 2.941, raw p = 0.003, ES = 0.50) (Fig. 7 C).

The deficiency of female fetuses was not statistically significant in the AI group (p = 0.20) but was highly significant in the IVP group (p < 0.003) when compared to the binomial distribution with the expected 1:1 sex ratio.

Our data on the decrease of BMI are important and highly significant (p = 0.003).

Only the stroke group showed a highly significant difference when both time points were compared (Z = −2.936; p = 0.003), indicating the functional deficit after stroke.

The female had no significant effect (F 1,79 = 2.34, p = 0.130), but there was a highly significant effect of the male × female interaction (F 1,79 = 9.52, p = 0.003), because interspecific matings were shorter.

However, the proportion of MDSCs among total urinary cells significantly decreased in the non-recurrence group, whereas it did not decrease in the recurrence group and instead showed an increasing trend ( p = 0.003) (Fig. 3 ).

Additionally, Spearman's correlation showed that a negative moderately significant associations were found between deletion size and 5′ LIR number ( r s = −0.30, P < 0.003), and 3′ LIR number ( r s = −0.30, P < 0.002) in 109 gross deletions respectively.

Comparative analyses of functional connectivity strength within the four regions of interest (ROIs) and among the six ROI pairs in the two athlete groups demonstrated highly significant differences in correlation coefficients for PFC-L ( P = 0.003, Hedges’ g = 1.48, 95% CI[0.74, 2.22]), PFC-R ( P = 0.003, Hedges’ g = 1.49, 95% CI[0.75, 2.23]), M1-R ( P = 0.003, Hedges’ g=−1.34, 95% CI[−2.07, −0.61]), PFC-L-PFC-R ( P = 0.004, Hedges’ g = 1.50, 95% CI[0.76, 2.24]), and M1-R-M1-L ( P = 0.001, Hedges’ g=−1.77, 95% CI[−2.26, −0.98]).

The trend slope changed in a decreasing manner (− 0.798, 95% CI − 1.233 to − 0.363, p-value = 0.001), resulting in a decreasing trend of − 0.622 cases (p-value = 0.003).

While on a per-study level, this analysis failed to reach statistical significance, but for the proportion of ATTRv patients in ATTRACT, among the three trials, a highly significant tendency towards a higher proportion of male ( p = 0.003) and ATTRv ( p = 0.016) participants and was observed.

Notably, a significant trend was observed across the different CAR categories ( P = 0.003; Table 2 ).

As shown in Table 2 , high WTAP expression was identified in 44.7% (84/188) of cases with tumors larger than 2 cm and in 28.9% (46/159) of tumors ≤ 2 cm; the between-group difference was highly significant ( P = 0.003).

Note that the 3-way interaction remains highly significant (p = 0.003) when controlling for female age (which has a strong effect on miscarriage rates in this population) 20 .

Linear regression analysis shows that this trend is highly significant for each group, and the magnitude of that drop is also similar for each group: for controls the change in temperatures was −0.173 °C/day (p = 0.003); for doxorubicin −0.274 °C/day (p < 0.001), and for ICT-2552 −0.199 °C/day (p = 0.005).

The difference between Ntf3 and negative control wells was highly significant (p = 0.003).

A highly significant hearing disturbance was detected around 24 kHz (42.1 ± 9.1 in +/+ vs. 74.3 ± 8.4 dB in −/− , p < 0.003, Fig. 1 A).

Heart rate showed a trend towards a difference between groups and an interaction with time (Repeated measures ANOVA, Effect of Time: F 1,56 = 9.46, η 2 = 0.0082, p = 0.0032; Effect of Group: F 1,56 = 3.60, η 2 = 0.57 p = 0.063; Interaction F 1,56 = 3.45, η 2 = 0.003, p = 0.069).

This is a highly significant difference compared to group 1 (65.8%; p = 0.0032) and group 2 (64.5%; p = 0.0029) (data not shown).

Similarly, SSIM-based stability analysis demonstrated highly significant gains (p = 0.0033), confirming improved visual robustness and reproducibility of explanations.

Meanwhile, we also observed a highly significant negative correlation between the expression level of miR-429 and CRKL (R 2 = 0.5905, P = 0.0035, Fig. 2C ).

This data was confirmed in A431 cells using flow cytometry showing a highly significant 4.5 fold increase in intracellular fluorescence (Fig. 2 ), P = 0.0036.

The ms/blink RT and the participants’ RT show a positive trend of longer reaction times for more memorized items, p = 0.0037 , p = 0.06 ( n.s. ) , and p = 0.00001 , respectively.

The ANOVA of the Plackett-Burman design demonstrated that the model was highly significant as was evident from the Fisher’s F -test value of 23.55 with a very low probability value ( P -value = 0.0038) (Table 3 ) implies that the terms are significant.

In NC114-treated hearts, both genes were significantly downregulated at 1 week post-TAC, whereas at 4 weeks they exhibited downward trends that did not reach statistical significance (log2FC = –1.99 and –3.18; adj. p = 0.0039 and 0.0179 at 1 week; log2FC = –1.16 and –3.20; adj. p = 0.0722 and 0.0529 at 4 weeks; data from Supplementary Materials, RNAseq_NCVH_1wk.xlsx and RNAseq_NCVH_4wk.xlsx).

Unexpectedly, we observed a decreasing trend of within-group-averaged r 2 (i.e., six samples from 6 different threshold levels) as the motion threshold level became less stringent (Fig. 4 C; r = − 0.95, p = 0.004).