There were two SNPs in the serum IgG analysis, one SNP in the total protein analysis, four SNPs in the globulin analysis, four SNPs in the ZST analysis, one SNP in the specific gravity analysis and three SNPs in the crude illness analysis, which approached significance ( P < 5 × 10 −5 ) (Table 3 ).
In particular, contrary to males, mutant females showed highly significant upregulation of Neuropeptide-like precursor 4 ( nplp4 ) and target of brain insulin ( tobi ) genes ( p = 5 × 10 −5 ).
When the same analysis was run three times, comparing the intention-offloading/nonoffloading task with the other tasks one by one, the intention-offloading/nonoffloading predictor was always highly significant, t (990) > 4.0, p < .00005, but none of the other three was, t (990) < 1.35, p > .17.
This perfect association between hot-spot S2 activity and the presence of S9.1G is highly significant ( P = 0.00005, or 0.0012 after Bonferroni correction for additional markers tested across this region).
We identified highly significant correlation differences between incident CAD cases and controls ( p < 5 × 10 –5 ); eGFR correlated more strongly with 3-hydroxyisobutyrate ( r case-to-control = 0.29), citrate ( r case-to-control = 0.42), and glycine ( r case-to-control = 0.35), while 4-deoxyerythronic acid correlated less strongly with triglycerides ( r case-to-control = −0.35), and hypoxanthine with creatinine ( r case-to-control = −0.30) in individuals with incident CAD.
Of note, eleven of the 16 novel GWS loci exhibited consistent genome-wide marginal significance ( P < 5 × 10 −5 ) between ADHD and MDD.
A comparison of those relations is presented in Table 3 . In single-factor analysis of variance (ANOVA) of polyp diameter in subgroups created with reference to PTEN protein expression, only highly significant differences ( p = 0.00005) were observed.
A total of 1,313 SNPs demonstrated borderline significance ( P < 5*10 −5 ).
We then plotted the observed responses to random textures against the predicted responses, the resulting correlation was positive and highly significant ( r = 0.75, P < 0.00005; Fig. 6 B ).
Using a highly significant P value cutoff ( P < 0.00005), we identified 12 proteins that exhibit differential expression between these OA subsets (Figure 3 ).
In addition, to mitigate potential impacts of small expected counts (e.g., expected values < 5 for TPS-c) on the chi-square approximation, a permutation test (20,000 permutations) was performed and also yielded a highly significant result ( p ≈ 5.0 × 10 −5 ), further supporting that the distribution of core/non-core status varies significantly among subfamilies.
The difference between the performance of two group in OSPE was highly significant ( P < 0.00005).
A highly significant ( p value < 0.00005) likelihood ratio test compared to a standard logistic model supported that the mixed-effects model was better fit for our data.
The correlation between duration of illness and grey matter volume across all networks (uncorrected for TIV and age) showed a highly significant correlation (r = −0.37, p < 0.00005) which was no longer significant after correcting for age and TIV (r = 0.06, p = 0.56).
BALB/c mice vaccinated with 20 μg of SLA plus 50 μg of CpG ODN showed a highly significant (P<5×10 −5 ) reduction in swelling compared to SLA-vaccinated mice and enhanced survival compared to unvaccinated mice.
When exposing 104C1 cells that acquire a fibroblast morphology to increasing concentrations of KDC203, we observed highly significant ( p <0.00005) dose-dependent reductions in PrP C levels ( Fig 2A ).
A recent GWA meta-analysis in Crohn's disease identified 74 independent SNPs as nominally significant ( p <5×10 −5 ) [24] .
The blocking test showed that the pre-treatment of SK-RC-52 renal carcinoma cells with a large excess of unlabeled Ec1 resulted in a highly significant (P<0.00005) reduction in binding for both radiolabeled DARPins ( Fig. 1 ).
There was such increases of 4.4 dB for each of the groups Education , Other and Music , and they were highly significant (p<0.00005, Tukey's HSD).
From this meta-analysis, we ranked the SNPs according to their p -values and selected all the nominally significant SNPs with p -values < 5 × 10 −5 .
There was a highly significant difference between the MODY group and the control group ( P < 0.00005) and between the MODY and type 2 diabetic groups ( P = 0.003).
Across the significant surprise effects, this yielded a highly significant positive correlation (r = 0.75, p < 0.00005; Fig. 2C ).
The statistical data analysis showed that the length of inpatient treatment affects the outcome of the treatment and that the difference is statistically highly significant (p < 0.00005).
However, a number of methylation probes were nominally significant in each analysis ( p < 5 × 10 −5 , detailed in the Supplementary Information ).
Treatment with clopidogrel was found to confer a risk reduction of 20% on the composite endpoint, at a highly significant P = 0.00005.