Excerpts

Finally, note that RRF was actually so fast at small chunk sizes that there was a significant overhead associated with our parallelization of the algorithm (Methods), as linear models fitted to only chunk sizes less than 200 were highly significant ( P <2.00×10 −16 ), with negative slopes (Fig. 1 b).

Thus, it is not surprising that the separation of nationalities due to the co‐dispersion along these two axes is highly significant (MANOVA: P < 2e–16).

The variation in ancestry seen in the admixture maps of Figure 1 also result in highly significant correlations of the three ancestries with altitude of birthplace (p-values <2×10 −16 for the three ancestries): African and European ancestry decreases with altitude (r of −0.24 and −0.39, respectively), while Native American ancestry increases (r = 0.48).

However, the overlap between these two very different approaches is highly significant (Fisher's exact test, p < 2 × 10 −16 ), and the functional enrichments they identify are similar (see below).

The association between miR-100 and EMT markers was further validated in human tumors: from the Cancer Genome Atlas (TCGA) breast cancer data [17] , we observed a moderate but significant inverse correlation between miR-100 and E-cadherin expression levels ( Rs = −0.1, P = 0.006, Figure 1F ) and a highly significant positive correlation between miR-100 and vimentin expression levels ( Rs = 0.43, P <2×10 −16 , Figure 1G ). miR-100 suppresses tumor growth and is downregulated in human breast cancer We performed TCGA data analysis to determine the expression levels of miR-100 and miR-22 in human breast cancer.

The Fligner–Killeen test of homogeneity of variances is also highly significant ( p < 2 × 10 −16 ) between ht-UtLM6 and CR-LM6.

This overlap is highly significant ( P < 2 × 10 −16 ).

The enrichment of TEs at species-specific binding sites were highly significant both with a chi-square test (Hs χ 2 = 142.8, Mm χ 2 = 131.4, both p < 2e −16 ) and with permutation tests (n = 10,000, p < 1e −5 ) ( Fig 5A ).

A model without interaction showed a highly significant effect of voxel on spectral quality ( Fig. 3 a ; F (1,79.12) = 183.73, p < 2 × 10 −16 ), with LO linewidth broader than EVC.

Vials of APSA stored on ice in the fridge for up to 22 months and then sampled at a dilution factor of 1/250,000 (DF 250,000) prior to assay showed extreme sample to sample variation in enzyme activity and a trend to lower OD values over time with a highly significant effect of the storage time on the detection limit (ANOVA p ≤ 2E-16, Regression p < 0.043) ( Fig. 2 A).

In the total Cape Verde sample, skin pigmentation is significantly correlated with individual ancestry, with a clear trend towards darker pigmentations with increasing levels of West African ancestry (Pearson r = 0.54, P -value <2e–16; including sex as a covariate).

We repeated the moving average analysis (see Materials and Methods) comparing the distribution of mutations in the HS cluster and WT V regions and again found a highly significant positive correlation ( r = 0.52, P < 2 × 10 −16 ).

An analysis using Pearson's correlation coefficient indicates a highly significant linear relationship between bioactivities measured against human and rat targets (r = 0.71, p<2e-16).

Interestingly, in all tumors FOXP3 expression is highly significant, positively associated to GZMB expression levels ( p -value = 2.0E-16) Adaptive immune response strongly depends on the B cell response.

The difference in this distribution was highly significant ( χ 2 p-value<2e-16).

The highly significant (β = 2.02, z = 45.64, p < 2 × 10 −16 ) intercept, the model estimate of around 8 roadkill, shows a strong baseline effect for predictors at their reference values.

We found the effect of rurality to be highly significant ( P < 2.0 × 10 -16 ), but it explains only 28% of the overall variation in log positional error magnitude.

Compared with dense forest, analysis of the variance between these three habitats reveals a highly significant difference ( p ‐value < 2e‐16).

The correlation between CpG O/E and gene length is highly significant (Spearman’s r = 0.47, P < 2 × 10 −16 ).

The intercept had an estimated coefficient of 0.8443, which is highly significant (p < 2e-16), indicating a strong positive relationship between the dependent variable and the constant term.

Across the 38 weeks of the study, the percentage of reactive cases per week showed an increasing trend (value of p < 2e-16), ranging from 0.4% (95% C.I.: 0.11–1.47%) in the second week to 41.9% (95% C.I.: 26.4–59.2%) in the last week ( Figure 1 ).

This shift is highly significant compared with either the simulated random distribution ( p = 2 × 10 −16 ) or the distribution from the glucose-grown cells ( p = 2 × 10 −11 ; Wilcoxon rank sum test).

In contrast, Sunitinib had a strong and highly significant effect on the fusion index of 54.12 cells at all concentrations tested (p<2 × 10 –16 ).

Result After controlling for baseline age, sex, education, APOE ε4 dosage, and self‐reported race, IFI44L genotype strongly associated with clinical trajectories in clinically normal (CN) individuals and those with mild cognitive impairment (MCI) in the ADNI cohort, with the rs273259 alternate (G) allele displaying a highly significant, dose‐dependent relationship with worse clinical trajectories (for CDR‐SB, in CN, p < 2 x 10 ‐16 ; in MCI, p = 1.1 x 10 ‐6 ; Figure 1A‐B).

Using the aggregated network, we observed that the number of first-degree protein partners was higher in selected MR gene-traits as compared with gene-traits that did not reach statistical significance ( p < 2e−16).