Excerpts

Correlation between PD and PDR performance We found a highly significant, positive correlation (Spearman's rank correlation, r = 0.72, p = 0.00007) between the individual performances in the PD and PDR tasks, i.e. subjects that needed a high number of trials to reach the criterion in the visual discrimination task also needed a high number of trials to reach the criteri

In addition, although it was not statistically significant after correction of multiple comparison, rs2074262 showed a trend of association with mRNA expression of RAR related orphan receptor A (RORA, P = 0.00007) and somatostatin receptor 3 (SSTR3, P = 0.0001) gene in expression quatitative trait loci (eQTL) analysis using ENCODE dataset ( https://www.encodeproject.org ).

The model demonstrated strong predictive performance (AIC = 679.94, concordance index = 0.84) with a highly significant global log-rank p-value (p = 7.07 × 10 -5 ).

However, we detected highly significant linkage disequilibrium for 3 nuclear locus-pairs across populations after a sequential Bonferroni correction for k tests ( k = 703, p < 7.1 × 10 -5 ): One_MHC2-190 ( I = 0.433) and One_MHC2-251 ( I = 0.465); One_Tf_ex10-7 ( I = 0.632) and One_Tf_ex3-18 ( I = 0.084); One_GPDH ( I = 0.668) and One_GPDH2 ( I = 0.082).

First, we investigated the possible role of DRB1*03:01 in MS susceptibility and we observed a highly significant effect: OR = 1.52, 95% CI 1.23–1.88, p = 7.1*10 −5 .

We observed a highly significant causal effect of MCP on AD [IVW (OR = 1.12, 95%CI = 1.06‐1.18, p = 7.14 x 10 ‐5 )].

For EMBP, a downregulation in plasma was observed for both inhibitors (Figure 2 ) but was nominally significant for reslizumab ( p value = 7.16E‐05).

5A , the triple combination of enalapril (3.0 mg/kg), furosemide (2.0 mg/kg) and amlodipine (1.0 mg/kg) could decrease the MBP by −18.34 mmHg ± 2.75 mmHg, which was highly significant in comparison to placebo effects ( p = 0.000073) but narrowly missed the therapeutic goal of −20.4 mmHg (averaged MBP increase induced by renal interventions, pre RW versus week 14–58).

The effect size ratio is highly significant (OR 1.60, 95% CI 1.27 to 2.02, p=7.36×10 −5 ).

The pooled difference between Sr6 positive and null plants at 18 °C was highly significant ( p = 0.000074), whereas no significant difference was observed at 25 °C ( p = 0.75) (Fig. 2B ).

Abundance estimates provided by RepeatMasker showed highly significant positive correlation with those yielded by RepeatExplorer in both the Southern (Spearman r s = 0.84, N = 15, P = 0.000074) and Northern (r s = 0.97, N = 17, P < 0.000001) lineages.

The observed count is therefore highly significant ( p = 7.4 × 10−5).

Hence, the top 10% of BILs (21) were regarded as the “LF group,” and the bottom 15% of BILs (26) comprised the “SF group.” T ‐test analysis of the FL trait for the LF versus SF groups showed an extremely significant difference ( P = 7.41E−5; Figure S15 ).

ANOVA analysis revealed a highly significant effect of temperature on the immobilized enzyme, with a large F-statistic [F(9,20) = 7.75] and a very low P-value (p = 7.48 × 10 −5 ) (Supplementary Table 3 a and 3 b).

6 G), obtained by stratifying lung cancer patients into low or high risk strata depended on four model gene expression, presented highly significant survival differences ( p = 7.5e-5).

The correlation between the NME close to the TSS and the gene expression variability was highly significant (Pearson correlation test, average correlation = 0.23, average 95% CI = [0.21, 0.25], average P = 7.6 × 10 −5 ).

For the H3K4me3 mark, the separation at the level of PC1 = 0 was highly significant (p = 7.6x10 -5 , Fig 2A ), but not at lower PCs (see PC1 to PC5 in S3 Fig ).

The probability of all eight of the low MOI lineages going extinct, but none of the others, was highly significant (one‐tailed Fisher's exact test, df = 1, P = 7.7 × 10 −5 ).

The plot reveals a clear trend towards fewer AS events per exon as the number of exons increases ( r = −0.649, P = 7.755e‐05), although the pattern is less clear for genes containing more than 25 exons (Figure 3 a).

As shown in Table 3 , the PT1 group revealed highly significant differences from baseline to 3 months for Shannon index ( adj. p = 0.000078), observed species ( adj. p = 0.000025), and phylogenetic diversity ( adj. p = 0.000001).

Figure 3F at the individual level, strengthens the men and women differences while showing an extremely significant correlation in the AL-208 group, R = 0.8268, ***P = 0.000078 between the change from baseline at 6- and 24-h extracorporeal circulation, the placebo group showed a more moderate correlation with time R = 0.6341, P = 0.0199.

Single peak promoters in our filtered dataset of 4,481 promoters had highly significant (Fisher's exact test, Bonferroni-corrected p-value < 7.8E -5 ) enrichment for the TATA-box binding motif, a confirmation of previous findings [ 8 ].

This difference between SNP types was highly significant (GLME with binomial family of error distribution, LRT against null model, p ‐value = 7.874699e−05).

We observed a highly significant overlap between the DE genes from the two studies, using either a rank-rank hypergeometric overlap test (p = 7.9 × 10 −5 ; Methods), or a standard hypergeometric overlap test for genes DE at p < 0.05 in both studies (p = 2.03 × 10 −25 ).

However, the correlation of body weights of mice at 8 wk of age fed a low-fat diet to the change in fat mass from 8–12 wk of age was highly significant ( R = 0.364; P = 7.99 × 10 −05 ).