Excerpts

This targeting is highly significant as compared to the targeted human proteome counterpart (exact Fisher test, p value <2,2×10 −16 ).

Our results demonstrate that subtype indicators are highly significant in predicting survival ( p -value < 2.2 × 10 −16 ).

The results indicated highly significant Pearson correlation coefficients of −0.82, −0.68, −0.78, and − 0.71, respectively, with P -values < 2.2e-16 ( Fig. 3B-E ).

The Mann–Kendall trend test showed no time-dependent trend in the publication time of articles ( P =0.4654) but did reveal an increasing trend between the citation density and time ( P =2.2E-16; Fig. 3 ).

ponticus worker (average of 0.00186, range from 0.0002 to 0.0024) versus all other individuals which have very close to zero γ values (average of 1.86 × 10 −6 , range from 6.598 × 10 −7 to 6.461 × 10 −6 ), with a highly significant difference (two-sided Wilcoxon rank-sum test, P < 2.2 × 10 −16 ).

When miRNA expression levels were averaged for tissue type across animals within the groups, Spearman’s rank correlations between PBMCs and the brain regions are all highly significant ( r s = 0.47–0.57; P < 2.2 × 10 –16 ), although pairwise correlations among the brain regions are markedly stronger ( r s = 0.86–0.99).

The overlap was highly significant, with 30% (1095/3647) of SEM CpGs found to be among NRBC-associated CpGs ( p < 2.2E−16).

Notably, the relaxed (R) state showed highly significant differences ( p < 2.2 × 10 −16 ) from all other emotional states across all features.

magna SGR and was highly significant ( p < 2.2 × 10 −16 ; see Table 2 for additional information).

The rescue of genes found differentially expressed in ∆ Firre CLPs by a Firre transgene produced a highly significant result ( P = 2.2e-16, Fisher exact test); however, we note that the widespread changes in gene expression observed in the CLPs from animals only expressing transgenic Firre RNA could also formally contribute to this effect.

0.00276, Fisher's exact test p-value = 1.34e-05), there is a highly significant excess of sites supporting the species topology (0.00229 vs. 0.00210, Fisher's exact test p-value < 2.2e-16) and deficit of sites in these regions supporting ILS topologies (0.00042 vs. 0.00066, Fisher's exact test p-value < 2.2e-16, Fig 2B and 2C ), which suggests that the observed reduction of ILS is not the result of a lower mutation rate.

Strikingly, ten of these hypermethylated AIMS-Seq amplicons were located in the gene promoter region of the downregulated genes ( Aqp4 , Axin2 , Atad5 , Brca1 , Fads1 , Lgr5 , Phgdh , Slc1a2 , Slit2 , St3gal3 ) belonging to the expression signature of the intestinal stem cell [ 7 ], which represents a highly significant enrichment (Fisher exact test, p value <2.2e-16).

This comparison also revealed highly significant, albeit slightly weaker correlations (Pearson correlation 0.73; P <2.2e-16; Figure S11 ) – similar to the results we obtained for chromosome 1 CNVs.

Withdrawal of glutamine reduced global translation in both conditions, but there was a highly significant increase in translation driven by MYC compared to that seen in cells transduced with the pM6P vector in the absence of glutamine ( P value = 2.2 × 10 −16 ).

The difference between the nuclear area of cells from infected and uninfected plants was highly significant (based on the Brown–Mood median test, p = 2.2e-16), and the nuclear area of cells from P. brassicae -infected plants was 2.8 times bigger based on the median size.

We observed a highly significant gain of methylation with age at the locus in the LBC cohort, validating our approach (Fig. 1 a, T-test, p < 2.2 × 10 −16 ).

There was, however, a highly significant correlation between change in TE score and GC content (Pearson’s correlation value of −0.1337, p-value<2.2e −16 ) ( Figure 1I ).

We find a highly significant departure from the expectation that the mean blunting score is equal to zero (two-tailed one-sample t test P < 2.2 × 10 −16 ), demonstrating that deletion of ENH5 results in a transcriptome-wide dampening of the response to sustained hypoxia ( Fig. 3E ).

Clustering of MBM regarding β-values of each CpG area revealed a highly significant ( p < 2.2e−16) separation of BRAF mut and BRAF wt /NRAS mut tumors (Fig. 8a , right panel).

Comparing the probeset response slopes predicted by our model with the slopes obtained from the Affymetrix tissue panel data, we detected a highly significant correlation both in mouse and human (Pearson correlation coefficient in mouse 0.528, P << 2.2 × 10 −16 , and in human 0.468, P << 2.2 × 10 −16 ).

The overlap was highly significant (Fisher’s exact test P value <2.2 × 10 −16 ).

As a result, we found a highly significant positive relationship between visual bleaching scores on Day 0 and Day 7 post-stress ( Fig 3A and S2 Table , linear mixed effects model, p < 2.2e -16 , marginal R 2 = 0.863, df = 44), such that VBS at Day 0 post-stress was highly predictive of VBS throughout the following seven-day period.

We observed a very weak but highly significant correlation in synonymous heterozygosity between species (Pearson’s r = 0.14, p<2.2e-16), consistent with some degree of conservation for genic parameters of mutation rates and/or selection at Drosophila synonymous sites [ 58 , 70 – 74 ].

Indeed, this overestimation was highly significant (1-tailed t- test, t = 9.66, df = 557.16, p < 2.2 –16 ).

This test revealed a highly significant difference in the overall distribution ( X-squared = 81.204,df = 4, P -value < 2.2e-16 ).