Excerpts

The difference between the groups was highly significant ( P = 8.20 × 10 −4 ; see also fig. 4 A ).

In the Kaplan-Meier curve of the external dataset, we observed a highly significant association between the high- and low-risk groups and survival time ( p -value = 0.00082), providing strong evidence for the suitability of our model in prognostic prediction. 3.3 Multivariate cox regression analysis and TF-target gene network construction To explore other additional factors affecting CRC, a total of 317 samples, including phenotypic data, were subjected to Cox single-factor regression analysis for age, sex, pathological stage, lymphatic invasion, and risk score.

The CpG main effect of cg24223887 was nominally significant (0.263, p -value = 8.2e-04). 4 Discussion Telomere length is a biomarker of ageing and early-life telomere length relates to later life telomere length and may underlie ageing-related diseases.

However, improvement of proteoglycan coverage with the addition of PNGase F was highly significant ( p = 0.00082) when the Gnd-HCl fraction was taken into account.

Of these NHL-W risk factors, dementia was nominally significant and had a similar effect size in HL (OR 3.7 [1.8–7.0], p = 8.3 × 10 −4 ).

Additionally, there was a slightly significant negative correlation between RA and MS (correlation coefficient = -0.46, P = 8.3 × 10 − 4 ), and a slight but significant positive correlation between MS and T1D (correlation coefficient = 0.20, P = 0.041).

In single-SNP analyses, two of the 13 SNPs showed nominally significant associations with wet AMD (rs2241394, nominal P = 8.32×10 −4 ; rs428453, nominal P = 0.0240), of which only rs2241394 withstood multiple test corrections (corrected empirical P = 0.0102; Bonferroni-corrected P = 0.0108, Table 2 ).

Additionally, at the SL chromosome 4 locus, we identified a C > G variation (rs142551296) in PRSS12 that approached significance ( P -value = 8.4 × 10 − 4 ).

This interspecific difference was apparent by an association test (see Methods), with P = 0.00084 ( Table 1 ).

24 Again, as would be expected given a causal relationship, we observed a positive r P between PDW and PD in the UKB, although the estimate was only marginally significant (r P ∼ 0.01, p = 8.44 × 10 −4 to 0.07 depending on prevalence; Data S1 ; Table S28 ), potentially because of the modest number of PD cases in the cohort (n = 1,323 compared with >5,000 for stroke).

mansoni infection detected by CCA dipsticks from the primary data ( Kayuni et al., 2020 ), our secondary analysis finds that a positive association between IS prevalence and age was observed up to the age of 11, after which there was a decreasing trend [T+: p = 8.45e-4].

For renal function, the overall difference in eGFR across clusters did not reach statistical significance after FDr adjustment (P FDR = 0.088); post hoc pairwise comparisons indicated that SIDD had lower eGFR than SIRD ( p = 8.49 × 10 −4 ), and SIRD had lower eGFR than MARD ( p = 0.01), while other comparisons were not statistically significant ( Supplementary Table S1 ).

The correlation between fraction of polymorphic loci and percentage of identity to the ERE1 consensus sequence is highly significant (Pearson’s correlation ρ = 0.93, p = 8.5 × 10 −4 ).

The two groups showed a highly significant difference in overall survival (log‐rank p = 0.00085 Supplementary Fig. 1), with 5‐year overall survival rates of 98.1% and 87.4%, respectively.

Exploratory subgroup analysis showed that the prognostic impact of MPSol probability was clearly significant in the patients with neoadjuvant CCRT treatment ( n = 218, p = 0.00085), but it was not significant in those with definitive CCRT treatment ( n = 198, p = 0.51) ( Figure S5 ).

This overlap is highly significant (p = 8.5×10 −4 ).

In both cell lines a highly significant increase in the relative luciferase activity (Welch Two Sample t-test, p-value = 0.0008513) could be shown for constructs containing the region of interest 5 ́ to the luciferase gene compared to vectors without the respective region.

The paired t -test yields highly significant results (t = 8.944, p = 0.00086).

In contrast, variation in YFMI was highly significant (One-way ANOVA F (3, 32) = 7.109, p = 8.6 × 10 −4 ).

For miRlastic, the test yielded a highly significant p -value of p = 8 . 736821 × 10 - 4 .

In contrast, ASD polygenic risk was significantly and positively associated with college or university qualifications, and also showed a positive trend of association with fluid intelligence ( β = 0.04, uncorrected p = 8.78 × 10 −4 ), although the latter did not meet FDR correction at 0.05.

The random effect of subject was highly significant (F(22, 114) = 4.05, P = 8.8 × 10 −4 ) indicating that ISC is quite variable across subjects.

The number of men is also too large compared to women for normal mortality (highly significant difference with p = 0.0008958; chi-squared test, also written as χ2 test = 11.031).

In exploratory follow-up analyses without correction for multiple testing, we observed nominally significant associations contralateral in the left OFC ( k = 20, F = 11.15, p = 0.000897, uncorrected, p = 0.606, FWE-corrected) and also in the right lateral occipital cortex ( k = 133, F = 12.7, p = 0.0003968, uncorrected, p = 0.364, FWE-corrected).

Brachycephalic breeds were affected more frequently, primarily due to the high proportion of French Bulldogs that showed a highly significant association with CH OCLLs ( P = 0.0009; OR: 14.82; two-sided Fisher’s exact test).