“a clear trend”

73 Although much effort has been invested, it is still difficult to deduce a clear trend regarding the role of host genetics in the gut microbiome.

The analysis of the Gleason score groups revealed a clear trend, wherein higher scores were significantly associated with an increased likelihood of treatment change.

Others have reported that patients undergoing ART with low basal LH levels (< 3 IU/L) did not differ significantly from controls in terms of response to COH, but there was a clear trend toward poorer implantation and CP rates [ 14 ].

In the LFY section, although overall variability is limited, event samples define a clear trend along an oblique line between terrestrial source rocks (0.11 ± 0.10 ‰), marine carbonate (0.06 ± 0.08 ‰), and volcanic Δ 199 Hg (0.03 ± 0.05 ‰) values, indicating a volcanic signature.

Among MCS patients, in whom there was more meaningful variability in CRS-R scores, we observed a clear trend toward increasing clustering, network centrality and modular span of alpha band networks as CRS-R scores improved (dashed regression lines in figures 6A–D ).

Participant C shows a clear trend across all zones and substantially less variation.

Interestingly, the overall developmental energy increases in parallel with the EMT circuit energy, whereas the transcriptional diversity does not follow a clear trend ( Figure S6E,F ).

In the cosmetics industry, animal experiments have been banned in the EU, in toxicology there is a clear trend towards alternative methods, and in the pharmaceutical industry a rethinking of the sensible use of animal experiments is slowly beginning.

Discussion Epidemiological evidence shows a clear trend toward a worldwide increase in the incidence of TC during the past three decades; this is also the case in Japan. 5 Meanwhile, substantial differences in the incidence and trends have been observed between geographical areas, as well as between ethnic groups.

In 2018, a clear trend of decrease in proportion of triterpenoids in berry wax was observed from southern latitudes in Latvia (79.9% triterpenoids of total wax), through location in Finland (50.7% triterpenoids of total wax) to northern Norway (27.4% triterpenoids of total wax).

There did not appear to be a clear trend in participation and engagement between internationally versus locally headquartered companies; however, there was low level of engagement from companies in the quick service restaurant sector.

COVID-19 + solid cancers showed significantly reduced CD8 + T cell numbers ( Figures 5 A and S5 A) and although most significant for naive CD8 + T cells, there was a clear trend toward low counts for all CD8 + T cell subsets with the exception of T EMRA , as previously reported for non-cancer COVID-19 + ( Laing et al., 2020 ; Mathew et al., 2020 ; Wen et al., 2020 ) ( Figures 5 A, ii and S5 A).

A clear trend we uncover is a negative correlation between the percentage GC and distance from the telomere in Lepidoptera, Diptera and Coleoptera (Fig. 4 ).

Like LAL, the activity of cathepsins B and L showed a clear trend towards significant decreases in LKO mice of both sexes ( Figure 5 c–f), indicating impaired lysosomal lipid degradation and protein turnover in these mice compared to the floxed mice. 3.4.

The ratio for Tet did not reach statistical significance, but showed a clear trend.

Graphic comparison of ceftriaxone-treated and untreated slices at each glutamate concentration, revealed no significant differences in the RA or SH-exposed slices, although a clear trend of decreased excitotoxicity was apparent in ceftriaxone-treated SH slices ( Fig. 5 ).

Results 3.1 Linear impacts: Linear acceleration and skull stress are age-dependent For drop impacts at the fixed linear anvil (flat, kerbstone, kerbstone rotated), there is a clear trend that the younger age has higher peak linear acceleration and skull stress, with the youngest being the most vulnerable.

Although a clear trend in flux values was observed, a one-way ANOVA showed limited statistically significant differences, which is likely due to the limited number of replicates.

With respect to the water pouring height, it is hard to indicate a clear trend–it may be due to the too narrow height range or low bubble area dependence on this parameter.

There is a clear trend of E formula to increase with soil depth in most of the samples indicating the evolution of SOM to a higher degree of reduction as mineralization proceeds.

There was also a clear trend that the triple-negative cancer patients from the same cohort with higher AKT1 expression ( n = 74) also had poorer DFS as compared to those with lower levels ( n = 38) ( p = 0.055), although only border significance was achieved (Fig. 1e ) [ 23 ].

A clear trend of decreasing diffraction spot count with decreasing grain size is evident.

Although chi-square analysis did not reveal statistically significant differences between groups ( p > 0.05), the confidence intervals suggest a clear trend toward improved stability with Exoplan ( Table 1 ). 3.2.

Historically, surgical management was the predominant strategy; however, current literature demonstrates a clear trend toward endovascular approaches, with high technical success rates and lower morbidity and mortality compared with conventional surgery [ 1 , 3 ].

Although the overall correlation was modest, a clear trend emerged: FQs with lower IC 50 values generally ranked higher in the CDS list (Fig.