Excerpts

In contrast, the noncancer group exhibited lower methylation rates, showing a highly significant statistical difference ( p < 0.00005, Figure 2 A, EXdata 2.

While there was no significant effect of blindsight status (positive or negative; F = 2.6, p = 0.13), there was a highly significant effect of lesion side (ipsilateral or contralateral; F = 35.7; p < 0.00005) and interaction, suggesting a differential effect of the lesion in the two patient groups (F = 5.1; p = 0.04).

Moreover, 138 and 176 SNPs were found to have suggestive (moderately significant) association with RFI1 and RFI2 at p < 5 × 10 -5 , of which 124 SNPs have been found to be associated with both traits.

When the same analysis was run three times, comparing the intention-offloading/nonoffloading task with the other tasks one by one, the intention-offloading/nonoffloading predictor was always highly significant, t (990) > 4.0, p < .00005, but none of the other three was, t (990) < 1.35, p > .17.

Especially, apparent is the highly significant decrease for the mean head‐directional firing rate ( Z 65 = −4.053, P = 5.1e‐05) and its loss in correlation between sessions (Fig. 4 f).

We observed highly significant associations between CD40 expression and the rs4810485 genotype in all B cell subsets (patients: P ≤ 5.10 × 10 −5 , controls P ≤ 4.09 × 10 −6 ), with each copy of the multiple sclerosis risk allele rs4810485*T corresponding to lower CD40 cell surface expression levels ( Figs 1 and 2 ).

Of note, BABAM1 is the most highly significant CNV associated locus following full statistical correction of population stratification (p = 5.16×10 −5 ).

The ANOVA detected a highly significant ( F (1,66) = 18.73 , p = 5.2 e – 05) interaction between the carrier factor and the sonicated LGN side (left or right LGN).

These genes showed an extremely significant lower level of nucleotide diversity and Tajima’s D values ( P = 5.22E-05 and 1.23E-30, respectively, Mann–Whitney U test) compared with other genes in the genome ( fig. 1 A ), suggesting a potential selection effects on the divergence observed here.

Additionally, a locus on chromosome 14, within a cluster of SNPs showed a trend toward significance (p = 5.24E-05).

pruinosus population, the overall results of the proportion of individuals (pc) showed a highly significant treatment effect (χ 2 = 29.338, df = 6, p = 5.25 × 10 −5 ), indicating strong behavioural modulation in response to LDPE leachates ( Table 1 ).

The difference in errors between shallow (LIPd: −0.2 ± 1.4% [P = 0.86]) and deep (LIPv: 15.7 ± 3.4% [P = 6.1e-05]) injections was highly significant (P = 5.3e-05, two-sided permutation test).

Notably, Cryptosporidium was detected exclusively in Chinese blue-tailed skinks, with its prevalence showing a highly significant difference between the two hosts ( p = 5.32 × 10 −5 , Fisher’s exact test).

The IVW regression showed a highly significant association between the 11 SNPs used as genetic instruments of exposure and risk of developing MM (coeff = 1.175, 95% CI 0.61–1.75, P = 5.38 × 10 −5 ), whereas the MR-Egger regression showed a statistically non-significant association (coeff = 0.532, 95% CI −1.16 to 2.22, P = 0.538), although in line with IVW regression, with the intercept slightly, but not significantly, different from zero (intercept = 0.06, 95% CI −0.09 to 0.20, P = 0.428).

Trends of Antipsychotic Prescriptions The rates of antipsychotic monotherapy in 2001, 2006, 2011, 2016 and 2021 were 32.0%, 33.7%, 32.8%, 37.6% and 41.5%, respectively, with an increasing trend (χ2 = 16.3, df = 1, p = 5.4×10 −5 ) ( Table 1 ).

The highly significant association is replicated ( P = 5.4 × 10 −5 ) with an estimated OR of 1.9 (95% CI, 1.2-2.6).

In Cox regression, patients with multihit abnormalities had a 2.89-fold increased risk of death compared with those with wild-type TP53 (95% CI, 1.88-4.43), and those with single-hit abnormalities had a 1.63-fold increased risk of death (95% CI, 0.91-2.91) compared with those with wild-type TP53 ( Figure 2 D), with a significant trend in the HR as the number of TP53 abnormalities increased (likelihood ratio test, P = 5.42 × 10 −5 ).

Patients with multi-site cancers demonstrated a notably higher cumulative incidence of irAEs compared to melanoma patients, with the difference being highly significant ( P = 0.0000546).

When GWAS was performed in the 113 11q-deletion cases and 282 controls (78 undeleted 11q and 204 MNA neuroblastomas, Methods) of European-American ancestry, the 11q22.2 locus was still nominally significant (rs10895322, P = 5.50 × 10 −5 , OR = 2.811, logistic regression test, Supplementary Table 6 ), indicating a unique and independent role of the 11q22.2 locus in the 11q deletion cases.

While the enrichment of the mTOR signaling KEGG pathway (hsa04150) was not statistically significant, the enrichment of genes from a manually curated mTOR signaling network [57] was highly significant in our dataset (p = 5.5×10 −5 ).

Lists of representative genes involved in particular GO terms in each contrast are presented in Additional file 5 . “Luteal regression over luteolysis”: GO terms having highly significant association with genes upregulated in the luteal regression group are: extracellular matrix ( p = 5.52e-05) and matrix organization ( p = 0.001), steroid hormone mediated signaling ( p = 2.29e-04) and steroid hormone receptor activity ( p = 1.63e-04), regulation of gene expression ( p = 7.40e-04), negative regulation of transcription from RNA polymerase II promoter ( p = 5.02e-05), and regulation of transcription, DNA-templated ( p = 2.45e-04), as well as positive regulation of epithelial cell proliferation ( p = 3.4e-03).

The comparison of patients carrying TP53 mutation ( TP53 -mut) to patients without TP53 mutation ( TP53 -wt) revealed a highly significant association between TP53 mutations and higher age ( P =5.54 × 10 −5 ; median age at sampling 69.3 for TP53 -mut and 62.4 for TP53 -wt; Figure 2a ).

We discovered that there was a highly significant over-representation of genes involved in development amongst spatially clustered T-DMRs that are hypomethylated in MBCs versus CVS (p = 0.00005574).

All pairwise comparisons between groups did not reach statistical significance except for the comparison of PR interval by age group (ANOVA P = 5.6E-05).

Compared to results from the primary epigenome-wide mediation models, the mediation effects of CpGs across all cardiometabolic outcomes were slightly attenuated after accounting for smoking; however, all CpGs remained nominally significant (p < 5.6E-05).