“did not reach statistical significance”

While patients with higher expression of both BMI1 and CK2α showed a trend towards shorter progression free survival, the data did not reach statistical significance likely due to the limited sample size (Additional file 1 : Figure S2).

However, these recommendations were based mainly on 3 studies: a single randomized trial [ 22 ] which had a high risk of bias by the Cochrane risk assessment tool; a meta-analysis by Berger et al [ 7 ] that showed a trend of reduction in the composite of MI, nonfatal stroke, and cardiovascular death with aspirin that did not reach statistical significance; together with older evidence from the Antithrombotic Trialists’ Collaboration (ATC) meta-analysis [ 4 ].

However, immigrant children showed a trend toward a higher proportion of both TST positivity and active TB, even though the latter did not reach statistical significance likely due to the small sample size.

Thoracic consolidation radiotherapy (TRT) showed a trend toward an OS benefit compared to systemic therapy alone, although this did not reach statistical significance (P = 0.073; Supplementary Figure S2 ).

Concerning the intra-group analysis, although the EBWG showed a trend towards improvement in overall VAS, the difference between T0 and T2 did not reach statistical significance ( p = 0.074).

In Duan et al.’s study, while a decreasing trend in heart rate was observed in the SGB-L group, this change did not reach statistical significance.

Tracheostomy also showed a trend toward being a predictor of readmission but did not reach statistical significance. 3.3.

Although HCO 3 − and PCO 2 did not reach statistical significance, they showed a trend toward abnormal values in patients with extended hospitalization.

Regarding TFC, there was a clear trend toward faster functional decline in CAG-CCG LOI patients, although it did not reach statistical significance ( p = 0.146) ( Figure 4 ).

By contrast, in the HLA-DR-strong group, the ICOS-high group showed a trend toward longer cancer-specific survival (CSS), although this trend did not reach statistical significance ( p = 0.060).

Bioinformatic analysis of The Cancer Genome Atlas (TCGA) database revealed that elevated NSUN2 hyper-expression showed a trend toward unfavorable prognosis, 26 although this association did not reach statistical significance ( P = 0.078) ( Fig. 3 C).

In our study, steroid doses showed a trend toward reduced growth following KTx, although this association did not reach statistical significance.

On the multiplicative scale, the interaction terms showed a positive trend but did not reach statistical significance across the models.

The oral semaglutide group showed a trend of greater reduction in HbA1c for patients aged ≥ 65 years at 6 months, although the difference did not reach statistical significance (≥65 years; −0.80 ± 0.15%; <65 years; −1.22 ± 0.26%; P = 0.18; Figure 4a ).

While this parameter did not reach statistical significance in our analysis, the p value of 0.053 indicates a possible trend toward association that may become clearer with a larger sample size.

Body weight showed a trend toward reduction but did not reach statistical significance.

However, in the multivariate analysis, the association between ADAPT and functional outcomes did not reach statistical significance, although a near-significant trend was observed.

Aggressive ROP (A-ROP) (OR = 3.009, p = 0.106) and a history of systemic surgery (OR = 2.293, p = 0.095) showed a trend being associated with increased risk but did not reach statistical significance in this study.

Kp10 treatment showed a trend toward preventing this reduction in female neonates, though the difference did not reach statistical significance ( p = 0.0692).

Overexpression of the WD1–2 and WD3–4 domains significantly suppressed glucagon-stimulated CREB phosphorylation, whereas basal CREB phosphorylation showed a trend toward reduction that did not reach statistical significance ( Figure 8 C–D ).

The comparison of OS by subtypes at diagnosis showed a trend of better OS for WDLPS compared to DDLPS but did not reach statistical significance ( p = 0.205, Figure 3 ).

Trends in Mortality In-hospital mortality showed a decreasing trend over 2009–2024 based on meta-regression analysis; however, the reduction did not reach statistical significance (β = -0.012, p = 0.055).

A positive trend was observed for folic acid intake, although it did not reach statistical significance ( p = 0.061).

Q8, related to patients’ sense of preparedness, showed a trend toward higher VAS scores in Groups I and II, but did not reach statistical significance (Video I: 9.5 [9.1–9.8], Video II: 9.5 [9.0–9.8], Control: 9.3 [8.5–9.7]; p = 0.08).

When we look at the composite outcomes (including all-cause mortality, myocardial infarction, stroke, and ventricular arrhythmia), colchicine demonstrated a favorable trend however the observed effect did not reach statistical significance after PSM.