Excerpts

Although the GO annotation term includes both positive and negative regulators of Wnt signaling, the pathway “negative regulation of canonical Wnt signaling” is also nominally significant for the biased downregulation of freshwater alleles (7/7 genes, Fisher's exact test, P = 0.0048), suggestive of the biased Wnt inhibition in marine fish ( figs. 3 D and E ).

This was a highly significant difference ( p = 0.0048, Fisher’s exact test) in mortality between the Venus control and the combined vaccine groups.

To assess the statistical significance of this finding, we performed a simulation with a null distribution of 10,000 trials of 129 genes chosen at random and found the overlap to be highly significant ( P = 0.0048).

Interestingly in the eRA synovium from PEAC study, the correlations between baseline GZM A and DAS28-ESR were positive and highly significant ( r =0.31, p=0.0048) ( Fig. 3A ), GZM B and DAS28-ESR ( r =0.29, p=0.0077) ( Fig. 3B ), GZM K and DAS28-ESR ( r =0.33, p=0.0031) ( Fig. 3C ), GZM H and DAS28-ESR ( r =0.27, p=0.015) ( Fig. 3D ), GZM M and DAS28-ESR ( r =0.33, p=0.0023) ( Fig. 3E ), PRF-1 and DAS28-ESR ( r =0.39, p=0.00033) ( Fig. 3F ), SRGN , DAS28-ESR ( r =0.31, p=0.054) ( Fig. 3G ) and CD27 ( r =0.30, p=0.007) ( Fig. 3H ).

Differences in vimentin expression between the clones were highly significant (p < 0.0048; Kruskal Wallis statistics = 14.94; df = 4).

Fifty percent of animals treated with 5 μg of VLP survived, but inclusion of either 10 or 1 μg of polyICLC increased survival to 100%, which was also a highly significant increase (p = 0.0048) ( Figure 1C ).

Nominally significant associations between eyeAge and both COPD (p-value = 0.0048) and myocardial infarction (p-value = 0.049) were observed ( Supplementary file 3 ).

Importantly, a highly significant, inverse relationship between the plasma concentration of Fgl2 and both the frequency ( P = 0.0048) and absolute number ( P = 0.0044) of total CD8 + T cells was observed in patients with COVID-19 ( Figure 4B ) that was not observed in healthy controls ( P = 0.9; Figure 4B ).

Upon statistical normalization of the TG levels using logarithmic transformation, due to the wide baseline range (Figure 3A ), a highly significant decrease was observed following administration of aleglitazar (Figure 3B ; P = 0.0048).

Likewise, the increase of NfL within each group from baseline to 90 months was also highly significant using NfL z‐scores (AD: p = 4.8 × 10 −3 , controls: p = 3.6 × 10 −11 ).

More importantly, the rs182089527 distribution also showed a trend of difference between kidney cyst patients and healthy controls for both the allele (Fisher’s exact test, p = 0.0048, adjusted p = 0.067) and genotype (Fisher’s exact test, p = 0.0049, adjusted p = 0.068) comparisons.

Strikingly, we find that DS subjects exhibit a highly significant age acceleration effect in three independent data sets ( P = 0.0048, P = 5.5×10 -7 , P = 0.00056 Fig. 1e – g ) involving blood and brain tissue.

The left hippocampus of patients also resulted smaller (3202.9, SD 2795.9) than that of controls (6137.5, SD 3079.9); this difference resulted highly significant ( F = 9.052; p = 0.0048; lambda = 8.31; power = 0.82).

Of the remaining three genes, MORC1 and CSRNP3 showed a nominally significant association with MDD ( P =0.00483 and 0.03139, respectively).

As a less conservative estimate, directly sampling from the universe of SNPs and estimating the probability of observing at most two derived SNPs and a mean AF as large as the empirical variants of interest produced a highly significant P -value = 0.00487 ( supplementary fig.

Additionally, the SHOC1 gene showed a trend for association under a gene-wise framework ( P = 4.88E−03) ( Table 2 and Supplementary Table S9 ).

leprae growth did not continue past the 6 months peak in the NOS2−/− but showed a trend toward improved clearance at 12 months ( p = 0.0049).

When comparing Group 1 (5, 7.5, and 10 mm; mean = -7.21 ± 3.74) and Group 2 (12.5, 15, 20, and 25 mm; mean = -0.23 ± 1.13), a highly significant difference was found ( p-value = 0.0049).

This difference was highly significant (P = 0.0049).

Analysis of semantic enrichment from other database such as Swissprot PIR keywords and Interpro did provide highly significant enrichment of terms such as 'metal-binding' (67 genes, P = 0.0049), 'metalloprotein' (12 genes, P = 2 × 10 -5 ), 'zinc finger, NHR/GATA-type' (6 genes, P = 8.8 × 10 -4 ), 'iron' (13 genes, P = 0.0023), and 'cytochrome P450' (7 genes, P = 0.0019), whilst weaker associations with terms included 'calcium-binding EF-hand' (11 genes, P = 0.015) and 'calcium' (22 genes, P = 0.029).

The correlation between the fold changes of PCNA and the Z scores of V$NFKAPPAB65_01 showed a modest significance (r 2 = 0.0616; p < 0.0049; q < 0.04) (Figure 2D ).

These analyses show significant or borderline significant enrichment of several pathways related to hypertension in plasma, namely steroid hormone biosynthesis (combined p value = 0.0049), primary bile acid biosynthesis (combined p value = 0.063), and arachidonic acid metabolism (combined p value = 0.084) for plasma and purine metabolism in urine (combined p value = 0.0071).

This association was highly significant both in patients who underwent optimal (HR = 0.74, P = 0.0049) or suboptimal surgery (HR = 0.63, P = 5.7e‐05).

The CHX-treated specimens showed a highly significant reduction ( P < 0.0049) in the number of microbes after instrumentation and irrigation.

Consistent with the stated hypothesis, people with proportionally lower cNFL concentration had a marginally significant increase in brain atrophy measured by semiquantitative outcome ( P = 0.0049) and BPFr ( P = 0.053) in the training cohort.