Excerpts

Sidak’s multiple comparison test revealed a highly significant difference between the neuronal cross-sectional area of STN neurons in control rats and those ipsilateral to the lesion at 5 months (P = 0.0046), and a more moderate difference at 1 month post-lesion (P = 0.0443), suggesting that the cross-sectional area of STN neurons is reduced between 1- and 5-months post-lesion.

In the comparison of the mRNAsi among clinical phenotypes of EC, we found that the mRNAsi score was significantly higher in patients with stage IV disease, with an increasing trend from stage I to stage IV (stage I < stage II < stage III < stage IV) ( p = 0.0046, Kruskal-Wallis test) ( Figure 1(c) ), and the pathological grade presented the same trend (grade 1 (G1) < grade 2 (G2) < grade 3 (G3) < high-grade) ( p < 0.0001, Kruskal-Wallis test) ( Figure 1(d) ).

Notably, PTE-Tw80@PDs exhibited superior protective efficacy compared to TiO 2 , as evidenced by a highly significant difference ( p = 0.0046).

Two (MET, PDGFRA) out of the three targets (MET, PDGFRA and PYK2) were experimentally validated as sensitizing targets of AKI-1 in the pancreatic cancer, representing a highly significant enrichment (hypergeometric test, p = 0.0046) ( Figure S4 in [55] ).

However, the G-G haplotype of IRF6 was nominally significant with NSCL/P ( p = 0.0046) and is worthy of consideration for another independent replication study in the future.

Using the mean values of resistance and compensatory ability for each variety, we found a highly significant negative correlation between resistance and compensatory ability (Pearson’s r = –0.9954, p = 0.0046, d.f. = 2; Figure 7 ).

We had corrected the influence of hypoalbuminemia among critically ill patients for the AG, and a positive trend was also noted ICU mortality ( p = 0.0046; Figure S1A ) and in-hospital mortality ( p = 0.0006; Figure S1B ).

Based on the cluster analysis we identified two main patient clusters: one main cluster that included most patients with increased CRP levels and another including most patients with normal/low CRP levels; this difference was highly significant (Chi Square test, χ 2 = 8.02, p = 0.0046).

Even though the results among medium drinkers were not statistically significant, a significant trend ( P = 0.0046) was observed.

The delay was notably longer for chimera 264 (89 min) than sANTXR2 (77 min), and the difference was highly significant ( p = 0.0046), suggesting increased therapeutic potency of the multivalent particles over monomeric sANTXR2 as an inhibitor of the anthrax toxin.

Among these, only the ATAC-seq regions that were decreasing in accessibility had a nominally significant (p value = 0.00463) less than expected presence for ADHD, and this effect was not present when the regions are extended by either 1 kb or 10 kb.

Again, the effect was highly significant ( r = −0.65, p = 0.0047; Figure 2C , inset).

Similarly, the Iba1 integrated density was reduced by 36.8 percentage points in the cone-shaped group (85.4% ± 10.5%) relative to the bare group (122.2% ± 9.2%), showing a highly significant difference (p = 0.0047).

patients using Fisher’s Z test yielded a highly significant difference ( Z = 2.83; p = 0.0047, two-tailed) [ Note : When using Spearman’s correlations without outlier detection, this pattern remained qualitatively unchanged (controls: ρ = 0.559, p = 0.0103; patients: ρ = −0.339, p = 0.1990)].

The analyses show significant and marginally significant associations of this allele with HDL-C ( β = -3.8, p = 4.7×10 −3 ) and TG ( β = 6.6, p = 3.3×10 −3 ) in ARIC and BMI ( β = -3.4, p = 5.7×10 −2 ) in the FHS original cohort ( S1 Table ).

Included patients showed a trend of worse EFS and OS post-ASCT (EFS: HR = 3.21, 95% CI 1.43–7.21, p = 0.0047; OS: HR = 2.88, 95% CI 0.58–14.4, p = 0.20), possibly owing to the fact that the ASCT was given mainly to newly diagnosed patients as consolidation prior to relapse, and relapse is associated with poorer prognosis.

Analysis of the subarachnoid space at E16.5 in Rev3l +/ − mice revealed a highly significant increase in subarachnoid volume ( t -test, P value=0.0047; Fig. 3a ).

Notably, all GBA-NMC individuals who were identified as prodromal PD, based on the MDS research criteria 16 , had the abundance of coherent PD-enriched species above the median, a highly significant bias ( χ 2 test, P = 4.7 × 10 −3 ), and four were at the very top of the distribution (Fig. 3 ; P = 5.7 × 10 −4 ).

Interestingly, across all cell subtypes examined, women showed a trend (p=0.0047, Chi-square) for higher CS activity (range: 4–29%, g=0.20–1.52, Figure 5a ) and higher CII activity than men (range: 1–10%, g=0.03–0.56, Figure 5d ).

However, the increase in TEER from cells with TNFα removal was not sufficient enough for a significant difference to the cells without the removal of the cytokine, but was close to being statistically significant (one-way ANOVA: F (2,26) = 6.64, p = 0.0047, n = 7–13; TNFα w/o Recovery: 77.36 ± 11.41%; TNFα w/ Recovery: 115.88 ± 15.65%; p = 0.076).

However, for beat sequence lengths 5000 and higher, the difference was highly significant (p ≤ 0.0047).

A highly significant moderate negative correlation (r=−0.5183, P=0.0047) was observed for the HIV+ group, demonstrating that as TEAC increases, TBARS concentration decreases.

A highly significant positive correlation was seen between chemerin and total body fat ( r = 0.4492; P = .0047), 2hPGPG ( r = 0.5755; P = .0021), HbA 1c ( r = 0.4187; P = .0058), TGs/HDL-c level ( r = 0.5491; P = .0001), and a partially significant correlation was seen with waist circumference ( r = 0.2863; P = .0733) ( Fig 2 and Supplementary Table S2) [ 20 ].

The interaction of the percentage of section limitation with the diameter of the arterial cannula was highly significant ( p = 0.00478).

Although the GO annotation term includes both positive and negative regulators of Wnt signaling, the pathway “negative regulation of canonical Wnt signaling” is also nominally significant for the biased downregulation of freshwater alleles (7/7 genes, Fisher's exact test, P = 0.0048), suggestive of the biased Wnt inhibition in marine fish ( figs. 3 D and E ).