Excerpts

Compared to the expectation under random assignment, this is an over-representation in this category of 40% in yeast and 29% in human, which is modest, but because of the large numbers, highly significant (both p<1e-10).

At least one error affecting a whole chromosome was detected for total of 15,842 (62.1%) of the remaining 25,497 blastomeres as compared to 7,623 (44.3%) of 17,219 TE biopsies, a highly significant difference [ χ 2 (1, N = 42,716) = 1323.8, P < 1 × 10 −10 ].

This represented a highly significant overall decline in the inheritance of BMI with increasing exercise (P<10 −10 ).

Post-hoc t-tests showed a highly significant difference between FM (mean number of trials = 37.12; s.d. = 7.3) and FH (mean number of trials = 5.5; s.d. = 2.37) (t 16 = 14.94, P <10 −10 ).

Figure 1 C shows across 9,320 gene promoters, RNA Pol II pauses at very similar locations among the five individuals; pairwise correlations ( Figure 1 D) are highly significant (p < 10 −10 ).

On the basis of counting statistics (binomial distribution), this difference is highly significant ( p << 10 −10 ).

There was a highly significant agreement (Pearson's R = 0.41, P < 10 −10 ) between the model prediction and the measured changes in protein levels, with the model also quantitatively matching the proportional relationship (gradient of slope = 0.75) (Fig 6 F).

This revealed four regions with highly significant differentiation ( P < 10 −10 after Bonferroni correction, per SNP χ 2 test (d.f. = 1); Supplementary Fig. 1 ).

Still, these correlation values were highly significant, also driven however by the large number of observations (p < 10 -10 ).

1 B, were 0.45 ± 0.13 (standard deviation) and 0.92 ± 0.07, respectively; the difference was highly significant (P < 10 −10 , t test for paired measurements).

5 , 6 , p < 0.05, false discovery rate (FDR) corrected], and in nine such comparisons, results were highly significant (Figs. 5 , 6 , p < 10 −10 , FDR corrected); see Supplementary Data 5 for AUC histogram bin data (bootstrapped resamples).

Average Movement Duration, Velocity and Distance The average duration of movement events is the most distinctive feature of thrips behavior between these two genotypes with highly significant scores of P = 10 −10 in the best experiment 3 with 39 samples ( Tables 1 , 2 ).

Despite the small size of the validation set (412 d ( P , T ) and 694 d ( P , P ) interactions), representing only 1% of the possible secondary regulatory interactions, PhosTF predicted 40% of the known d ( P , T ) and 28% of known d ( P , P ) interactions, which was highly significant ( p < 10 −10 ) when compared to the rate of predictions overall (20% and 18% respectively).

Across multiple Glomeromycetes species, chi-square tests of double-base substitution bias gave highly significant P value (all p < 10 − 10 ), and TT>AA, TA>AT, and AT>TA repeatedly showed the strongest positive standardized residuals within the TT, TA, and AT categories, respectively ( Supplementary Tables S4 , available as supplementary material at Bioinformatics Advances online; Supplementary Methods , secti

There is a good visual agreement between the logos of the simulations and uniref90, and the r values vary between 0.63 and 0.77 (see Table 2 ), which is highly significant (p < 10 -10 ).

Moreover, assessing, collectively, only those ( H +)-carrying CEHs that had a single representation in the WTCCC, the disease association is still highly significant and of similar magnitude to other ( H +)-carrying CEHs (i.e., OR = 3.0; CI = 2.7 − 3.4; p < 10 −10 ).

However, gene ontology enrichment analysis revealed a highly significant enrichment of glycolysis-associated proteins ( P < 10 10 ), with downregulation of the entire glycolytic pathway, and conversely an upregulation of AMP-activated protein kinase signaling– and autophagy-associated proteins, promoting catabolic pathways to generate more ATP.

This advantage of the simple model was highly significant across vertices ( t (23,807) = 34.54, p < 10 −10 ).

We find a highly significant improvement in model performance (R 2 of 0.035 vs. 0.14, p < 10 −10 ). 3.2.

We found 1060 upregulated genes in Wit49 and 396 in 17.94, with a highly significant overlap of 212 genes between the two cell-lines ( p < 10 −10 ) ( Figure 3 A).

Several proteins were upregulated in the CBD-treated group, including large ribosomal subunit proteins (uL30/Rpl7, uL1/Rpl10a, uL2/Rpl8), molecular chaperones (Hsp90b1, Hspe1, Hspd1), calumenin (Calu), and macrophage migration inhibitory factor (Mif), all with highly significant changes (p < 10 −10 , FDR <10 −9 ).

When plotting the solubility and disorder scores at neutral pH (pH = 7.0), a highly significant linear correlation was observed between these two variables (R 2 = 0.90, p < 1 −10 ) ( Figure 3 ), suggesting that solubility and disorder are intimately ligated in this dataset.

Indeed, we observed a highly significant enrichment of H3K9 methylation at 49 known 26G loci ( Vasale et al. 2010 ) compared to 100 random genes ( P -value < 1 × 10 −10 ) ( Fig. 5C ).

The difference between the fraction of paused and non-paused genes containing GrIn1 elements was highly significant (χ 2 = 82; P < 10 −10 ).

The agreement between the datasets/methods is moderate (de Lichtenberg et al , 2005a ), (Supplementary Information, Fig 24), but nevertheless highly significant ( P < 10 −10 in all pair wise Fisher tests).