Excerpts

Additionally, after a Bonferroni correction for the testing of 8 traits, we also identified highly significant QTNs with P ≤ 6.25 × 10 –9 [i.e., (5 × 10 –8 )/8].

Fisher’s Exact Test revealed a highly significant p-value (p-value = 6.52e-09), indicating a statistically significant difference between the observed DEG overlap and random overlap.

This large region also includes the highly significant tag SNP (ALGA0079529, p -value = 6.53 × 10 −09 ) that is within the STOX1 gene.

For PET imaging, increasing MTV between T0 and T2 was highly significant for worse OS and PFS ( p = 6.678 × 10 −9 and p = 6.973 × 10 −6 ).

Additionally, the Fisher’s LSD test showed highly significant differences within genotypes for HCS (p = 6.7e -9 ), DV85 (p = 2e -9 ), and NDCMP49 (p = 4.6e -10 ;).

Statin free individuals were further stratified on sex ( Figure 1 , right-hand panel, squares and diamonds), revealing a highly significant effect in females; at best, the TC-PGS explained 19.0% of the variance in PREVENT-AD ( p = 6.70 × 10 −9 , p -value cut-off 1 × 10 −10 ) and 13.1% of the variance in ADNI ( p = 9.6 × 10 −4 , p -value cut-off 1 × 10 −7 ).

Chi-square test showed that the association of number of exposures to the risk of alloimmunization was highly significant ( P = 6.843e-9).

The most highly significant estimate corresponded with the downregulation of PINX1 (z = -5.79, p = 6.89E-9), a potent inhibitor of telomerase [ 37 ].

The resulting test of diversifying selection acting on the duplicated Steep1 was highly significant ( P = 6.95E−9).

A highly significant inverse correlation was observed between 8-oxodG level in sperm DNA and sperm concentration ( r = −0.52; p = 0.000000007) ( Figure 2A ), for the whole study population.

Classification Results In logistic regression analysis using the 150 best signal features, the difference in MCG findings between STEMI and control patients was statistically highly significant ( p = 0.000000007) ( Figure 4 ).

We found a highly significant increased frequency of mutations in familial cases compared to nonfamilial cases ( P = 7.1 × 10 −9 ).

In addition, module membership (MM) of the individual genetic features in the Green module demonstrated a highly significant correlation with their respective gene significances (GS) for the cancer trait ( r = 0.75, P = 7.1 × 10 −9 , Figure 3C ).

This difference from 90° was highly significant (one-sided p = 7.5 × 10 −9 , Wilcoxon signed-rank test vs. 90°, Figure 2 J), revealing that, as in the locust, odor ON and OFF responses in mouse OB glomeruli are inverted relative to each other.

The effect was strong and highly significant (Mann–Whitney U test p value = 7.6 × 10 −9 ).

The negative correlations between the coselection scores and SPL were highly significant in all four groups ( P = 7.8 x 10 − 9 , 2.9 x 10 − 9 , 2.9 x 10 − 9 , and 6.7 x 10 − 12 for YRI, EAS, CEU, and combined, respectively).

Eleven of the 21 genes were also found in a list 180 genes compiled from published PCa outcome signatures (Additional file 2 ), which is a highly significant enrichment ( P -value = 7.9e-9, Fisher’s exact test), especially when considering that no gene information was used to infer our signature.

In the subsequent age group of 4–6 years ( n = 80), the mean ratio (1.22 ± 1.58) was slightly below the meta-mean (1.54), showing marginal statistical significance in parametric testing ( t -test, p = 0.074), yet highly significant differences emerged with non-parametric methods (Wilcoxon test, p = 8.03 × 10 −9 ; Binomial test, p = 3.16 × 10 −12 ), albeit with a relatively smaller negative effect size (Cohen’s d = −0.20).

Our results show a clear trend of increased total lipid levels with the progression of pregnancy (R 2 = 0.78, FDR-adjusted p -value = 8.05 × 10 −9 , Figure 1 ).

In GENRA/SLESS one further haplotype was observed, which was not present in Europeans [encoded by HLA-DRB1 *14:04; MAF = 0.005; OR = 0.96]. Omnibus tests showed highly significant associations for amino acid positions 11 and 13 in HLA-DRβ1 ( P = 8.1 × 10 − 9 , P = 7.8 × 10 − 9 , respectively) and case–control status in GENRA/SLESS, but not positions 74 ( P = 0.017) and 71 ( P = 0.20).

The effect of temperature was highly significant in an ANOVA ( P = 8.16E−9), which was corrected for gene variation while the bacteria effect was barely higher than the acceptance level of α = 0.05, due to the smaller effect size ( P = 0.0557).

The overall model was highly significant ( p = 8.18E-09), indicating significant factor effects on the number of axial buds growing from the rootstock.

Notably, although we identified WMG-2 in the predominantly MNA cluster 3, Kaplan-Meier analysis of low-risk tumours in the SEQC dataset (n=322) with WMG-2 demonstrated a highly significant association of low WMG-2 with poor survival (p=8.2 x 10 -9 ) ( Figure 5 D , right).

These differences were highly significant between sessions (Pearson's χ 2 = 46.2, df = 5, p = 8.21e9).

Among the genes overexpressed in LF, 6 were putatively involved in insecticide resistance which represents a highly significant overrepresentation for these genes ( χ 2 with Yates correction for continuity, χ 2 = 33.21 , P -value = 8.29 e- 09 ).