“a negative trend”

A significant reduction in the consumption of carbapenems both immediately and at the end of the study was also obtained (level change: −88.44 DOT/1000 PD; relative cumulative effect: −25%; 95% CI −0.41 to −0.09), but a negative trend change was observed (slope change: 1.32 DOT/1000 PD per quarter, P = 0.262).

Results showed a negative trend for recognition test baseline total ( R 2 = 0.037, p value = 0.27, 95% confidence intervals slope = −0.0017, 0.0005) and recognition test follow-up total ( R 2 = 0.088, p value = 0.09, 95% confidence intervals slope = −0.002, 0.002), but no statistical significance.

Conversely, a negative trend was observed in human pathogenic taxa, although not statistically significant (Pearson’s r = − 0.61, p = 0.27), likely due to the small number of genomes (Fig. 5 d).

Furthermore, SS dry eye patients exhibited a markedly elevated P2RX7 level, which displayed a negative trend, albeit not statistically significant, in correlation with miR‐31‐5p ( r = −0.4097, p = 0.2734) (Figure 9F,G ).

The untrained task remained largely unrelated at TLX1 ( r = 0.03, p = 0.90) and also showed a negative trend at TLX2 ( r = −0.25, p = 0.30).

There was a positive trend of microcephaly ( p = 0.7) and abnormal muscle tone ( p = 0.1); a negative trend was seen between autism and diagnostic yield ( p = 0.3).

When combining MR results from various data sources, these findings showed a negative trend (college completion: OR = 0.61, 95% CI: 0.23–1.61, P = 0.32; age completed full-time education: OR = 0.99, 95% CI: 0.99–1.00, P < 0.0001).

A large cross-sectional study conducted on data from 2619 non-clinical subjects found a non-significant positive association between Toxoplasma seropositivity and drug addictive disorder in men (odds ratio = 3.29, p = 0.01) and a negative trend for women (odds ratio = 0.51, p = 0.32) [ 185 ].

Employment status showed a negative trend (OR = −0.357; Exp(OR) = 0.700; p = 0.330), suggesting that certain changes in employment status are associated with an approximate 30% reduction in the probability of resilience.

In parallel to these hypotheses, our results also demonstrated that lower PNI levels had a negative trend for prognosis (9.3 vs. 16.2 months, p =0.35).

A negative trend was noted also for benzodiazepine derivatives (Z), although neither group showed a statistically significant change (PD alone: R = −0.63, p = 0.35; PD with co-occurring psychiatric conditions: R = −0.062, p = 0.6).

Median DOR showed a negative trend ( r = −0.20, P = 0.378) against median OS, which may have been confounded by the negative trend ( r = −0.36, P = 0.096) observed between ORR and median DOR in the ICI-based regimens ( Supplementary Figure S1 , available at https://doi.org/10.1016/j.esmoop.2025.105754 ).

Similarly, weight changes also exhibited a negative trend with ghrelin levels ( β = −0.40, 95% CI: −1.29–0.49, p = 0.380), but this association was not significant, with no explanatory power ( R 2 = 0.00%).

The proportion of naive T cells showed a negative trend association with the 17‐item Hamilton Depression Rating Scale (HAMD‐17, r = −0.22, p = 0.39) or 16‐item Quick Inventory of Depressive Symptomology–Self‐Report (QIDS, r = −0.37, p = 0.10) scores, which was not seen in GZMH + CD8 + Tm cells (Figure 2B–D,F–H ).

For state 3, the WAB‐AQ scores showed a negative trend with both FT ( r = −0.328, p = 0.393) and MDT ( r = −0.382, p = 0.225), but the correlation was not significant. 4 Discussion The present study employed the ICA‐based sliding window technique and k ‐means clustering method to investigate alterations in dFNC and the relationship between the temporal properties of dynamic networks in patients with PSA and language dysfunction.

Roxadustat showed a negative trend with a medium effect size (Cliff’s delta = -0.56, p = 0.400) and a mean difference of -0.34 (95% CI [-1.02 to 0.34]).

The neck pain results showed a negative trend of having a lower index value for subjects reporting neck pain vs. patients without neck pain [ p = 0.440, A = 0.636, p(P < A) = 0.03].

Conversely, for participants with a family history of AD (FH+), there was a positive trend between vitamin B12 intake and connectivity in IC 8 (beta value = 0.0007; p = 0.4703), and a negative trend for IC 19 (beta value −0.0006; p = 0.4549), although these trends were not statistically significant.

In women, positive trends between the time elapsed since COVID-19 infection onset (less than 2 years) and physical health (Tau = 0.050, P = .51), mental health (0.044, P = .56), and reaction time (0.035, P = .63), with fatigue being significantly affected (Tau = 0.158, P = .039), and also a negative trend with error rates (Tau = −0.055, P = .46) were observed.

The model indicated a negative trend in AMH levels from the first to the fourth quartile, with a slope of −0.02 ( p = 0.467).

A negative trend between the appendicular skeletal muscle mass parameter (ASSM) and the expression of PTGER4 has been noted (r = −0.224, p = 0.484).

Restricted cubic spline analysis revealed a positive linear relationship for the risk of limb ischemia (linear, P = 0.006; area under the receiver operating characteristic curve of 0.75 [95% CI, 0.656–0.848]), a U-shaped trend for bleeding events (nonlinear, P = 0.214), and a negative trend for thrombotic events (linear, P = 0.552).

Across forests, the SL CWM increases strongly with climate PC1 (R 2 = 0.32, t = 3.94, df = 26, p = 0.001), corresponding to a negative trend with moister, warmer climates, whereas grasslands do not show a significant association (R 2 = 0.009, t = −0.58, df = 27, p = 0.56).

The GEJC in females showed a negative trend (15.26 to 12.35, a 19% decrease over 30 years), with a − 0.08 ([95% CI: − 0.39 to 0.24], P = 0.596) per 1,000,000 person-years average annual decline (Table 1 and Supplementary Table 2 ).

In order to exclude the possibility that the NLR trend was due to a concurrent bacterial or fungal superinfection, we compared the rates of superinfections among patients who had a positive trend with those who had a negative trend and observed that the presence of a superinfection was not associated with a higher NLR trend at admission (χ 2 (1, N = 469) = 0.45, p = 0.6) ( Fig. 4 ).