Previous studies found a borderline significant influence of L-dopa on the total gut microbiome or discussed the treatment with L-dopa as a possible influencing factor. 14 , 22 , 32 Furthermore, a recent study showed the important role of microbial metabolism in drug availability and degradation in the gut. 20 However, as far as we know, no study specifically addressed changes in microbial community composition in PD related to L-dopa medication in detail.
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p=0.09
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In addition, our data showed a borderline significant effect of sex on moderate drinking at the 3-month follow-up, suggesting that females were more likely to engage in moderate drinking than males.
Overall, we observed a borderline significant association between NO 2 exposure modeled as an averaged lag effect and ischemic stroke risk.
Differences were significant for total movement pathology (APS) and movement deviations of wrist flexion/extension and shoulder elevation as well as a borderline significant difference for elbow pronation/supination.
Patients who underwent neoadjuvant treatment (either chemotherapy or chemoradiotherapy) exhibited a borderline significant increase in the risk of POPF with DL reconstruction.
Although the estimate for men in Group 2 became borderline significant, the overall pattern and differences remained consistent.
Several results in this study were borderline significant, thus a higher sample number may lead to reach significance.
20 There were significant (or borderline significant) differences between those with and without the presence of CAC, not only in terms of traditional risk factors, including age, sex, family history of CAD, cigarette smoking, alcohol consumption, hypertension, systolic and diastolic BP, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, and Framingham Risk Score, but also in vitamin D deficiency, cocaine use, year of ART initiation, duration of exposure to NRTIs, duration of exposure to PIs, and duration of exposure to ARTs.
For p,p’ -DDE and PCB 153, borderline significant associations were observed, only among those with BMI >30 kg/m 2 ( P lin = 0.087 and = 0.062, respectively).
There was an 8 to 9% reduction in the estimate for the severity but only a 1% reduction for prevalence after adjustment for chondral defects and ROA, and the estimates remained significant or borderline significant.
Only the low-exposure category to ARHC had a borderline significant association.
For the daily amount of water intake (< 1,5 l per day), the complete case analysis became borderline significant (OR = 1.26 (95% CI: 1.01;1.57) (Table S 2 ).
The linear estimate for decline was borderline significant in the GEE case, one-third of that shown by the joint model, which represented the largest decline found.
In the COPD group, the mRNA expression of p65 showed borderline significant correlations.
In A2 ( n = 578), HR was borderline significant in model 1 and attenuated in model 2.
Initiating breastfeeding within the first month shows a borderline significant association with CMA, as 58.6% of cases did not start breastfeeding in the first month compared to 35.9% of controls.
Additionally, two modules were borderline significant and enriched for genes related to the mitochondrial envelope membrane.
Results Stroke was significantly associated with PM 2.5 , while associations with NO 2 and BC were borderline significant.
Among the secondary variables, with increasing GI we found higher levels of total cholesterol (ratio 1.05 (95% CI: 1.01, 1.09)) and leptin (ratio 1.21 (95% CI: 1.05, 1.40)) and in addition a borderline significant association with higher levels of insulin (ratio 1.08 (95% CI: 0.99, 1.19)).
Additionally, borderline significant differences were discovered between the high and low SUA levels with respect to the risk of disease failure and distant failure.
Additionally, PHH3 showed significant association with PFS after treatment with somatostatin analogues (HR 1.12 [1.03–1.21]), and borderline significant association with PFS after treatment with peptide receptor radionuclide therapy (HR 1.11 [1.00–1.24]).
All implants showed bleeding on probing at some site at baseline (a peri-implantitis diagnostic criterion); the greatest reduction in bleeding was observed in the test group at 45 and 90 days, and the difference with control group 2 was borderline significant at 90 days.
Conversely, the intronic polymorphism rs1467568 A > G has been associated with a reduced cIMT (Kedenko et al., 2014 ), but only in the male sex, and with a borderline significant reduction for the risk of CAD (Nasiri et al., 2018 ).
A randomized, double-blind trial as well as a meta-analysis of those trials for resectable gastric cancers showed that PSK provided borderline significant benefits in improving the disease-free survival (DFS) and OS [ 9 , 10 ].
A borderline significant association was found also for ALIF (p = 0,013), XLIF (p = 0.029), decompression only (p = 0.021) and association between an anterior and posterior approach (PSF + ALIF or PSF + XLIF) on the same patient (p = 0.035).