Excerpts

Furthermore, 394 probesets showed very highly significant correlation ( P < 0.005).

Introduction A non-adjuvanted cysteine peptidase-based vaccine represents a means of alleviating schistosomiasis symptoms and reducing transmission, as it consistently and repeatedly elicits a highly significant ( p < 0.005, p < 0.0001) reduction in challenge Schistosoma mansoni and Schistosoma haematobium burden in mice and hamsters [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ].

The confidence interval (0.22 to 0.77) and minimum heterogeneity (I 2 = 4%) highlight the consistency and reliability of the results, with a highly significant overall effect ( P value = 0.005).

If we include the oxacillin survivors, the differences in viable cell densities for the 5× MIC comparison (gentamicin, oxacillin and vancomycin) were highly significant (F(2,26) = 25.6, p<0.005).

As E3/E3 genotype is considered neutral genotype in our Asian population, E3/E3 genotype is highly significant in prevention of ischemic stroke ( P = 0.005) and E3/E4 genotype has significant association in causing ischemic stroke ( P = 0.011).

As an example, in Figure 7B , we show analyses of the two genes CCNE1 and USH1C , demonstrating a highly significant change in skipping exon 9 or exon 11, respectively ( P values < 0.005).

Our results (Q2Y > 0.5) indicated that this model provided good predictability without overfitting, and this difference was highly significant ( p = 5 × 10 − 3 , permutation test) (supplementary Fig.

The clustering of the pretreated AML patients and HD based on the highly significant DE miRNAs (21 up and 18 down p < 0.005 and 2 FC) showed a high separation between the two groups ( Figure 1 A,B).

A comparison of the effect of HCMV effect in males and females showed a highly significant difference between the sexes with respect to CLO75 IL-6 responses (unadjusted p = 0.005, adjusted p < 0.001) ( Figure 1 B, Table 4 ).

For the LBP group, there was a significant reduction in pain score with treatment from a median of 9 to 6 (Wilcoxan, Z = 2.87, p = 0.0041); however, although quality of life measurement changes were similar to the failed back syndrome cohort and showed a trend to improvement this was not statistically significant (Wilcoxan, p > 0.005).

Median chitotriosidase values showed highly significant commensurate reduction with eliglustat treatment in both cohorts ( P ≤ .005): 24% in non‐splenectomized switch patients and 38% in splenectomized switch patients after 2 years in this real‐world cohort compared to 63% after 4 years in ENCORE. 20 The safety of daily oral eliglustat cannot be assessed in the Registry, because adverse event data and reasons for discontinuing treatment are not captured.

For rs7795011 in IMMP2L, we observed a nominally significant over-transmission of T allele in the Greek population ( p = 0.005, χ 2 = 8.0), which withstands 1,000 permutations test ( p = 0.027).

Differences were considered as “highly significant” in cases with p -values ≤ 0.005, as “significant” with p -values ≤ 0.05, as “borderline significant” with p -values between 0.05 and 0.1, and as “not significant” (n.s.) with p -values ≥ 0.1.

Since the mechanical studies in STAT3-OKO-M mice all yielded highly significant effects (p<0.005), while the studies in STAT3-OKO-BL, despite similar effect sizes, did not achieve the 0.025 threshold, we sought to further confirm our prediction of defects in intrinsic parameters consistent with altered bone quality by determining whether meta-analysis of the combined studies yielded significant effects.

It decreased for both trialanine and amino acids significantly or almost significantly after both 1 and 3 FTC (by 0.20 ± 0.05 ( p = 0.005) and 0.08 ± 0.02 h −1 ( p = 0.103) after 1FTC and by 0.25 ± 0.06 ( p = 0.055) and 0.06 ± 0.01 h −1 ( p = 0.001) after 3FTC, for trialanine and amino acids, respectively).

We observed significantly higher lung asbestos body burden if any of these cell cycle genes were methylated ( P < 0.02), and there was a significant trend of increasing asbestos body counts as the number of methylated cell cycle pathway genes increased from 0 to 1 to >1 ( P < 0.005).

All effects were significant ( P < 0.05 ) and highly significant ( P < 0.005 ) at 100 and 300 mg/kg respectively.

ANOVA comparisons of the first with the last five trials within conditions revealed a highly significant effect for the factor CONDITION (F (1,11) = 9.58, p = 0.005, uncorrected) concerning the variable S amb .

The age, smoking, as well as the levels of BMI, AHI, ODI, MAT, TSA90 and the prevalence of hypertension and COPD exhibited a decreasing trend with the elevated MSpO 2 , except for the levels of LSpO 2 and the prevalence of dyslipidemia, which showed an increasing trend (all P < 0.005).

myristica produced a highly significant (p < 0.005) decrease in living cancer cells (MCF-7) after 72 h of incubation.

Although the amounts of CT released from the two bacteria dropped sharply while compared to that retained in the cell extracts, nevertheless 2.23 fold differences between the CT levels measured in vitro remained extremely significant ( P value <0.005).

Statistical significance values were * p < 0.05 (significant), ** p < 0.01 (moderately significant), *** p < 0.005 (highly significant), and **** p < 0.001 (very highly significant). 3.

The condition × bias interaction was not significant in early adolescence, F (1, 46) = 2.61, p = .113, η p 2 = .05, but was highly significant in late childhood, F (1, 75) = 8.36, p = .005, η p 2 = .10 ( Fig. 2 ).

On the contrary, heart rate showed an increasing trend with walking time reaching a significantly higher maximum rate during placebo, with a difference of 5.4 bpm (2.9–8.7, p < 0.005) compared to oxygen.

There was a highly significant difference ( p < 0.005) between the high and low FeNO groups in the number of recorded coughs in 24 h.