In the current study, we demonstrate nominally significant hypermethylation at both loci (Fig. 4 a: cg05066959: ∆ = 13.10, P = 1.13 × 10 −4 and Fig. 4 b: cg11823178: ∆ = 9.39, P = 5.48 × 10 −5 ), in parallel with a nominally significant decrease in uC (cg11823178: ∆ = − 5.03, P = 1.19 × 10 −3 ; cg05066959: ∆ = − 9.06, P = 1.18 × 10 −4 ), and a nominally significant decrease in 5hmC at cg11823178 (∆ = − 4.36, P = 0.02), with a non-significant decrease in 5hmC at cg05066959 ( ∆ = − 4.04, P = 0.14).
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The inclusion of covariates slightly reduced the association p -value of the loci ( P = 7.01 × 10 −8 ; without covariate analysis), showing a nominally significant effect of Bristol stool scale ( P = 1.13 × 10 −4 ).
Conversely, in the MIIP group, only one 6-week-old piglet tested positive for the virus, a statistically highly significant difference compared to the 100% infection rate in the control group ( p = 0.0001191).
Within the Araneoidea lineage sampled in our analysis (Araneidae, Nephilidae, Linyphiidae, Tetragnathidae, Theridiidae), there was a clear trend of decreases in genome size and repeat content, supported by the strong positive correlation observed across the available genomes (Pearson's r = 0.74, P = 1.2 × 10 −4 ).
Fungal infection experiment First we tested whether males and females differ in their survival, which is highly significant for sex (n = 378, Z = -3.84, p = 0.00012) and treatment (n = 378, Z = -4.67, p < 0.0001) (Fig. 3a ), therefore fungal treatment reduced survival differently depending on sex, and females survived better.
Although here statistical significance was not reached for any dosage group alone, the Poisson trend statistic [ 32 ] suggested a highly significant (p = 0.00012) decreasing trend in tumor incidence rate over the dose range from 4 Gy to 16 Gy.
Assigning ABC and GCB phenotypes to these groups of samples, Goeman's global test found a highly significant association ( p = 0.00012) of the ABC and GCB phenotypes with the DLBCL ABC and GCB predictor gene set.
The co-treatment with both agents to the diabetic rats (Group 7) resulted in normalization of FBG with a highly significant difference as compared to the diabetic group ( p =0.00012) and was lower than that in the diabetic rats treated with metformin (Group 8).
10 4 /mL blood), intriguingly, CD33 and CD64 showed a highly significant inverse profile in this study ( p = 0.00012; Figure 3 A right).
This enrichment for proteins with 3 or more copies of the RXXS motif is highly significant (p = 1.2 × 10 -4 ; G.
By applying the threshold of 5% tumor-infiltrating lymphocytes (TILs) we defined two groups, hot and cold tumors, which show a highly significant difference in TIL percentage (p<0.00012).
In this analysis, the correlation coefficient among the methods was moderate and highly significant ( r = 0.465; p = 1.2e − 4).
The increase in the percentage of dead SH-SY5Y cells under the influence of antibodies from the patients with schizophrenia was highly significant in comparison with the culture medium alone ( p = 0.00012), and the difference from the healthy donor control was even greater ( p = 0.000003).
The difference between the figures of the MWT values obtained from control and CFA-treated rats was highly significant ( p = 0.000125).
Nonetheless, the contingency table of type collected at each health facility ( Supplementary Table 4 , Supplementary File 1 ) reveals highly significant evidence to reject independence of type occurrence at each health facility (G statistic = 849.7, dof = 704, P = 1.25×10 -4 ) in favour of clustering of type occurrence by health facility.
The associations between %-respondents for the concurrent data sets of snake encounters versus snakebite experiences showed highly significant positive correlations across the six habitat types ( r s = 0.9908, p = 0.000127, two-tailed, n = 6,), as well as across the six habitat types, three daytime periods and two seasons combined ( r s = 0.9545, p < 0.00001, two-tailed, n = 11).
When rs3747742 or rs9381040 are included as covariates in a conditional analysis, rs75932628 remains highly significant ( p = 1.27 × 10 −4 and p = 1.19 × 10 −4 , respectively) ( Fig. 1 , panel D), suggesting that the TREML2 and TREM2 signals are independent from each other.
Furthermore, in the TS cultivar, specific boundaries showed a highly significant enrichment of active gbM marks (51.6% vs. 44.3%; Δ = +7.3%, 95% CI: [3.5%, 11.1%], Cohen's h = 0.147, p = 1.28e‐04), whereas gbM levels were comparable in PN (Δ = −1.3%, p = 0.438) (Figure S9 ).
The heritability of SPH or SEM was highly significant (p=0.0001298 and p=0.0000006 for SPH and SE, respectively), with heritabilities of 23.2% (SPH) and 33.9% (SE).
The differences in the proportion of identified heterospecific song types between sympatric and allopatric Thrush Nightingale males were highly significant (GLM, DF1 = 1, DF2 = 15, F = 25.94, p = 0.00013), as was the difference in the proportion of Common Nightingale song types in repertoires of sympatric Thrush Nightingale and Common Nightingale males (GLM, DF1 = 1, DF2 = 15, F = 14.56, p = 0.0016).
72 kDa type IV collagenase precursor was highly significant (FC > 2; p = 0.00013).
First, the large overall differences between increasing- and decreasing-rate ACC were confirmed by a highly significant main effect of change direction ( F (1,7) = 56.94, p = 0.00013; 3-way RMANOVA: change direction × change size × base rate).
The difference was highly significant ( χ 2 = 14.6, P = 0.00013).
In the second stage, SNPs/loci that passed a significant threshold (p < 0.05) were further pruned down with bonferroni correction and only those SNPs that were highly significant (p < 0.00013, Supplementary Table 3 ), and belonged in particular, to the extracellular matrix (ECM) i.e., Aggrecan and Fibulin-1 genes were selected for genotyping, as these genes were up-regulated and associated with aPWV in the gene profiling work.
The difference was highly significant in this case ( p = 0.00013). 3.2.