Barely Significant

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highly significantp = 0.0080.2× alphaqualifiedgold
To eliminate possible discrimination due to outliers, a Spearman’s test was performed, confirming a highly significant correlation with β2M ( p = 0.008), plasma cell percentage ( p = 0.035), C-reactive protein ( p = 0.043), and serum calcium levels ( p = 0.038), as shown in Figure 3 A.
nominally significantp = 0.0080.2× alphagold
One rare single-nucleotide polymorphism (SNP), HugotSNP8ms2 (minor allele frequency <0.05), showed nominally significant deviations from HWE in the controls ( p = 0.008) and in the full sample ( p = 0.006) due to an overrepresentation of rare homozygotes, which might be the result of chance or genotyping error.