Excerpts

(2016) , with a highly significant overlap in the composition of each defect group between cohorts (minimal P -value <1 × 10 −40 ; Fisher's exact test) ( Supplemental Fig.

The PSs for TG (30 SNPs), LDL-C (28 SNPs), and HDL-C (60 SNPs) explained a relatively small, but highly significant, proportion of the variance (5.6 % [F = 157, P = 1.7 × 10 −40 ], 3.1 % [F = 99, P = 6.2 × 10 −27 ] and 5.1 % [F = 164, P = 1.1 × 10 −36 ]; Additional file 6 ) and were not associated with confounders (Additional file 7 ) with the exception of the HDL-C PS, which was associated with confounder neutrophil counts ( P value = 1.8 × 10 −2 ).

Category II SNPs (SNPs with less functional evidence than Category I) also showed highly significant enrichment for low P-values (fold enrichment 1.42; P = 2.60e-40) ( Table 3 ).

We found a large (n = 98) and highly significant (p = 2.8e−40) overlap between the splicing events regulated by QKI and RBFOX2 ( Figure 4 D).

When we compared the expression of all genes located within regions with significantly altered compartment scores, we observed a highly significant trend towards an increase in expression of genes with an increased compartment score and vice versa (Fig. 7a , top right; p = 2.99e-40).

The difference in the average number of trabeculae/embryo between mild and severe mutants was extraordinarily significant as determined via Student’s t -test ( P =4×10 −40 ).

Intima-Media Thickness and Genetic OAG Risk First, we validated the association between the OAG-GRS and OAG, which was highly significant ( P = 4.8 * 10 −40 ), with an OR of 2.44 (95% CI = 2.13–2.78) for each standard deviation increase in OAG-GRS.

This positive association is highly significant when compared to the whole population ( P = 7e‐40).

The difference in fit of the 13 models was highly significant ( p = 8 × 10 −40 , ANOVA), but there was no significant difference in the fits of the five top models, all of which incorporated a perseverative learning mechanism: Perseveration/Reward-learning model (PR model, ref. 36 ); differential forgetting Q -learning 33 ; ideal observer with perseveration (see Methods); ideal-observer Bayesian filters with perseveration for either a generic probabilistic reversal-learning task (see Methods), or a generic drifting reward probability task 37 .

Moreover, the SII demonstrated a consistent annual increase, with regression results indicating extremely significant statistical relevance (P = 9.3E−40).

In continuous light, there was a highly significant correlation between sister cell generation times ( R = 0.87, P < 1 × 10 –39 , Fig. 4c ), suggesting that the observed variation in generation times across all cells was not entirely stochastic.

The mean Pearson correlation between speed and HθWP after SAL and CNO injection were 0.44 ± 0.04 and 0.36 ± 0.07, respectively, reflecting a highly significant correlation in both cases (mean p < 10 −39 ).

There was a highly significant trend in increased risk associated with BMI categories of ≥25 to <30 and ≥30 ( P = 1.4 × 10 −39 ).

A highly significant reduction ( p = 2.3 × 10 –39 ) in the number of Candida colonies was observed in the treatment arm when comparing pre- and post-study results.

The total GRS based on 80 known index SNPs showed a highly significant association with T2D (OR 1.07 [95% CI 1.06–1.08] per risk allele; P = 2.31 × 10 −39 ) ( Table 2 ).

There was a highly significant correlation between relative amounts estimated based on OTU counts and on raw reads data (Pearson c = 0.9947; p = 3∙10 −39 ; Supplementary Figure 3 ).

falciparum ’s large proteins displayed unique and parasite-specific annotations, with a highly significant presence of host cell binding functions ( P = 3.21e−39) compared to the rest of the proteome.

The results of the test were highly significant ( P = 3.41 × 10 −39 ; Fig. 4c, d ), proving that there is a strong relationship between the data-driven GGM and the known IgG glycosylation pathway.

S4b ), we found a highly significant peak on chromosome 17 (Fig. 6a , Supplementary Data 5 and 6 ) where the lead variant was an intergenic SNP upstream of the BMP2 gene (chr17:15643342:C>T, P = 3.45 × 10 − 39 ).

IPA upstream analysis estimated module-specific upstream regulators, including transcription factors (Table S2 ), and suggested that the transcription factor MITF was activated in co-module #12, which was highly significant among co-modules (IPA overlap p-value = 6.91E-39, Fig.

This correlation was highly significant ( Fig 5B ; P value = 7.1x10 -39 ; linear regression), suggesting that the variation in additive effects of polymorphisms across the 20 environments, rather than the effect size, was associated with the changes in activity of interactions in the epistatic network.

Remarkably, 35 insertions are located at common insertion sites (CISs), a highly significant result (Fisher's exact test p = 7.4×10 −39 ) ( Table 1 ).

These results were corroborated by the analysis of functional pathways using the ConsensusPathDB 25 (Methods); gene sets showed highly significant overlaps ( P <7.66 × 10 −39 –2.38 × 10 −05 ) with pathways involving OR and GPCR-related signalling and signal transduction, (extra-cellular matrix related) processes of inter-cellular communication, immunoregulatory processes and membrane-linked drug transport.

4c ) show that the TE and ICM nuclei in blastocyst embryos have highly significant differences in the mean nuclear dry mass density ( p -value = 8.11e−39), while the differences for cleavage state embryos are nonsignificant ( p -value = 0.0105).

To further investigate the significance of these directional findings we estimated the differences in the slopes using z-scores and demonstrated that for 31 of the 35 genes the differences were highly significant (Bonferroni corrected p<1×10 −38 ) ( Supplementary Table 4 ), thus strongly suggesting these were not chance observations.