This study indicated that in the diabetic population, after adjusting for confounding factors, the risk of CKD increased significantly with increasing quartiles of HOMA-IR (OR: 1.37 (1.07–1.74)), while in the nondiabetic population, after adjusting for confounding factors, there was also an increasing trend of CKD risk with increasing HOMA-IR levels, OR = 1.03, but it did not reach statistical significance (94% CI: 0.89–1.20).
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As said before, in the pineal gland ( Supplementary Table S4J ) phototransduction was also a highly significant pathway ( q- value = 0.006) while in the remaining brain regions it did not reach statistical significance. 3.5 Analysis of differential gene expression in pregnant and non-pregnant goats Samples from the pineal gland were not included in the differential expression analysis, since the removal of an outlier sample decreased the number of replicates from the pregnant group to two, which is insufficient to make a sound statistical analysis.
Compared with nonsurviving infants, surviving ILWH showed a trend for higher C5-specific binding activity measured by ELISA , although this difference did not reach statistical significance ( P = .07) ( Figure 2 A ).
The abundance of IL-6 also showed a trend of increase but did not reach statistical significance (Fig. 8 F).
An overall trend toward an increase in BMI was observed at the long-term follow-up that however did not reach statistical significance due the small sample size, but in the majority of participants BMI changes were stable or improving over time [ 80 , 81 ].
Gene expression analysis showed that baseline TAF1 levels differed between control and patient fibroblast cell lines, and treatment with CORT led to an increasing trend in the expression of the aberrant TAF1-32i transcript but did not reach statistical significance.
In children with 22q11DS, FW span and BW span showed a trend towards a moderate correlation, but this did not reach statistical significance ( r (36) = 0.29, p = 0.083, 95% CI [− 0.04–0.57]).
Furthermore, this cluster (identified as “cDC1c”) showed a trend of positive Hif1a mRNA expression that did not reach statistical significance (Supporting Information: Figure S4B , Table S2 ).
Although differences did not reach statistical significance, a trend towards significance was strongest for the left and right SLF parietal sections.
Conversely, the PD-risk factor T408M (also known as T369M, rs75548401) showed a trend toward a faster rate of cognitive decline that did not reach statistical significance, in keeping with a previous study. 43 The mild GD-causing variant N409S (also known as N370S, rs76763715) has shown inconsistent association with cognitive decline in PD.
ACTT-1 also showed a trend toward reducing mortality, but the difference did not reach statistical significance [3] .
Notably, some clinicopathological factors showed a trend toward differences between molecular subtypes, although they did not reach statistical significance.
During co-treatment of LPS with TMs, Cxcl10 and Il1b levels decreased in sera derived from treated mice compared to those in sera from control mice (treated with LPS+DMSO); the anti-inflammatory cytokine Il10 showed an increasing trend that did not reach statistical significance, whereas Il6 and Tnfα did not show altered levels in mouse sera ( Fig. 7 C).
The number of EPCs showed an increasing trend in the teneligliptin treated group; albeit this did not reach statistical significance.
Serum magnesium concentration showed an increasing trend from the beginning to the end of exercise during MOD and HI sessions that did not reach statistical significance (time effect: p = 0.057).
The absence of coronary lesions showed a trend towards a lower incidence of the primary outcome that did not reach statistical significance.
The acquisition phase was followed by a probe trial which showed a trend for LVR to spend less time in the correct quadrant relative to WT and HVR, but this difference did not reach statistical significance {trending group main effect [ F (2, 31) = 3.237; p = 0.053] with Tukey post-hoc analysis revealing trending group differences: LVR vs.
These levels showed a trend to be also decreased at week 12 in affected versus control mice ( Figure 1 b), although differences did not reach statistical significance.
Although LAP showed a negative trend in relation to the maximum diameter of the EGV blood vessels, this association did not reach statistical significance, possibly due to the partial absence of LAP data.
The fasting glucose level did not reach statistical significance after exercise, despite exhibiting a decreasing trend. 4.
Similarly, vGlut2 and mGluR1 showed a trend toward increased expression in the VDD group compared to the VD‐ hypo and VD‐ hyper groups, although these changes did not reach statistical significance (Figure 5L,M , one‐way ANOVA with Tukey's multiple comparisons post hoc test).
Whilst trypsin and hyaluronidase treatment showed a trend toward increased IFN‐γ‐secreting CAR T cells, the differences did not reach statistical significance, likely due to the inherent variability in IFN‐γ measurements (Figure 4F ).
Stage IV patients were strongly correlated with increased risk of death (HR = 20.68, 95% CI: 2.68–159.23, p = 0.004), whereas Stage II and Stage III patients showed a trend toward increased risk but did not reach statistical significance.
Although NCD status showed a positive trend, it did not reach statistical significance after adjustment.
Widowed/divorced participants showed a trend towards a threefold greater challenge in usual activities (aOR 3.68, 95% CI 0.49 to 27.56) compared with single participants; however, this association did not reach statistical significance due to the wide CI.