Barely Significant

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highly significantp -value <0.00010.0× alphaqualifiedgold
Indeed, we observed complete or near complete LD for all pairs of SNPs with sufficiently high frequencies (only alleles with frequencies in the range 0.05–0.95 were included in the analysis because estimates of LD for low-frequency alleles in small samples are not informative): 85% of all pairwise r 2 values were highly significant (Exact p -value <0.0001).
showed a trendP<0.00010.0× alpha
On the other hand, the group of subjects who received PI vaccination showed a trend toward an increase in the median IgG titer (median values of 0.3 to 579 (P<0.0001), 0.00–401.4 (P = 0.3125), and 971.3 to 2163 (P = 0.3008) in group 1,2, and 3 respectively), except slight decrease of IgG value for Group 4 (median value of 1067 to 1021; P = 0.9717).
a significant trendP < 0.00010.0× alphagold
According to data published by the Companion Animal Parasite Council website ( www.capcvet.org ), the percentage of Ohio dogs tested positive for exposure to the Lyme disease spirochete by the SNAP 4Dx Plus Test was 0.39% (218 of 54,963) for 2011, 0.55% (250 of 45,376) for 2012, 0.56% for 2013 (543 of 96,016), and 0.62% (102 of 16,343) for 2014 as of April 23, 2014, showing a significant trend of increase ( P < 0.0001, Chi-square test for trend).
highly significantp<0.00010.0× alphaqualifiedgold
Correlation between capillary TSH and venous fT4 testing There was a strong correlation between capillary TSH at screening and confirmatory venous fT4 testing following referral with a highly significant Spearman’s rank correlation coefficient of −0.707355 (p<0.0001, 95% CI after using Fisher’s Z transformed −0.760912 to −0.644225).
highly significantp < 0.00010.0× alphaqualifiedgold
Further we found that tests for differences in the distributions of transition types for different starting syllables across contexts were also highly significant (not random), including for the m syllable [T X 2 (obs.) = 5167.109, df = 684, p < 0.0001; Figure 9 and Appendix A in Supplementary Material]; pair-wise comparisons using Chi-squared tests for each pair of contexts showed strong statistical differences (Figure 9 and Appendix A in Supplementary Material: p < 0.0001).