The expression of M3R showed a decreasing trend, but it did not reach statistical significance, and the co-localization of ChAT and M3R showed no significant decrease (Fig. 4 A&B).
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At month 1, the PPM 1 group showed a trend toward better visual acuity; however, this difference did not reach statistical significance (p = 0.054 ).
2PWY mice showed a trend toward increase in the latency of tumor formation; however, this did not reach statistical significance ( P = 0.11).
Although differences did not reach statistical significance (probably due to the small number of patients), there was a clear trend for increased cholesterol, LDL, waist circumference, and body mass index values in the patients with suboptimal adherence in our study.
Although these associations did not reach statistical significance, the odds ratios demonstrated an increasing trend.
Among non-diabetic patients, ICU mortality showed a trend toward higher risk with increasing SHR levels, although the difference did not reach statistical significance (P = 0.075; Fig 1A ).
In our current analysis, we also observed that patients with the I1859fs*3 variant showed a trend toward poorer survival, although this did not reach statistical significance.
DN2 B cells showed a trend toward decrease, but the change did not reach statistical significance.
Notably, univariate analysis revealed a positive trend between irAEs and rrAEs and prolonged PFS time, although this did not reach statistical significance.
Diaphragm thickness showed a positive trend but did not reach statistical significance.
Family history of digestive organ malignancy showed a trend toward increased risk but did not reach statistical significance (aHR = 2.90; 95% CI 0.88–9.53; P = 0.08).
MFC-MRD–free survival showed a favorable trend in the maintenance group, although this did not reach statistical significance (2-year MFC-MRD–free survival: 85.5% [95% CI, 74.4–98.3] vs. 68.7% [95% CI, 57.3–82.4], p = 0.051).
Swallowing dysfunction showed a trend toward higher malnutrition risk (RRR = 4.07), though this did not reach statistical significance ( p = 0.070).
The Group × Time interaction showed a trend toward significance but did not reach statistical significance ( p = 0.08), suggesting a greater decline in the gastric bypass group.
Silicone oil evacuation showed a trend toward poorer visual outcomes, although this did not reach statistical significance.
Never understanding medication instructions showed a trend toward association with low adherence but did not reach statistical significance (aOR 1.89, 95% CI 0.91–3.93, p = 0.087).
The univariate analysis revealed significant differences between the groups, whereas the direct comparison analysis showed that the difference between the concordance and upgrading groups did not reach statistical significance ( p = 0.0805) but showed a statistical trend toward higher prostate volume in the upgrading group.
Kaplan–Meier analysis showed a trend towards worse outcomes in patients with subclinical congestion [HR 3.00 (0.88–10.3)], although this did not reach statistical significance, and significantly worse outcomes in patients with clinical congestion [HR of 4.22 (1.34–13.26)], Figure 1 . 4.
Kaplan–Meier survival curves from the first NRP ( Figure 2 A) showed a trend toward poorer survival in patients with IVCs, although the log-rank test did not reach statistical significance ( p = 0.142).
Although the 3D group showed a trend toward shorter WIT, the difference did not reach statistical significance in this series.
Specifically, the odds of macrosomia were markedly elevated among women with early menarche, declined to the lowest level at the reference age, and then showed a positive trend of increasing risk with AAM values greater than 15 years, although this association did not reach statistical significance at the individual later age points.
After propensity score matching, the association was attenuated and did not reach statistical significance (β = 0.26 [95% CI, −0.01–0.52]; p = 0.061), although a numerical trend toward longer procedural duration in the GA group persisted.
In weighted UniFrac analyses, developmental stage and sex did not reach statistical significance (F = 17.33, R2 = 0.257, p = 0.073), but showed a trend toward differentiation.
As an exploratory analysis, we examined the relationship between tumorous CA9 mRNA expression and circulating CA9 levels in 32 HCC specimens and observed a positive trend that did not reach statistical significance when assessed by Spearman’s rank correlation ( online supplemental figure 8 , online supplemental table 15 ).
Similarly, the percentage of peripheral blood blasts showed a trend toward reduction, with a median of 19.5% (7.0–24.0) in TP53 -mutated AML versus 21.0% (16.0–26.0) in non-mutated AML, although the difference did not reach statistical significance ( p = 0.055) (see Supplementary Fig. 1 ).