Excerpts

Pearson’s correlation revealed a highly significant association between age and transcript expression for both HDAC1 : F(1,316) = 11.46, r = −0.187, p = 8 × 10 –4 and HDAC2 : F(1, 305) = 62.17, r = −0.411, p < 10 –13 .

Another clone (5B3, from pool F, Mm8 Chr16: 91155139–91157882), containing an insert located 57 kb downstream of 5A5, similarly induced expression in the trigeminal ganglion ( Figure 2 ), although in this case the penetrance of the phenotype was lower (41%, n = 22), albeit highly significant (p = 8×10 −4 ).

This difference was highly significant ( p = 0.0008).

The difference in median MFI between TN‐ and BTKi‐treated patients was also highly significant ( p = .0008; values above).

A highly significant difference was observed between the maximum stress value for the RC scaffolds versus XYP scaffolds when the deposition time was 45 min ( p = 0.0008, F = 81.55, and critical F = 7.71); however, no significant difference was observed for the elongation at break ( p = 0.24, F = 1.89, and critical F = 7.71).

The protection was highly significant, with p = 0.0008 for both treatment groups compared with the controls.

This difference between the rnr1-Y285A and rnr1-Q288A strains is highly significant ( P = 0.0008).

A positive trend of increased truncations in CSF with increased truncations in plasma was observed, with Pearson correlation coefficients of r = 0.419 ( P = 0.0008) for truncated apoC-I, and r = 0.525 ( P < 0.0001) for truncated apoC-II.

However when we differentiate the CFA+ve and CFA-ve group of enrolled CFA+ve mother during follow-up, a highly significant positive correlation was observed among the CFA +ve mothers (p = 0.0008, r2 = 0.518; Fig 5C ) in contrast to CFA-ve mothers (p = 0.47, r2 = 0.066, Fig 5D ).

Inter-annual variation in macroalgae cover was significant in five of the six study regions, and two of these displayed a significant trend over time with cover levels increasing in Baltic Proper inner (linear regression; P = 0.0008) and west coast inner (linear regression; P = 0.0182) (Online Resource 1).

The distribution of hypermethylation and hypomethylation loci among comparison pairs was highly significant (χ 2 (2-df) = 14.17, P = 0.0008).

For the SPHLJ positive SARS-CoV-2 RT–PCR tests, the period from June 2020 to May 2021 showed a highly significant Granger causality association ( p = 0.0008), indicating that Ct values effectively predicted changes in this metric.

However, gamma coherence showed highly significant increases during choice compared to must-touch between mPFC and vCA1 ( Figures 1 G and S3 B; mPFC-vCA1 t(3) = 13.760, p = 0.0008), similar to changes reported from T-maze DNMTS tasks. 18 , 19 In addition we found marginal increases in gamma coherence between nRE and vCA1 ( Figure 1 G; nRE-vCA1 t(2) = 3.272, p = 0.082).

We identified three highly significant module-trait correlations (|AverageCorr | > 0.5, p -value < 8e-4), with each linked to DLB and Control, and composed of CpGs ranging from 39 to 157 (Supplementary Data 2 ).

The NaOCl solution caused a highly significant reduction in post-operative discomfort ( p = 0.0010 day 3; p = 0.0007 day 7) and early painful failures ( p = 0.0008) compared with the control.

NU7441 enhanced the cytotoxicity of doxorubicin 2-fold at the LD 50 concentration (doxorubicin alone: LD 50 = 12–13 nM; doxorubicin with 1 μM NU7441 LD 50 = 6 nM), and for both cell lines this effect was highly significant (2-way ANOVA p = 0.0008 for TC-71, p < 0.0001 for VH-64 cells).

Wilcoxon rank sum test revealed a highly significant shift towards trajectory-reliance from session 1 (median = 0.0076) to session 2 (median = 0.1973; w = 116, p -value = 0.0008, r = 0.5128), from session 1 (median = 0.0076) to session 3 (median = 0.2757; w = 46, p -value < 10 −5 , r = 0.6781), from session 1 (median = 0.0076) to session 6 (median = 1.0241; w = 2, p -value < 10 −8 , r = 0.7385), from session 2 (median = 0.1973) to session 6 (median = 1.0241; w = 16, p -value = 0.0001, r = 0.6953) and from session 3 (median = 0.2757) to session 6 (median = 1.0241; w = 20, p -value = 0.0014, r = 0.6534).

Whilst in the untreated culture medium, the levels of IL1β were undetectable, in LPS-treated cultures, there was an average of 6 pg/ml IL1β detected, representing a highly significant increase (*** p = 0.0008) (Fig. 3 a).

Nevertheless, ANOVA across the three biomarkers of neural cell development indicated highly significant differences among the three groups ( p < 0.0008) that depended both upon the specific measure and brain region (treatment × measure × region, p < 0.0002).

This overlap is highly significant (OR = 2.0, p = 0.0008, Fisher’s exact test).

When considered along a composite axis [2PC1–PC2, Figure 2A ], TGFβ treatment induced significant differences [two-way ANOVA, p = 7.5e-10], and the interaction term, which assessed whether the effect of TGFβ was the same in the presence or absence of VPA, was also highly significant [ p = 0.0008] indicating that VPA did indeed alter the response to TGFβ.

Arthralgia was found to have a highly significant association (p < 0.0008) with stress scores.

While healthy participants showed a highly significant intervention effect on change in global cognition, t (86) = 3.48, p = 0.0008, Cohen’s d = 0.54, participants with MCI, t (108) = 1.45, p = 0.15, Cohen’s d = 0.19, and dementia, t (25) = 0.14, p = 0.89, Cohen’s d = 0.04, did not show a significant improvement.

2A to D ), and the highly significant ( P = 0.0008) reduction in bacterial resistance to some antibiotics from IIS to WWE ( Fig. 2B ), reinforces the need for adequate water treatment for all and preventing natural environmental surface waters having similar community profiles to untreated wastewater.

A highly significant positive correlation between maintaining attention and motivation was found (Spearman correlation, R = 0.53, p = 0.0008).