Barely Significant

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highly significantp = 0.00240.0× alphaqualifiedgold
A 2-way ANOVA on condition and Δf confirmed that the bias showed a significant effect of condition (LFP: F(5,1735) = 31, p∼0; MUA: F(5,615) = 12,p∼0), a non-significant main effect of Δf (LFP: F(3,1735) = 0.99, n.s.; MUA: F(3,615) = 0.95, n.s.), but a highly significant interaction between condition and Δf (LFP: F(15,1735) = 4.9, p∼0; MUA: F(15,615) = 2.38, p = 0.0024).
marginally significantP < 0.00240.0× alphagold
The results demonstrated that MX2 displayed the most significant eQTL with rs398206 ( P = 6.6e−15; linear regression), while none of the other genes in the TAD displayed even a marginally significant eQTL after adjusting for multiple testing (Bonferroni-corrected cutoff at P < 0.0024 for 21 genes; Supplementary Table 9 ).
moderately significantp ≤ 2.4 × 10 −30.0× alphaqualifiedgold
The scenarios are presented below: Markers that were 25 kb of a moderately significant DE genes ( p ≤ 2.4 × 10 −3 ); Markers that were 100 kb of a moderately significant DE genes ( p ≤ 2.4 × 10 −3 ); Markers that were 25 kb of a highly significant DE genes ( p ≤ 1.0 × 10 −4 ); Markers that were 100 kb of a highly significant DE genes ( p ≤ 1.0 × 10 −4 ); For scenarios i, ii, iii, and iv, the number of markers used to construct G DE were 864, 2,317, 354, and 941.
nominally significantp -value = 2.4E−030.0× alphagold
Conditioning on this common variant rs3817928, the joint test of gene-by-current-smoking analysis for GPR126 remained nominally significant in the discovery ( p -value = 2.4E−03) and genome-wide significant in the replication studies ( p -value = 3.9E−09 in UK BiLEVE and p -value = 9.6E−17 in UK Biobank, Table 3 ).
showed a trendP =0.002440.0× alpha
The mRNA and protein levels of IFN-γ showed a trend similar to that of TNF-α (DRG: day 8, P =0.00244, day 14, P =0.00029, SC: day 8, P =0.00049, day 14, P =0.00096, HIP: day 8, P =0.00424, day 14, P =0.00288, Fig. 1 c; DRG: day 8, P =0.053, day 14, P =0.0021, SC: day 8, P =0.016, day 14, P =0.0060, HIP: day 8, P =0.023, day 14, P =0.078, Fig. 1 e).
highly significantP < 0.00250.0× alphaqualifiedgold
To determine whether these highly significant microbiome signals ( P < 0.0025) could be used to distinguish children with ASD from their age-matched and sex-matched control counterparts, we trained random forest classifiers on train/validation/test splits of data derived from 16S-targeted sequencing and SMS–whole-genome sequencing of microbial communities.