Excerpts

To statistically confirm the effectiveness of this discrimination, we also conducted an ANOVA test, which showed a highly significant separation among the groups (F 2, 117 = 355.6, p < 2e –16 ).

General linear model showed that clinical symptoms have a highly significant effect on the number of cMBs (N = 2.78, 95%CI [2.51–3.07], p<2*10–16; ndf = 78, AIC = 1218).

Using the aggregated network, we observed that the number of first-degree protein partners was higher in selected MR gene-traits as compared with gene-traits that did not reach statistical significance ( p < 2e−16).

Statistical analysis using one-way ANOVA confirmed a highly significant effect of treatment on fungal growth (F(20, 42) = 56.52, p < 2 × 10 −16 ).

This highly significant relationship ( p = 2e−16), with a slope of 2.37 ± 0.05 (Fig. 6 ).

In parallel, a linear model assessing the direct association between mean relative abundance and response demonstrated a highly significant positive effect (estimate = 0.30, P < 2.0e−16), with dataset terms again showing no significant influence (all P > 0.05), underscoring the robustness of abundance-based signals across cohorts.

I do think it is appropriate to highlight those smooth terms which are extremely significant (p<2e-16) according to this test.

We found 1341 of 4404 that passed QC in our own study (30.4%) were nominally associated with ethnicity (p<0.05), which represented a highly significant (p<2×10 −16 ) enrichment.

AHRR also showed highly significant hypomethylation ( p < 2 × 10 −16 ) ( Figure 4 I), confirming its consistent pattern of methylation loss across both lung cancer subtypes.

We repeated linear regression analyses for the top significant CpGs in RUNX1 (cg12477880) and FLI1 (cg17239923), genes that are known regulators of hematopoiesis, adjusting for deconvoluted blood cell proportions instead of ReFACTor components (see “Methods”), and the associations with DS remained highly significant (both P < 2.0 × 10 −16 ).

Again, rs708727 was found to be a highly significant ( p < 2e−16) covariant of all probes, while rs960603 is not.

The microbial alpha diversity was significantly increased in gastric tumor compared with non-tumor tissues in three datasets P1, P3, and P4, with the exception of P2 which showed an opposite trend ( Figure S3A ), while the remaining datasets showed non-significant differences, resulting in a highly significant global Analysis of Variance (ANOVA; F -statistics: P < 2E−16) but a non-significant overall pairwise comparison ( P = 0.19).

gondii /THP-1 conditioned media resulted in a highly significant (P = 2x10 -16 ) increase in H . hammondi vacuole size ( Fig 7C ).

Statistical analysis via disk diffusion assays revealed highly significant differences in inhibition zone diameters among microorganisms ( p < 2 × 10 −16 ).

All other pairwise comparisons were highly significant ( p < 2e-16 ).

We observed a highly significant difference from the expected equal distribution (χ2 = 83.143, df = 3, p < 2 × 10−16).

After including non-LA ω-6 PUFA in the model, the association of the FADS with LDL-c remains highly significant ( p < 2.0 × 10 −16 ).

A resampling approach showed a highly significant association between methylation profiles in blood at baseline and future disease status (P=2.0×10 −16 ).

To determine the significance of the results, we fit three one-way analysis of variance (ANOVA) models comparing ssGSEA scores of CD4, CD8, and macrophage cell type markers, which were all highly significant ( p = 2 × 10 − 16 , p = 6.28 × 10 − 15 and p = 2 × 10 − 16 , respectively).

The genotype×broomrape race interaction was highly significant for TotAD ( F =3.17, P =2e-16), HeaAD ( F =2.96, P =2e-16), and NecAD ( F =3.63, P <2e-16) ( Supplementary Table S3 ).

t-PGCS DNMs and likely post-zygotic DNMs) we first fit a simple Poisson regression model that calculated the effect of paternal age on total autosomal DNM counts in the R statistical language (v3.5.1) as follows: glm(autosomal_dnms ~ dad_age, family = poisson(link='identity’)) This model returned a highly significant effect of paternal age on total DNM counts (1.72 DNMs per year of paternal age, p<2e-16), but was agnostic to the family from which each third-generation individual was ‘sampled.’ Importantly, a number of third-generation individuals in the CEPH/Utah cohort share grandparents, and may therefore be considered members of the same family, despite having unique second-generation parents ( Figure 3—figure supplement 1 ).

8(B) ] by the end of D6, which was highly significant (χ 2 = 70.3, df = 1, P = 2.0E −16 , n = 32).

For these comparisons, the two-sample proportion test is highly significant, p-value < 2 × 10 −16 ; Supplementary Table S2 .

One interesting example is glycan 5402, which had a small positive correlation (PPMCC 0.28) with A1AT’s serum concentration when present at site A1AT site 70 ( P = 0.006) but had a strong highly significant negative correlation (PPMCC -0.81) with the serum concentration of A1AT when present at A1AT site 271 ( P < 2E−16) (Fig. 2 F).

Interestingly, in all tumors FOXP3 expression is highly significant, positively associated to GZMB expression levels ( p -value = 2.0E-16) Adaptive immune response strongly depends on the B cell response.