Barely Significant

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Six SNPs had nominally significant associations to more than one endpoint. rs11082257, an intronic SNP in PIK3C3 on chromosome 18q12.3, was associated with decreased risk for any IA (HR = 0.88, 95% CI 0.78–0.99, P = 0.031), mIAA-first (HR = 0.76, 95% CI 0.62–0.93, P = 0.008) and T1D (HR = 0.79, 95% CI 0.65–0.97, P = 0.022). rs301707
The estimates derived from the inverse probability weighting model for descending transition patterns remained statistically significant, with ORs of 2.2 (95% CI 1.32, 3.79) for maternal overweight at pre-pregnancy, 3.89 (95% CI 1.25, 12.06) for infant overweight at time 1, 4.16 (95% CI 1.40, 12.28) except for maternal educational history, which had an almost identical estimation but fell just short of statistical significance (OR 1.12; 95% CI 0.99, 1.26).