Excerpts

A χ 2 test comparing the 2 treatments (without collection date as a factor) indicates that the difference in cure rate of 80.8% vs 100% is highly significant, χ 2 = 22.6, n = 222, d.f. = 1., p = 2e–6.

The proportion of infection (clear spots) in 63 microviruses of the collection previously reported ( Van Cauwenberghe et al., 2021 ) showed a significant trend to infect R. etli over R. phaseoli (two-samples t-test p = 2 × 10 −6 ; Figures 2B , C ).

This difference between normal and tumor tissue was highly significant (p-value = 2*10 −6 ).

The analysis revealed a significant effect of sample type ( F = 4.70, p = 0.020) and a highly significant effect of treatment time ( F = 38.65, p = 2.00 × 10 −6 ), indicating that both hydrogel composition and healing time significantly influenced wound recovery.

A single SNP (rs4236644) in SEMA3C reached marginal significance ( p = 2e–6) in a meta-analysis of GWAS for total serum bilirubin levels ( Johnson et al. 2009 ).

GTEx annotation of nominally significant SNVs by genome-wide association study identified enriched expression of genes in multiple tissues including the heart and lung ( P = 2 × 10 −6 and P = 6 × 10 −4 , respectively (Suppl.

The addition of IL-6 and IL-8 to a model of mortality prediction composed of clinical variables was highly significant (LR P = 2 × 10 −6 and 1.5 × 10 −5 , respectively) ( Supplementary Table 4 ).

As noted in Table 3 , rs7130284 does not show compelling evidence for association with Hcy in the AA participants included in our meta-analysis (β= −0.069, p=0.023) but the rs11018628 variant reported in WGHS approached borderline significance (β= −0.14, p=2.0 × 10 −6 ).

In a meta‐analysis including 13 independent samples (total N = 1402), the EII demonstrated validity in assessing degree of personality disturbance, its overall weighted effect size with other measures of psychiatric severity being r = 0.29 and highly significant ( p = 0.000002) (Diener et al., 2011 ).

This correlation was larger than the prespecified threshold of ρ = 0.30 and clearly significant with p < 2×10 -6 (Table 2 and Table 3 ).

Pathway enrichment analysis using MetaCore (pathway analysis software from GeneGo) resulted in a highly significant enrichment of genes encoding proteins involved in cytoskeletal remodeling (P = 2 × 10 −6 ), adhesion (P = 4 × 10 −6 ), metaphase checkpoint (P = 7 × 10 −6 ), and cell cycle regulation (P = 7 × 10 −5 ) pathways.

Moreover, the enrichment in these deficiencies observed in MIS-C patients relative to the individuals included in gnomAD was highly significant ( P = 2 × 10 −6 ).

In all tissues and platforms, we observed highly significant but small positive correlation between differences in gene expression as measured by p -values and CNV size (all p < 2 × 10 −6 and all rho < 0.22).

SNP rs116121322 in LRRC27 showed nominally significant association with POAG in the discovery cohort (OR = 29.85, P = 2E–06).

The difference in differentially expressed mature miRNAs in the 22q11.2 del region that showed nominally significant differences in expression compared with mature miRNAs generated from the remainder of miRNA genes on chromosome 22 is highly significant (Fisher exact test, p = 2E-06).

The functional annotation analysis of Ang II–dependent transcriptome using DAVID database 11 revealed highly significant enrichment for genes associated with blood vessel development ( P < 2 × 10 −6 ), angiogenesis ( P < 7.9 × 10 −6 ), positive regulation of proliferation ( P < 0.002), and several associated signaling pathways, including cytokine–cytokine receptor interactions ( P < 0.0076), transforming growth factor-beta pathway ( P < 0.01), notch signaling ( P < 0.02), and protein kinase activity ( P < 0.025) (Fig. 1 ).

The determined Spearman’s correlation was 0.87 and highly significant ( P = 2 × 10 −6 ), as was the Pearson’s correlation (0.85; P = 4 × 10 −6 ).

Although the sample size was small, this association was highly significant (p=0.000002), warranting further study of variables and associations.

The corresponding rm-ANOVA (3 face conditions×14 ROIs) showed highly significant effects of Face condition (F(2,18) = 30.4, p<0.000002, H-F epsilon = 0.997, p<0.000002), and ROI (F(13,117) = 4.44, H-F epsilon = 0.26, p<0.008), and a significant interaction between these two factors (F(26,234) = 2, p<0.005, H-F epsilon = 0.5, p<0.03).

We found a highly significant effect of compression ( P = 2e-6) with an estimated ABpr/ABpl ratio of 0.99 for the uncompressed embryos ( Supplementary Fig.

Reagents based on CPPs (Proteoducin, Chariot) showed a particularly strong and highly significant (p = 2.03*10 −6 and p = 5.20*10 −7 ) cytosolic distribution after PCI treatment.

Twenty-six SNPs (11 non-synonymous and 14 synonymous) showed statistically significant differences (P<0.05), and two SNPs, in position 1039 and 1041 of cagE , showed a highly significant association with cancer (p-value = 2.07×10 −6 ), and the variant codon was located in the VirB3 homology domain of Agrobacterium .

Mann-Whitney U tests showed that the difference was highly significant ( p = 2.1 × 10 −6 ).

Candidate gene analysis Our Gene Ontology pathway enrichment analysis of the impacted genes within the CNV breakpoints identified “detection of chemical stimulus involved in sensory perception (GO:0050907)” and “nervous system process” (GO:0050877) pathways to be highly significant (FDR P < 2.1 × 10 –6 ) and (FDR P < 9.0 × 10 –3 ) after correction.

The median turnover time using the xTAG GPP assay was 1 day, ranging from 0.5 days to a maximum of 2 days except one sample that was lost for several days due to a mail transportation error, whilst the median turnover time for the classical diagnostic algorithm was 3 days (Figure 1 ), which was highly significant with a p-value of p = 0.0000021 resulting from the one-sided T-test for paired samples and a p-value of p = 0.0000042 for the two-sided T-test.