Excerpts

We identified highly significant correlation differences between incident CAD cases and controls ( p < 5 × 10 –5 ); eGFR correlated more strongly with 3-hydroxyisobutyrate ( r case-to-control = 0.29), citrate ( r case-to-control = 0.42), and glycine ( r case-to-control = 0.35), while 4-deoxyerythronic acid correlated less strongly with triglycerides ( r case-to-control = −0.35), and hypoxanthine with creatinine ( r case-to-control = −0.30) in individuals with incident CAD.

However, a number of methylation probes were nominally significant in each analysis ( p < 5 × 10 −5 , detailed in the Supplementary Information ).

We found that the pair of chromosomes 4 and 5 show highly significant nonindependence across the set of crosses (Bonferroni adj., p = 5 × 10 −5 , permutation test, Figure 5B ), suggesting a genetic interaction between this specific pair of chromosomes.

The difference in the distributions of the number of viable daughter cells per mother cell is statistically highly significant with a p -value < 0.00005 (two-sample t -test).

When the same analysis was run three times, comparing the intention-offloading/nonoffloading task with the other tasks one by one, the intention-offloading/nonoffloading predictor was always highly significant, t (990) > 4.0, p < .00005, but none of the other three was, t (990) < 1.35, p > .17.

Taking a total of a 20-week interval (as transmission events between hospital cases with an onset further than 20 weeks apart is assumed to be unlikely), the model revealed a highly significant Box-Pierce Q-statistic (X 2 = 54.59, degrees of freedom (df) = 20, p = 0.00005), indicating non-independence.

There was such increases of 4.4 dB for each of the groups Education , Other and Music , and they were highly significant (p<0.00005, Tukey's HSD).

To gain further insights into their upstream kinases, we conducted a motif enrichment analysis, revealing a prevalent sequence motif surrounding the phosphosites with a highly significant proportion of arginine at position −3 (odds ratio = 4, p = 5e−05) ( Figure 2 G).

When exposing 104C1 cells that acquire a fibroblast morphology to increasing concentrations of KDC203, we observed highly significant ( p <0.00005) dose-dependent reductions in PrP C levels ( Fig 2A ).

BALB/c mice vaccinated with 20 μg of SLA plus 50 μg of CpG ODN showed a highly significant (P<5×10 −5 ) reduction in swelling compared to SLA-vaccinated mice and enhanced survival compared to unvaccinated mice.

Figure 1 presents the corresponding Manhattan plot showing the p -value (−log10 p ) of each SNP analyzed as well as indicating both thresholds for significance (the GWAS p -value of significance and the p -value suggestive of significance; p < 5 × 10 −5 ).

Across the significant surprise effects, this yielded a highly significant positive correlation (r = 0.75, p < 0.00005; Fig. 2C ).

The difference between the performance of two group in OSPE was highly significant ( P < 0.00005).

Moreover, we compute the Pearson correlation coefficient (r) and mean absolute error (MAE) for cellularity estimations, and the results show that the estimated cellularity of CLImAT-HET has a highly significant positive correlation (r > 0.99, p -value < 5 × 10 −5 , MAE < = 0.02) with the underlying cellularity across all simulated samples (Fig. 3a , b and c ), which demonstrates CLImAT-HET’s ability to precisely recover clonal architecture.

The difference between male and female patients was highly significant ( P = 0.00005, χ 2 test).

A recent GWA meta-analysis in Crohn's disease identified 74 independent SNPs as nominally significant ( p <5×10 −5 ) [24] .

SALINAS TABLE III.-Number of sera in each patient group with tumour-marker elevations Tumour marker l I SA 1 (3%) 4 (33%) 16 (94%) AGP 1 (3%) 1 (8%) 11 (64%) AAT 0 0 13 (76%) HPT 1 (3%) 0 7 (41%) AMG 0 2 (17%) 1 (6%) Abbreviations: as in Table II. extremely significant (F = 73 6 with 3 and 117 degrees of freedom, P < 0.00005).

Using a highly significant P value cutoff ( P < 0.00005), we identified 12 proteins that exhibit differential expression between these OA subsets (Figure 3 ).

This revealed a highly significant correlation (r = 0.80, p<0.00005; Appendix 2—figure 1D ).

In particular, contrary to males, mutant females showed highly significant upregulation of Neuropeptide-like precursor 4 ( nplp4 ) and target of brain insulin ( tobi ) genes ( p = 5 × 10 −5 ).

However, Filtek sealed in water shows a highly significant increase in roughness as early as 1 day ( p ≈ 5 × 10 −5 ) that continues at 7, 14 and 90 days.

A total of 1,313 SNPs demonstrated borderline significance ( P < 5*10 −5 ).

Moreover, 138 and 176 SNPs were found to have suggestive (moderately significant) association with RFI1 and RFI2 at p < 5 × 10 -5 , of which 124 SNPs have been found to be associated with both traits.

A highly significant ( p value < 0.00005) likelihood ratio test compared to a standard logistic model supported that the mixed-effects model was better fit for our data.

In contrast, when used in the study of 120 colorectal cancers, these four markers detected a LOH in 38 out of 85 informative cases (45%), a difference that is highly significant (X = 16.38; P<0.00005).