Excerpts

The results showed pathways involved in repairing damaged nucleotides/DNA as highly significant in determining alkylating agent sensitivity: the Fanconi anemia pathway, ( p = 1.04 × 10 −35 ), homologous recombination (2.00 × 10 −24 ), nucleotide excision repair (2.77 × 10 −9 ), and non-homologous end-joining (1.04 × 10 −7 ) ( Figure 6 ). 3.

P values identified CodY as ontology term more likely to be significant among genes with higher transcript levels at 15 min ( P = 1.28*10 −35 ), 30 min ( P = 1.17*10 −45 ) and 18 h ( P = 0.0000802).

Of note, in agreement with the known relationship between ΔAUC CP /ΔAUC GLU and GLUSENS in the general population, in our population of renal transplant patients, we also observed a quite high correlation between the two, as mirrored by the highly significant p -value ( p = 2.22 × 10 −35 ).

The different response to hc‐IEDs for sample entropy and delta power was highly significant ( p = 6.3 × 10 −35 , Wilcoxon rank‐sum test).

This may be the source of the highly significant association signal we observed in our dataset for all three genetic models (DOM: P = 9.33×10 −35 ; ADD: P = 7.48×10 −30 ; REC: P = 5.27×10 −6 ).

There was highly significant non-independence ( P-value = 1.8 × 10 −34 ) between the two predictions, driven primarily by the large proportion (66%) of SNPs predicted to be benign by PolyPhen and tolerant by SIFT.

In the liver, six highly significant modules were identified ( Figure 4 A–D and Figure S6 ): MEbrown (cor = 0.85, p = 2.3 × 10 −34 ; transcripts no. = 119), MEblack (cor = 0.83, p = 1 × 10 −200 ; transcripts no. = 925), MEcyan (cor = 0.54, p = 0.0012; transcripts no. = 33), MEsalmon (cor = 0.63, p = 8.5 × 10 −05 ; transcripts no. = 33), MEgreen (cor = 0.68, p = 3.1 × 10 −22 ; transcripts no. = 154), and MEgreenyellow (cor = 0.34, p = 0.049; transcripts no. = 34) ( Figure S7A–F and Figure 4 E–K).

A second, highly significant set of associated variants in 1q32.2 was defined by the lead SNP rs570516915 ( P = 5.25 × 10 –34 , OR = 8.65, Fig. 2b ).

After using k-means clustering to assign individuals to two different groups according to their coordinates in the PCoA, a highly significant association ( P = 5.41 × 10 -34 ) between the k-means assignments (n cluster1 = 531, n cluster2 = 118) and breeding program subgroups (n subgroup1 = 352, n subgroup2 = 297) was found.

This represented a highly significant difference (two-way analysis of variance (ANOVA) with factors young/adult stage, and individual monkey; F 1,304 =189.7 for main effect of stage, P =7.2 × 10 −34 ).

The results revealed an important positive correlation with a coefficient of determination R 2 = 0.72 and a highly significant p-value (p = 7.51 × 10 −34 ), indicating a robust linear relationship.

Other highly significant pathways included skeletal system development ( p = 8.431 × 10 −34 ), cartilage development ( p = 8.904 × 10 −34 ), and ossification ( p = 1.231 × 10 −33 ).

This analysis revealed a novel variant, rs148726219, located on chromosome 19q13.32 (>500 kb from APOE ) which showed highly significant association with AD in DF3 (p = 8.9e-34, OR = 2.5) and had further increased significance in the later release DF6 (p = 2.7e-54).

Notably, there is highly significant overlap ( P < 1 × 10 −33 ) between the WHSC1 target genes identified and the differentially expressed genes in KMS-11/Cfz (86 out of 887; FC ≥ 1.4) and KMS-34/Cfz (69 out of 888 genes, FC ≥ 1.5).

Support Vector Machines achieved 84.06% accuracy and 93.56% sensitivity, with highly significant group differences across all features ( p < 10 −33 ; Cohen's | d | = 0.87–1.51).

cholerae and rotavirus was highly significant (p = 1.12 × 10 –33 ).

Further analysis of the differentially methylated probes in all primary human keratinocytes from 13 different donors also showed a moderate, but robust and highly significant ( p = 1.4 × 10 −33 , t -test) reduction of DNA methylation in the DHM-treated cells ( Figure 2B ).

This represents a highly significant overlap (Fisher Exact Test p-value = 1.45E-33).

These differences were highly significant by Mann–Whitney U tests (P ≈ 1.7 × 10 −33 for SOX2_Gradient, 9.4 × 10 −24 for SOX2_Tile_Gini, 3.2 × 10 −25 for CD44_HScore, and 2.4 × 10 −12 for Prague M).

We found that HOXC8-ssr , HOXC8-3end and HOXC11 all showed highly significant significant linkage to Crest ( P = 5.5×10 −33 ) with no recombination event detected ( Fig. 2 , Table S3 and S4 ).

For example, the probability of finding a lower co-occurrence than observed for the GO terms “RNA processing” (GO:0006396) and “signaling” (GO:0023052) is very low in human (therefore highly significant), as indicated by their AP , p = 7.5e-33 (Figure 2 ).

Specifically, we first applied Cochran's Q test across all three models, which revealed a highly significant global difference ( Q = 147.72, p = 8.36 × 10 −33 ).

Likewise, wear resistance and marginal integrity exhibited highly significant changes between follow-up periods, especially between T2 and T3 ( p < 10 −32 and p < 10 −38 , respectively).

A highly significant positive correlation ( p value < 1e−32; R 2 = 0.59) was observed between the total number of additional HGs formed within a Pango lineage and the total number of genomes assigned to that lineage.

A GEE analysis, with robust SEs, adjusted for age, sex, cognitive state, APOE‐ε4 status, years of education, and recruitment site, indicated a highly significant overall group effect on BAGs ( χ 2 (4) = 156.07, p < 10 − 32 ).